Purpose: Ultrasound nanobubbles (NBs) can kill tumor cells, mediated by their effects of cavitation and acoustic perforation through ultrasound, while as novel drug carriers, biomaterial-modified NBs release drugs at a target region. In this work, the ultrasound NBs bridged by biotin-streptavidin were prepared simultaneously to be loaded with both programmed death ligand 1 monoclonal antibody (PD-L1 mAb) and doxorubicin (DOX), which are immune checkpoint inhibitors (ICIs) and chemotherapeutic agents, to synergize immunotherapy and chemotherapy combined with sonodynamic therapy (SDT).
Methods: The PD-L1 mAb/DOX NBs, using bridging affinity biotin (BRAB) technology as a bridge, were prepared by thin-film hydration and mechanical oscillation for the targeted delivery of biotinylated PD-L1 mAb and DOX.
IEEE Trans Cybern
December 2023
In this article, inspired by the Halanay inequality, we study stability of sampled-data systems with packet losses by proposing a nonuniform sampling interval approach. First, a sampled-data controller with an exponential gain is put forward to reduce conservatism. We obtain the sufficient condition for linear sampled-data systems to be exponentially stable by extending the famous Halanay inequality to sampled-data systems.
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