Roles of Cx43 and AKAP95 in ovarian cancer tissues in G1/S phase.

Objective: The purpose of this study was to investigate the expression of A-kinase anchor protein 95 (AKAP95), cell cycle protein E1 (cyclinE1) and D1 (cyclinD1), and gap junction protein connexin 43 (Cx43) in ovarian cancer tissues, the relationship between four proteins and clinicopathologic parameters, and the correlation between these proteins.

Methods: The expression of proteins in 54 cases of ovarian cancer tissues was detected by immunohistochemical method.

Results: The positive expression rates of AKAP95, cyclinD1 and cyclinE1 in ovarian cancer tissues were 72.