Publications by authors named "Yunli Liao"
Article Synopsis
- Pyrazinamide is used to treat both drug-susceptible and multidrug-resistant tuberculosis, and this study looks at factors affecting its pharmacokinetics to improve dosing strategies.
- A population pharmacokinetic model was developed using data from 222 patients in China, revealing that total body weight significantly impacts the drug's clearance.
- Recommendations for fixed dosages based on patient weight were established, suggesting doses of 1500 mg for those weighing 40-70 kg, 1750 mg for 70-80 kg, and 2000 mg for 80-90 kg to ensure effective treatment outcomes.
Tuberculosis (TB) is a highly lethal infectious disease that poses a global threat. Timely and accurate biomarker for TB diagnosis and treatment monitoring remains a pressing need. Ions, the crucial trace element for humans, may be potential targets for TB diagnosis and the forecasting of TB development.
View Article and Find Full Text PDFBackground: Tuberculosis (TB) is one of the world's most deadly chronic infectious diseases; early diagnosis contributes to reducing disease transmission among populations. However, discovering novel diagnostic and prognostic biomarkers is still an important topic in the field of TB. Amino acid is the basic unit of protein composition, and its structure and physicochemical characteristics are more stable.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzes the oral microbiome (saliva and tongue dorsum) of 4,478 individuals, revealing significant differences in microbiome composition based on sex.
- It identifies 11 genetic associations linked to the oral microbiome through a sex-stratified metagenome-genome-wide-association study (M-GWAS).
- The research also demonstrates causal relationships between the oral microbiome and serum metabolites, emphasizing the influence of sex hormones on these interactions.
Population Pharmacokinetic Modeling of Bedaquiline among Multidrug-Resistant Pulmonary Tuberculosis Patients from China.
Antimicrob Agents Chemother
October 2022
Article Synopsis
- * A population pharmacokinetic model was created using data from 99 Chinese adult MDR-TB patients, showing that the drug follows a one-compartment model with first-order absorption.
- * The study found that certain genetic factors (specifically the SNP rs319952) and liver enzyme levels (GGT) significantly affect the drug's clearance, which can guide personalized dosing for better treatment outcomes.
Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes.
Genomics Proteomics Bioinformatics
April 2022
Article Synopsis
- The study analyzed metagenomic data from vaginal, fecal, and salivary samples of over 1,100 Chinese women to explore the microbiome's composition, dominated by lactobacilli, and its influencing factors.
- Factors like pregnancy history, delivery method, and breastfeeding were found to be more significant than menstrual cycle in shaping the microbial community in the vagina.
- The research also identified potential health markers related to menstrual irregularities and overall well-being, emphasizing the need for international collaboration to further understand the microbiome's impact on female reproductive health beyond infections or pre-term births.