Publications by authors named "Yunjeh Ko"
Hemostatic particles have specific advantages when applied to narrow and complicated bleeding sites with convenient usage compared to other types of hemostatic agents such as fabrics, foams, and pastes. However, powdery hemostatic agents are easy to desorb from the bleeding surface due to blood flow, which causes a serious decrease in hemostasis function. Here, we introduce bioresorbable flake particulates composed of calcium alginate, starch and polyacrylamide/poly(acrylic acid) ionic networks as a wound adhesive hemostatic agent.
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- The study tested a new hemostatic agent, ActiClot (ATC), comparing its effectiveness and safety against the commercial product FLOSEAL using animal models (rat and porcine).
- ATC significantly decreased bleeding time in the rat liver model compared to gauze, showing a 70% reduction, and performed similarly to FLOSEAL in both models without major differences in effectiveness.
- The safety tests indicated ATC is biocompatible and does not cause inflammation, suggesting it could be a viable option for controlling bleeding in surgical and emergency situations.