Effectiveness of using implementation frameworks to facilitate the implementation of a stroke management guideline in the traditional Chinese medicine hospitals in China: protocol for a factorial randomised controlled trial.

Introduction: Traditional Chinese medicine (TCM) is commonly used alongside Western medicine for stroke management in China. However, there is significant variation in TCM practice, and the utilisation of evidence-based clinical practice guidelines is inadequate. This study aims to evaluate the effectiveness of three popular frameworks-Consolidated Framework for Implementation Research (CFIR), Theoretical Domains Framework (TDF) and Normalization Process Theory (NPT)-in improving implementation outcomes for the integrated TCM and Western medicine clinical practice guideline for stroke management.

Optimizing a link-based travel incentive scheme integrating personal carbon trading for low-carbon commuting.

The pressing need to reduce greenhouse gas emissions and optimize traffic demand underlines the importance of effective travel demand management. Previous studies have explored budget-based and aggregated incentive programs, which diminish a heavy financial burden on governments and tend to be limited in contributing to effective behavior change in practice due to budget issues. This study proposes a personal carbon trading travel incentive (PCTTI) mechanism, to encourage private car commuters using low-carbon travel routes.

Maladaptation in cereal crop landraces following a soot-producing climate catastrophe.

Aerosol-producing global catastrophes such as nuclear war, super-volcano eruption, or asteroid strike, although rare, pose a serious threat to human survival. Light-absorbing aerosols would sharply reduce temperature and solar radiation reaching the earth's surface, decreasing crop productivity including for locally adapted traditional crop varieties, i.e.

BioRT-HBV 1.0: A Biogeochemical Reactive Transport Model at the Watershed Scale.

Reactive Transport Models (RTMs) are essential tools for understanding and predicting intertwined ecohydrological and biogeochemical processes on land and in rivers. While traditional RTMs have focused primarily on subsurface processes, recent watershed-scale RTMs have integrated ecohydrological and biogeochemical interactions between surface and subsurface. These emergent, watershed-scale RTMs are often spatially explicit and require extensive data, computational power, and computational expertise.

Identification of 6-Fluorine-Substituted Coumarin Analogues as POLRMT Inhibitors with High Potency and Safety for Treatment of Pancreatic Cancer.

Increasing evidence has demonstrated that oxidative phosphorylation (OXPHOS) is closely associated with the progression of pancreatic cancer (PC). Given its central role in mitochondrial transcription, the human mitochondrial RNA polymerase (POLRMT) is a promising target for developing PC treatments. Herein, structure-activity relationship exploration led to the identification of compound , which was the first reported POLRMT inhibitor possessing single-digit nanomolar potency of inhibiting PC cells proliferation.

Large Polaron Condensation in a Pseudo-Bilayer Quantum Hall Composite.

There is much interest regarding the "coupled ferroelectricity and superconductivity" in the two-dimensional material, bilayer -MoTe; however, the value and the type of electric polarization are unknown. The device structure and the measurement method show that the measured material is the composite of the pseudo-bilayer quantum Hall system, with a thickness of about thirty-six nanometers. The derived dielectric hysteresis loops and the calculated electronic structure reveal that the condensed large polarons are responsible for the reverse ferroelectricity and the coupled superconductivity.

Self-Reporting Microsensors Inspired by Noctiluca Scintillans for Small-Defect Positioning and Electrical-Stress Visualization in Polymers.

Small defects induce concentrated electrical stress in dielectric polymers, leading to premature failure of materials. Existing sensing methods fail to effectively visualize these defects owing to the invisible-energy state of the electric field. Thus, it is necessary to establish a nondestructive method for the real-time detection of small defects in dielectric polymers.

Aerobically Autoxidized Self-Charge Concept Derived from Synergistic Pyrrolic Nitrogen and Catechol Configurations in N, O Co-Doped Carbon Cathode Material.

Aerobically autoxidized self-charging concept has drawn significant attraction due to its promising chemical charge features without external power supply. Particularly, heteroatom-doped carbon materials with abundant oxidizable sites and good conductivity are expected to be ideal cathode materials. However, there is no well-defined aerobically autoxidized self-charging concept based on heteroatom-doped carbon materials, significantly hindering the design of related carbon cathodes.

Application and development of zero-valent iron (ZVI)-based materials for environmental remediation: A scientometric and visualization analysis.

Zero-valent iron (ZVI)-based materials are among the most widely used engineered particles in the field of environmental remediation. To provide a comprehensive overview of the status and trend of the research on them, this study conducted a quantitative and visual analysis of 6296 relevant publications obtained from Web of Science between 1994 and 2022 using CiteSpace software. By using the bibliometric method, this work systematically analyzed the knowledge structure, research hotspots and trends of ZVI-based materials in this field.

Design, Synthesis, and Biological Evaluation of Esculetin-Furoxan-DEAC Ternary Hybrids for Anti-Triple Negative Breast Cancer.

Twelve new hybrid compounds of Esculetin with nitric oxide (NO) donors and/or mitochondrial targeting groups were designed, synthesized, and evaluated for their anti-tumor activity and mechanism and . Notably, the most potent compound exhibited nanomolar antiproliferative activity on triple-negative breast cancer (TNBC) MDA-MB-231 cells (IC = 8 nM) with a strikingly selective inhibitory effect. The mechanism of involves targeting MDA-MB-231 cells' mitochondria, releasing a high NO concentration, and increasing the expression of cyclophilin D (CypD), leading to increased reactive oxygen species (ROS) and triggering cancer cell apoptosis.

Establishment and Validation of a Pathologic Upgrade Prediction Nomogram Model for Gastric Low-Grade Intraepithelial Neoplasia Patients After the Eradication of .

Background: As yet, there is no unified method of treatment for the evaluation and management of gastric low-grade intraepithelial neoplasia (LGIN) worldwide.

Methods: Patients with gastric LGIN who had been treated with eradication were gathered retrospectively. Based on several relevant characteristics described and analyzed by LASSO regression analysis and multivariable logistic regression, a prediction nomogram model was established.

A prognostic nomogram to predict survival in elderly patients with small-cell lung cancer: a large population-based cohort study and external validation.

Background: Age is an independent prognostic factor for small cell lung cancer (SCLC). We aimed to construct a nomogram survival prediction for elderly SCLC patients based on the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: A total of 2851 elderly SCLC patients from the SEER database were selected as a primary cohort, which were randomly divided into a training cohort and an internal validation cohort.

Architecture inspired structure engineering toward carbon nanotube hybrid for microwave absorption promotion.

Constructing sophisticated 3D structure has been shown to be fruitful in developing carbon nanotubes (CNTs) microwave absorbers (MAs). However, issues with the unclear electromagnetic (EM) responding synergy of CNTs toward substrate and the limited dissipation property caused by the large dense CNTs networks throughout the reported models still need to be resolved. Inspired by the creeper-window-room-structured architecture, an analogous conformal nanostructure of amorphous carbon/CNTs (N-AC/CNTs) hybrid is constructed through an autocatalytic planting approach.

Increasing the HIV testing among MSM through HIV test result exchange mechanism: study protocol for a cluster randomized controlled trial.

Background: HIV testing is an essential gateway to HIV prevention and treatment thus controlling the HIV epidemic. More innovative interventions are needed to increase HIV testing among men who have sex with men (MSM) since their testing rate is still low. We proposed an online HIV test results exchange mechanism whereby the one without a certified online HIV report will be asked to test HIV for exchanging HIV report with others.

Establishment and Verification of a Nomogram for Predicting Survival in Patients with Small Intestinal Gastrointestinal Stromal Tumors.

Background: This study aimed to develop and validate nomograms for predicting overall survival (OS) and cancer-specific survival (CSS) in small intestinal gastrointestinal stromal tumors (SI GISTs).

Methods: Patients diagnosed with SI GISTs were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database and further randomly divided into training and validating cohorts. Univariate and multivariate Cox analyses were conducted in the training set to determine independent prognostic factors to build nomograms for predicting 3- and 5-year OS and CSS.

Spatial and temporal variability of root-zone soil moisture acquired from hydrologic modeling and AirMOSS P-band radar.

The accurate estimation of grid-scale fluxes of water, energy, and carbon requires consideration of sub-grid spatial variability in root-zone soil moisture (RZSM). The NASA Airborne Microwave Observatory of Subcanopy and Subsurface (AirMOSS) mission represents the first systematic attempt to repeatedly map high-resolution RZSM fields using airborne remote sensing across a range of biomes. Here we compare 3-arc-sec (~100-m) spatial resolution AirMOSS RZSM retrievals from P-band radar acquisitions over 9 separate North American study sites with analogous RZSM estimates generated by the Flux-Penn State Hydrology Model (Flux-PIHM).