Publications by authors named "Yunjung Woo"
Article Synopsis
- Triple-negative breast cancer (TNBC) is linked to poor patient outcomes and often shows increased autophagy, contributing to tumor growth and resistance to chemotherapy.
- This study highlights ANXA2 as a key player in autophagy regulation in TNBC cells—high ANXA2 levels correlate with worse prognosis and enable enhanced autophagic processes through specific signaling pathways.
- ANXA2 knockdown not only boosts sensitivity to the chemotherapy drug doxorubicin but also significantly reduces tumor growth in mouse models, indicating its potential as a therapeutic target in TNBC treatment.*
The epithelial-to-mesenchymal transition (EMT) process allows carcinoma cells to dissociate from the primary tumor thereby facilitating tumor cell invasion and metastasis. Ras-dependent hyperactive signaling is commonly associated with tumorigenesis, invasion, EMT, and metastasis. However, the downstream effectors by which Ras regulates EMT remain ill defined.
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