Publications by authors named "Yunhuan Wang"
Article Synopsis
- * This method allows for the production of various benzothiazoles and benzoxazoles in good to excellent yields, even on a larger scale, under mild conditions.
- * The process involves a proposed reaction mechanism where (-CFPhO)P helps in amide formation, while its hydrolysis product aids in the cyclization reaction to achieve the desired compounds.
A metal-free method is developed to perform the synthesis of urea derivatives utilizing CO as the C1 building block at atmospheric pressure and room temperature. In addition to diverse symmetric and dissymmetric ureas, benzimidazolones and quinazolinone can also be easily prepared using this protocol. Most importantly, the gram-scale preparation of fungicide pencycuron and antipsychotic drug pimavanserin proceeded smoothly under the mild conditions.
View Article and Find Full Text PDFObjective: Anti-gamma-aminobutyric-acid-B receptor (GABAbR) encephalitis is a rare form of autoimmune encephalitis. Until now, there are few biomarkers that can indicate the severity and prognosis of patients with anti-GABAbR encephalitis. The objective of this study was to exam the changes of chitinase-3-like protein 1 (YKL-40) in patients with anti-GABAbR encephalitis.
View Article and Find Full Text PDFObjective: Anti-leucine-rich glioma inactivated 1(LGI1) encephalitis is one rare autoimmune encephalitis which is accompanied by inflammatory responses. (Anti-leucine-rich glioma inactivated 1 (anti-LGI1) encephalitis is an autoimmune disease mediated by inflammatory responses.)This study aimed to investigate the Chitinase 3-like 1(CHI3L1) in anti-LGI1encephalitis patients and evaluate its association with modified Rankin Scale (mRS) score in anti-LGI1 encephalitis at admission and 6 months follow-up.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze how gradient decompression techniques impact intraoperative hypotension and patient outcomes in traumatic brain injury cases over a four-year period.
- It evaluated data from 186 patients, examining factors like pupil abnormalities, Glasgow Coma Scale scores, and various decompression methods (mannitol, hyperventilation, and graded craniotomy) while measuring their association with hypotension and prognosis.
- The results revealed that gradient decompression methods had no significant effect on intraoperative hypotension or patient prognosis, highlighting the need for alternative clinical approaches for treating severe traumatic brain injury.