Publications by authors named "Yunlan Fang"
Background: Because of the time and expense associated with the procedures and possible distress to the patient, cystoscopy or other imaging techniques are typically not used for bladder cancer detection before symptoms become present. Alternatively, commercial assays for urinary tumor markers exist but are marred by low sensitivity and high cost. There is a need for a simple and sensitive means of tumor detection, such as via the analysis of urine.
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- Lysine-containing polymers are versatile due to their ability to bind biologically relevant molecules, and this report details the synthesis of polyester dendrimers with lysine groups.
- The study investigates their stability over time and different pH levels, their toxicity to various cell lines, and their potential as nano-detoxification agents for organophosphate compounds.
- The dendrimers, designed with 4, 8, and 16 lysine groups, show promise for applications in drug delivery, gene delivery, and removing organic toxins, notably demonstrating effectiveness in capturing the pesticide dichlorvos.
The delivery of genetic material to cells offers the potential to treat many genetic diseases. Cationic polymers, specifically poly(ethylene imine) (PEI), are promising gene delivery vectors due to their inherent ability to condense genetic material and successfully affect its transfection. However, PEI and many other cationic polymers also exhibit high cytotoxicity.
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