Carbon-metal metal-metal synergistic mechanism of ethylene electro-oxidation electrolysis of water on TMN sites in graphene.

Acetaldehyde (AA) and ethylene oxide (EO) are important fine chemicals, and are also substrates with wide applications for high-value chemical products. Direct electrocatalytic oxidation of ethylene to AA and EO can avoid the untoward effects from harmful byproducts and high energy emissions. The most central intermediate state is the co-adsorption and coupling of ethylene and active oxygen intermediates (*O) at the active site(s), which is restricted by two factors: the stability of the *O intermediate generated during the electrolysis of water on the active site at a certain applied potential and pH range; and the lower kinetic energy barriers of the oxidation process based on the thermo-migration barrier from the *O intermediate to produce AA/EO.

Abdominal massage: A review of clinical and experimental studies from 1990 to 2021.

Objective: To systematically review the current state and holistic application of abdominal massage (AM).

Design: A systematic review of qualitative evidence was conducted. All English articles exploring the topic of AM that had been published until the end of June 2021 were retrieved.

Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer.

Chemotherapy is still one of the principal treatments for gastric cancer, but the clinical application of 5-FU is limited by drug resistance. Here, we demonstrate that ferroptosis triggered by STAT3 inhibition may provide a novel opportunity to explore a new effective therapeutic strategy for gastric cancer and chemotherapy resistance. We find that ferroptosis negative regulation (FNR) signatures are closely correlated with the progression and chemoresistance of gastric cancer.

Tuina combined with diet and exercise for simple obesity: A protocol for systematic review.

Background: The incidence of simple obesity is increasing annually, with the number of obese people in all age groups increasing significantly. Obesity has become an important public health concern. Simple obesity affects not only appearance but also health.

Community intervention study of viscera massage in overweight/obese type 2 diabetes high-risk population.

Background: Prediabetes is an intermediate metabolic state between normoglycemia and diabetes. Without intervention, prediabetes often progresses to diabetes and prediabetes is associated with increased risk of cardiovascular disease, cancer, renal disease, and dementia. Lifestyle modification play a major role in controlling prediabetes.

Efficacy and safety evaluation of acupuncture in the treatment of impaired glucose regulation: A protocol for systematic review and meta-analysis.

Background: Impaired of glucose regulation belongs to the stage of prediabetes, which is a state of glucose metabolism between diabetes and normal blood glucose. The prevalence of prediabetes in people over 20 years old in China is significantly higher than that in diabetic patients. If no measures are taken to prevent the transition from prediabetes to diabetes, the number of diabetic patients in China will further increase.

Degradation Mechanism of Benzo[]pyrene Initiated by the OH Radical and O: An Insight from Density Functional Theory Calculations.

The degradation mechanism of benzo[]pyrene (BaP) initiated by OH and O in aqueous solution is investigated by density functional theory calculations. The main degradation products are BaP-1,6-quinone, BaP-3,6-quinone, BaP-4,6-quinone, and BaP-6,12-quinone. OH and HO are the main intermediate radical species.

β-elemene suppresses Warburg effect in NCI-H1650 non-small-cell lung cancer cells by regulating the miR-301a-3p/AMPKα axis.

β-elemene has been evidenced to suppress the development of numerous cancers including lung cancer. Previous research has found that in A549 cells, β-elemene increased the expression of adenosine monophosphate-activated protein kinase (AMPK) α (AMPKα), which negatively regulates the Warburg effect. Bioinformatics predicted that binding sites exist between AMPKα and miR-301a-3p, an miRNA that has shown oncogenic function in many cancers.

Reduction of NO by H Catalyzed by Keggin-Type Phosphotungstic Acid Supported Single-Atom Catalysts: An Insight from Density Functional Theory Calculations.

In the present paper, the mechanisms of NO reduction by H were systemically examined over various polyoxometalate-supported single-atom catalysts (SACs) M/PTA (M = Fe, Co, Mn, Ru, Rh, Os, Ir, and Pt; PTA = [PWO]) by means of density functional theory calculations. Among these M/PTA SACs, Os/PTA SAC possesses high activity for NO reduction by H with a relatively low rate-determining barrier. The favorable catalytic pathway involves the first and second NO decomposition over the Os/PTA SAC and hydrogenation of the key species after the second NO decomposition.

Activation mechanism of hydrogen peroxide by a divanadium-substituted polyoxometalate [γ-PVWO(μ-OH)]: A computational study.

In the present paper, the reaction mechanism corresponding to activation of hydrogen peroxide (HO) by a divanadium-substituted polyoxometalate (POM) [γ-PVWO(μ-OH)] (I) to form catalytic active species, peroxo complex [γ-PVWO(μ-η,η-O)] (III), was studied by using the density functional theory (DFT) calculations method with B3LYP functional. The results indicate that coordination of HO to I proceeds via a vanadium-center-assisted proton transfer pathway to remove the first water molecule and form a hydroperoxy intermediate [γ-PVWO(μ-OH) (μ-OOH)] (II). And intermediate II occurs through three successive water-assisted proton transfer steps to remove the second water molecule and finally forms catalytic active species.

Seven major genomic deletions of vaccinia virus Tiantan strain are sufficient to decrease pathogenicity.

Attenuated strain TTVAC7, as a multi-gene-deleted vaccinia virus Tiantan strain (VTT), was constructed by knocking out parts of non-essential genes related to virulence, host range and immunomodulation of VTT, and by combining double marker screening with exogenous selectable marker knockout techniques. In this study, shuttle vector plasmids pTC-EGFP, pTA35-EGFP, pTA66-EGFP, pTE-EGFP, pTB-EGFP, pTI-EGFP and pTJ-EGFP were constructed, which contained seven pairs of recombinant arms linked to the early and late strong promoter pE/L, as well as to enhanced green fluorescent protein (EGFP) as an exogenous selectable marker. BHK cells were co-transfected/infected successively with the above plasmids and VTT or gene-deleted VTT, and homologous recombination and fluorescence plaque screening methods were used to knock out the gene fragments (TC: TC7L ∼ TK2L; TA35: TA35L; TA66: TA66R; TE: TE3L ∼ TE4L; TB: TB13R; TI: TI4L; TJ: TJ2R).

Preclinical pharmacology and toxicology study of Ad-hTERT-E1a-Apoptin, a novel dual cancer-specific oncolytic adenovirus.

Clinical studies have demonstrated that conditionally replicating adenovirus is safe. We constructed an oncolytic adenovirus, Ad-hTERT-E1a-Apoptin, using a cancer-specific promoter (human telomerase reverse transcriptase promoter, hTERTp) and a cancer cell-selective apoptosis-inducing gene (Apoptin). Ad-hTERT-E1a-Apoptin was proven effective both in vitro and in vivo in our previous study.