Publications by authors named "Yunhong Wang"

Background: Cardiac hypertrophy and its associated remodeling are among the leading causes of heart failure. Lysine crotonylation is a recently discovered posttranslational modification whose role in cardiac hypertrophy remains largely unknown. NAE1 (NEDD8 [neural precursor cell expressed developmentally downregulated protein 8]-activating enzyme E1 regulatory subunit) is mainly involved in the neddylation modification of protein targets.

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Glioma is the leading cancer of the central nervous system (CNS). The efficacy of glioma treatment is significantly hindered by the presence of the blood-brain barrier (BBB) and blood-brain tumour barrier (BBTB), which prevent most drugs from entering the brain and tumours. Hence, we established a novel drug delivery nanosystem of brain tumour-targeting that could self-assemble the method using an amphiphilic Zein protein isolated from corn.

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The current success of Graph Neural Networks (GNNs) usually relies on loading the entire attributed graph for processing, which may not be satisfied with limited memory resources, especially when the attributed graph is large. This paper pioneers to propose a Binary Graph Convolutional Network (Bi-GCN), which binarizes both the network parameters and input node attributes and exploits binary operations instead of floating-point matrix multiplications for network compression and acceleration. Meanwhile, we also propose a new gradient approximation based back-propagation method to properly train our Bi-GCN.

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Article Synopsis
  • The study aimed to evaluate various treatment strategies for proximal isolated subclavian artery aneurysms (PISAAs) at a specific institution over a six-year period.
  • It involved a retrospective analysis of 15 patients who underwent different types of procedures, including cervical reconstruction, thoracotomy reconstruction, and endovascular treatment, with a focus on success rates and postoperative outcomes.
  • Results showed high success rates for cervical and thoracotomy reconstructions but highlighted longer operation times and greater blood loss in thoracotomy; endovascular treatment had lower reconstruction rates for related arteries but fewer complications post-surgery.
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Patients with multiple myeloma (MM) are likely to achieve poor therapeutic response when organs are involved. We produced anti-B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR)-T cells, which are in a trial for patients with relapsed/refractory MM. One enrolled patient developed severe heart failure, highly suspected as light chain cardiac amyloidosis.

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Ethnopharmacological Relevance: In the Tibetan region of China, Thlaspi arvense L. is utilized for the prevention and treatment of hyperuricemia (HUA). Thlaspi arvense has been shown to lower uric acid levels in HUA rats in preliminary studies.

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Cervical cancer is the most prevalent among women worldwide. Although the incidence and mortality of cervical cancer have been declining thanks to the wide-scale implementation of cytological screening, it remains a major challenge in clinical treatment. High viability is one of the leading causes of the chemotherapeutic resistance in cervical cancers.

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This research aims to combine the pursuit of literacy cultivation with a focused investigation into the evidence of game-based teaching (GBT). To achieve this, the study employs a mixed-methods approach including the interview method, Delphi method, and network hierarchical analysis (ANP) to analysis Expert opinions and construct a comprehensive GBT evaluation index system. The results indicated that a comprehensive GBT evaluation index system is comprised of five primary indicators: teaching objectives, game-based teaching methods, teaching content, game-based teaching processes, and game-based teaching characteristics.

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  • The TMEM protein family is important for various body functions, but its specific effects on heart cell growth and repair are not well understood.
  • Research shows that TMEM11 actually prevents heart cell growth and inhibits heart repair processes.
  • By blocking TMEM11, heart cell proliferation and heart function improved after injury, suggesting that targeting the TMEM11-METTL1-ATF5-INCA1 pathway could be a new way to help heal damaged hearts.
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Ethnopharmacological Relevance: As an effective medicinal plant, Ligusticum chuanxiong (L. chuanxiong) is traditionally used in China to treat various kinds of dysesthesia caused by liver qi stagnation, chest paralysis and heart pain caused by liver blood stagnation, and bruises and injuries caused by blood stasis. Recent research has confirmed the efficacy of L.

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Article Synopsis
  • - The study aimed to investigate how serum sodium levels at the time of hospital admission relate to overall death rates in patients with heart failure (HF).
  • - Conducted at Fuwai Hospital over a ten-year period, the research included 3,649 HF patients, revealing an average sodium level of 137.19 mmol/L, with mortality rates of 38.7% during a median follow-up of about 3 years.
  • - Results indicated that patients with sodium levels lower than 135 mmol/L faced a significantly higher risk of mortality, suggesting that sodium levels are important indicators of patient prognosis in heart failure cases.
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Brain ischemia is an independent risk factor for Alzheimer's disease (AD); however, the mechanisms underlining ischemic stroke and AD remain unclear. The present study aimed to investigate the function of the ε isoform of protein kinase C (PKCε) in brain ischemia-induced dendritic spine dysfunction to elucidate how brain ischemia causes AD. In the present study, primary hippocampus and cortical neurons were cultured while an oxygen-glucose deprivation (OGD) model was used to simulate brain ischemia.

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Objective: Previous reports on the epidemiology, influencing factors, and the prognostic value of the components of PR interval in hospitalized heart failure patients were limited.

Methods: This study retrospectively enrolled 1182 patients hospitalized with heart failure from 2014 to 2017. Multiple linear regression analysis was used to explore the association between the components of PR interval and the baseline parameters.

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Ethnopharmacological Relevance: Meconopsis quintuplinervia Regel (MQR) belongs to the opium poppy tree plant species, and it has heat purging, detoxification, diuretic, anti-inflammatory, and analgesic effects.

Aim Of Study: MQR has liver-protective properties and can alleviate liver heat. Therefore, this study aimed to observe the effect of MQR extract on acute alcoholic liver injury in mice and explore the mechanism of action of ethyl acetate extract of MQR (MQR-E) on alcohol-induced liver injury in combination with the network pharmacology.

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Article Synopsis
  • This study explores a self-emulsifying drug delivery system (SEDDS) to enhance the solubility and bioavailability of artemisinin, a potentially effective therapeutic compound.
  • The optimal mixture of ingredients for the SEDDS was determined using statistical software, resulting in improved drug loading capacity, solubility, and reduced emulsification time.
  • The results indicated that the SEDDS significantly increased artemisinin's solubility by 33.85 times and its bioavailability by at least 1.47 times compared to the crude drug form.
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Human respiratory syncytial virus (hRSV) is a common contagious virus that causes infections of pediatric pneumonia and specifically impacts infants and small children. The hRSV phosphoprotein is a key component of the viral RNA polymerase, which can interact with nucleocapsid and other partners through its C-terminal tail (CTT) to promote the formation of viral transcriptase complex, where the Phe241 is a key anchor residue. Based on the crystal template-modeled complex structure of hRSV nucleocapsid with a peptidic segment derived from the phosphoprotein's CTT, we successfully introduced a rationally designed halogen-bonded system to the complex interface by substituting para (p)-position of the side-chain phenyl moiety of CTT Phe241 residue with a halogen atom X (X = F, Cl, Br or I).

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The mechanism of cardiovascular diseases (CVDs) is complex and threatens human health. Cardiomyocyte death is an important participant in the pathophysiological basis of CVDs. Ferroptosis is a new type of iron-dependent programmed cell death caused by excessive accumulation of iron-dependent lipid peroxides and reactive oxygen species (ROS) and abnormal iron metabolism.

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Oxidative damage induced by ethanol and its metabolites is one of the factors that fuels the development of alcoholic liver disease (ALD). Selenium (Se) is an effective cofactor for glutathione peroxidase (GPx), and has antioxidant effects that improve ALD. In patients with ALD, ethanol-induced oxidative damage inhibits the synthesis of related Se-containing proteins such as: selenoprotein P (Sepp1), albumin (ALB), and GPx in the liver, thus decreasing the overall Se level in patients.

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Article Synopsis
  • The study aimed to enhance the solubility of dihydroartemisinin (DHA) by using a self-emulsifying drug delivery system (SEDDS).
  • Researchers optimized the formulation through solubility tests and design mixture methods, ultimately validating the optimal prescription ratio for the self-emulsifying agent.
  • Results showed that the SEDDS significantly increased DHA solubility by over 20 times compared to the crude form and improved its absorption in living organisms.
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Scutellariae and Coptidis compose a classical drug pair applied in clinical practice to dispel heat, dryness, and dampness, and they are also precipitation compatible drug pairs. With modern technology, Scutellaria-Coptis is mostly prepared by decocting its components separately, while in the traditional method, it is predominantly prepared as a combined decoction. The present study investigated the effects and mechanisms of separate and combined application of Scutellaria-Coptis decoction on ulcerative colitis (UC) in mice induced by the administration of dextran sulfate sodium (DSS).

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Background: Hypertrophic cardiomyopathy with extreme hypertrophy, biventricular obstruction and diffuse myocardial fibrosis complicated by myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) is a rare phenotype. Evidence and guideline recommendations are still lacking for a treatment strategy.

Case Presentation: Emergency coronary angiography was performed in a 38-year-old man with a 2-year history of nonobstructive hypertrophic cardiomyopathy (HCM) presenting with acute myocardial infarction.

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Background: Several studies have investigated the effect of direct oral anticoagulants (DOACs) in Latin American patients with atrial fibrillation (AF), but the results remain controversial. Therefore, we aimed to compare the efficacy and safety of DOACs vs. warfarin in Latin American patients with AF.

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Aims: Mildly dilated cardiomyopathy (MDCM) was characterized as a subset of dilated cardiomyopathy (DCM) with systolic dysfunction and modest ventricular dilatation, of which the prognostic studies were limited. We aimed to compare the prognostic value of the N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) between MDCM and DCM.

Methods And Results: We retrospectively included hospitalized patients diagnosed with DCM and a left ventricular ejection fraction ≤ 50% at Fuwai Hospital from 2006 to 2017.

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Herba Epimedii, as a traditional Chinese herb, is divided into large and small flower taxa, and can invigorate sexuality and strengthen muscles and bones. Herba Epimedii is rich in flavonoids, which largely contribute to its medicinal benefits. In our previous studies, we have found that the flavonoids content was much more in small than large flower taxa.

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Background: The present study intends to optimize the processing technology for the wine-processing of Rhizoma Coptidis, using alkaloids as indicators.

Method: In the present study, the Box-Behnken design method was adopted to optimize the processing technology for Rhizoma Coptidis, using the alkaloid component quantities as the index. 100 g of Rhizoma Coptidis slices and 12.

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Synopsis of recent research by authors named "Yunhong Wang"

  • - Yunhong Wang's recent research spans various fields, including cardiac health, nanotechnology for drug delivery, and cancer treatment, focusing on innovative methods to address complex medical issues like heart failure and glioblastoma.
  • - Findings from Wang's studies highlight the potential of posttranslational modifications, such as crotonylation, in cardiac hypertrophy, and the effectiveness of biomimetic nanocarriers in overcoming drug delivery challenges posed by the blood-brain barrier in glioma therapy.
  • - Additionally, Wang has contributed to understanding the impact of specific proteins and genetic mechanisms on disease processes, including the role of TMEM11 in cardiomyocyte repair and the implications of PKCε inhibition in preventing ischemia-induced neuronal damage.