Mitophagy related diagnostic biomarkers for coronary in-stent restenosis identified using machine learning and bioinformatics.

Percutaneous coronary intervention (PCI) combined with stent implantation is currently one of the most effective treatments for coronary artery disease (CAD). However, in-stent restenosis (ISR) significantly compromises its long-term efficacy. Mitophagy plays a crucial role in vascular homeostasis, yet its role in ISR remains unclear.

Realizing Ultrahigh Cycle Life Anode for Sodium-Ion Batteries through Heterostructure Design and Introducing Electro Active Polymer Coating.

BiS has attracted increasing attention in sodium-ion batteries (SIBs) for its high theoretical capacity and low discharge platform. However, the sodium storage performance of BiS is limited by poor electrical conductivity and volume expansion during cycling. Herein, we report a special polypyrrole (PPy)-coated MoS/BiS (MBS@PPy) heterostructure composite obtained by hydrothermal reaction as an anode material for SIB.

Pre-oxidized and composite strategy greatly boosts performance of polyacrylonitrile/LLZO nanofibers for lithium-metal batteries.

The active cyano-group in polyacrylonitrile has severe passivation of lithium anode under larger current density, which restricts the wide application of polyacrylonitrile(PAN) in lithium metal batteries. Herein, in order to address the excessive passivation of lithium metal by PAN, inspired by the pre-oxidation of carbon fibers, PAN was pre-oxidized at 230 °C, which transformed part of the cyano group into a more chemically stable cyclized structure. The electrochemical and mechanical properties of the composite solid electrolyte were effectively improved by introducing the fast ionic conductor LiLaZrAlO into PAN by electrospinning.

An initiator-free and solvent-free in-situ self-catalyzed crosslinked polymer electrolyte for all-solid-state lithium-metal batteries.

Linear polymer (e.g. polyethylene oxide, PEO) based electrolytes have been widely studied due to their flexibility and relatively good contact against electrodes.

A high performance composite separator with robust environmental stability for dendrite-free lithium metal batteries.

The garnet ceramic LiLaZrTaO (LLZTO) modified separators have been proposed to overcome the poor thermal stability and wettability of commercial polyolefin separators. However, the side reaction of LLZTO in the air leads to deterioration of environmental stability of composite separators (PP-LLZTO), which will limit the electrochemical performance of batteries. Herein, the LLZTO with the polydopamine (PDA) coating (LLZTO@PDA) was prepared by solution oxidation, and then applied it to a commercial polyolefin separator to achieve a composite separator (PP-LLZTO@PDA).

Application and Research Progress of Covalent Organic Frameworks for Solid-State Electrolytes in Lithium Metal Batteries.

Covalent organic frameworks (COFs) are a class of crystalline porous organic polymers with periodic networks that are constructed from small molecular units via covalent bonds, which have low densities, high porosity, large specific surface area, and ease of functionalization. The one-dimension nanochannels in COFs offer an effective means of transporting lithium ions while maintaining a stable structure over a wide range of temperatures. As a new category of ionic conductors, COFs exhibit unparalleled application potential in solid-state electrolytes.

Novel In Situ Growth of ZIF-8 in Porous Epoxy Matrix for Mechanically Robust Composite Electrolyte of High-Performance, Long-Life Lithium Metal Batteries.

Polymer electrolytes (PEs) with high flexibility, low cost, and excellent interface compatibility have been considered as an ideal substitute for traditional liquid electrolytes for high safety lithium metal batteries (LMBs). Nevertheless, the mechanical strength of PEs is generally poor to prevent the growth of lithium dendrites during the charge/discharge process, which seriously restricts their wide practical applications. Herein, a mechanical robust ZIF-8/epoxy composite electrolyte with unique pore structure was prepared, which effectively inhibited the growth of lithium dendrites.

Effectiveness of 2 Pretreatment Methods in Antifogging of Goggles in a COVID-19 Isolation Ward: A Randomized Controlled Trial.

Introduction: This study aimed to compare the effectiveness of the pretreatment of goggles with iodophor solution and antibacterial hand sanitizer to reduce the fogging of goggles.

Methods: A total of 90 health care workers were divided into a control group (n = 30), an iodophor solution group (n = 30), and an antibacterial hand sanitizer group (n = 30). This study evaluated the degree of fogging of goggles and the light transmission, comfort, eye irritation, and the impact of goggles on the medical work of staff.

Gualou Xiebai Decoction ameliorates increased Caco-2 monolayer permeability induced by bile acids via tight junction regulation, oxidative stress suppression and apoptosis reduction.

Gualou Xiebai Decoction (GXD), a classic prescription, is widely used to dealing with inflammatory diseases in China for thousands of years. Abnormal metabolic state of bile acids (BAs) is confirmed to cause intestinal epithelial barrier dysfunction. In preliminary work, we observed that GXD could decrease intestinal permeability in hyperlipidemia mice.

Ketogenic diet attenuates aging-associated myocardial remodeling and dysfunction in mice.

Cardiac aging is manifested as unfavorable geometric and functional alterations in heart. The current work was to test whether a ketogenic diet (KD) impacted aging-associated myocardial remodeling and dysfunction in mice and investigate the underlying mechanism. The young and aged male mice were fed with KD or standard chow for four months.

Effect of resin composition on performance of polymer-infiltrated feldspar-network composites for dental restoration.

This study intends to obtain a kind of polymer-infiltrated ceramic-network (PICN) composite with improved performance for dental restoration. Porous ceramic network was prepared via compressing feldspar powders, followed by resin infiltration using Bis-GMA/TEGDMA or UDMA/TEGDMA mixtures to obtain PICN composites after thermocuring. The sintering parameters (temperature, duration) for the formation of feldspathic network with proper porosity were investigated.

An Ultra-microporous Carbon Material Boosting Integrated Capacitance for Cellulose-Based Supercapacitors.

A breakthrough in advancing power density and stability of carbon-based supercapacitors is trapped by inefficient pore structures of electrode materials. Herein, an ultra-microporous carbon with ultrahigh integrated capacitance fabricated via one-step carbonization/activation of dense bacterial cellulose (BC) precursor followed by nitrogen/sulfur dual doping is reported. The microporous carbon possesses highly concentrated micropores (~ 2 nm) and a considerable amount of sub-micropores (< 1 nm).

Superresilient Hard Carbon Nanofabrics for Sodium-Ion Batteries.

Developing supermechanically resilient hard carbon materials that can quickly accommodate sodium ions is highly demanded in fabricating durable anodes for wearable sodium-ion batteries. Here, an interconnected spiral nanofibrous hard carbon fabric with both remarkable resiliency (e.g.

Composite resin reinforced with fluorescent europium-doped hydroxyapatite nanowires for in-situ characterization.

Objective: The object is to find an easy but efficient way to illustrate the in-situ dispersion of nano-scaled one-dimensional fillers in composite resins, and to correlate their dispersion status with the properties of composite resins.

Methods: Fluorescent europium-doped hydroxyapatite nanowires (HANW:Eu) were synthesized via the hydrothermal method. The HANW:Eu was mixed into Bis-GMA/TEGDMA (60/40, w/w) at different contents (1-5wt.

Exogenous IL-19 attenuates acute ischaemic injury and improves survival in male mice with myocardial infarction.

Background And Purpose: Myocardial infarction (MI) is one of the leading causes of death in China and often results in the development of heart failure. In this work, we tested the therapeutic role of Interleukin-19 (IL-19) in mice with MI and investigated the underlying molecular mechanism.

Experimental Approach: Mice were subjected to MI by ligation of left anterior descending coronary artery (LAD) and treated with IL-19 (10ng g ; i.

Self-Reconstructed Formation of a One-Dimensional Hierarchical Porous Nanostructure Assembled by Ultrathin TiO Nanobelts for Fast and Stable Lithium Storage.

Owing to their unique structural advantages, TiO hierarchical nanostructures assembled by low-dimensional (LD) building blocks have been extensively used in the energy-storage/-conversion field. However, it is still a big challenge to produce such advanced structures by current synthetic techniques because of the harsh conditions needed to generate primary LD subunits. Herein, a novel one-dimensional (1D) TiO hierarchical porous fibrous nanostructure constructed by TiO nanobelts is synthesized by combining a room-temperature aqueous solution growth mechanism with the electrospinning technology.

Treatment with D-β-hydroxybutyrate protects heart from ischemia/reperfusion injury in mice.

The present study was designed to examine the protection of D-β-hydroxybutyrate (BHB) against ischemia/reperfusion (I/R) injury in heart and investigate its underlying mechanism. Male adult mice were exposed to 30 min of ischemia and 24 h of reperfusion. Osmotic pumps were implanted subcutaneously 5 min before reperfusion for continuous delivery of the exogenous BHB (1.

Bio-inspired spider-web-like membranes with a hierarchical structure for high performance lithium/sodium ion battery electrodes: the case of 3D freestanding and binder-free bismuth/CNF anodes.

High gravimetric energy density and volumetric energy density energy storage devices are highly desirable due to the rapid development of electric vehicles, and portable and wearable electronic equipment. Electrospinning is a promising technology for preparing freestanding electrodes with high gravimetric and volumetric energy density. However, the energy density of the traditional electrospun electrodes is restricted by the low mass loading of active materials (e.

High-Performance Li-Ion Capacitor Based on an Activated Carbon Cathode and Well-Dispersed Ultrafine TiO Nanoparticles Embedded in Mesoporous Carbon Nanofibers Anode.

A novel Li-ion capacitor based on an activated carbon cathode and a well-dispersed ultrafine TiO nanoparticles embedded in mesoporous carbon nanofibers (TiO@PCNFs) anode was reported. A series of TiO@PCNFs anode materials were prepared via a scalable electrospinning method followed by carbonization and a postetching method. The size of TiO nanoparticles and the mesoporous structure of the TiO@PCNFs were tuned by varying amounts of tetraethyl orthosilicate (TEOS) to increase the energy density and power density of the LIC significantly.

Blockade of receptor for advanced glycation end products protects against systolic overload-induced heart failure after transverse aortic constriction in mice.

Heart failure is the consequence of sustained, abnormal neurohormonal and mechanical stress and remains a leading cause of death worldwide. The aim of this work was to identify whether blockade of receptor for advanced glycation end products (RAGE) protected against systolic overload-induced heart failure and investigate the possible underlying mechanism. It was found that RAGE mRNA and protein expression was up-regulated in cardiac tissues from mice subjected to pressure overload by transverse aortic constriction (TAC).

[A New Feature Extraction Method of Near-Infrared Spectra Based on the Addition of Historical Data].

In traditional qualitative analysis of near-infrared (NIR) spectra, the stability of recognition models is decreased when new varieties of samples are added into the model. In order to improve the robustness of the model, a new feature extraction method based on the addition of historical data was put forward. The NIR training samples will be collected first, after that the historical data of the same species is added to constitute a larger and richer dataset.

Direct Reduction of Graphene Oxide by Ni Foam as a High-Capacitance Supercapacitor Electrode.

Three dimensional reduced graphene oxide (RGO)/Ni foam composites are prepared by a facile approach without using harmful reducing agents. Graphene oxide is reduced by Ni foam directly in its aqueous suspension at pH 2 at room temperature, and the resultant RGO sheets simultaneously assemble around the pillars of the Ni foam. The RGO/Ni foam composite is used as a binder-free supercapacitor electrode and exhibits high electrochemical properties.

Growth of nickel silicate nanoplates on reduced graphene oxide as layered nanocomposites for highly reversible lithium storage.

The combination of active materials with electrically conductive carbon materials and their contact efficiency are crucial for improving the electrochemical performances of active materials. Here, nickel silicate (NiSiOx) nanoplates are planted in situ on the surface of reduced graphene oxide (RGO) nanosheets to form a two dimensional face-to-face nanocomposite of NiSiOx/RGO for lithium storage. The face-to-face structure enhances the contact efficiency of NiSiOx with RGO, and thus leads to a higher reversible capacity and better rate performance of the NiSiOx/RGO nanocomposite than both carbon nanotube (CNT)@NiSiOx nanocables and NiSiOx.