Publications by authors named "Yunlan Lao"
Objective: To investigate whether dihydroartemisinin (DHA) attenuates ischaemia-reperfusion injury (IRI)-induced acute kidney injury (AKI) in mice by inhibiting oxidative stress and inflammation and to explore its potential molecular mechanisms.
Materials And Methods: Network pharmacology analysis was used to screen relevant targets, and molecular docking of DHA with core targets was performed. Molecular dynamics simulation of the target with the lowest binding free energy, NQO1-DHA.
Background: Acute kidney injury (AKI), characterized by necroptosis and activation of MAPK pathway, causes sudden declines in renal function. To date, efficacious treatments are lacking. JianPiYiShen Formula (JPYSF) has a protective effect on the kidneys.
View Article and Find Full Text PDFBackground: Chronic kidney disease (CKD) is a serious health threat worldwide. Defective mitophagy has been reported to induce mitochondrial dysfunction, which is closely associated with CKD pathogenesis. Honokiol (HKL) is a bioactive component of Magnolia officinalis that has multiple efficacies.
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- Cisplatin is a potent anti-cancer drug, but its use is limited due to side effects like kidney damage, affecting 20%-30% of patients, necessitating protective strategies.
- San-Huang decoction (SHD), a Chinese herbal remedy, shows promise in treating kidney issues, and this study aims to uncover how SHD protects against cisplatin-induced acute kidney injury (AKI).
- The research identified three key active compounds in SHD (calycosin, rhein, ginsenoside Rh2) and several target proteins involved in inflammation and apoptosis, suggesting that SHD mitigates kidney damage through anti-inflammatory actions and modulation of cell death pathways.
Background: Chronic kidney disease (CKD) is a major public health problem worldwide. Treatment with renin-angiotensin system inhibitors can achieve only partial efficacy on renal function decline and renal fibrosis in CKD patients. Huangqi-Danshen decoction (HDD) is a basic Chinese herbal pair which is commonly used to treat CKD with good efficacy.
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- - Chronic kidney disease (CKD) is a significant global health issue, and while renin-angiotensin system (RAS) blockade is a common treatment, it has limitations.
- - The study examined the combined effects of perindopril erbumine (PE) and Jian-Pi-Yi-Shen formula (JPYSF), a traditional herbal treatment, on CKD in rats, finding that their combination led to improved renal function and reduced kidney damage.
- - This enhanced protection from CKD is linked to increased expression of sirtuin 3 (SIRT3), better mitochondrial function, and reduced oxidative stress, suggesting a more effective treatment strategy using both PE and JPYSF.