Deep Neural Networks (DNNs) are vulnerable to adversarial attacks. Existing methods are devoted to developing various robust training strategies or regularizations to update the weights of the neural network. But beyond the weights, the overall structure and information flow in the network are explicitly determined by the neural architecture, which remains unexplored.
View Article and Find Full Text PDFIEEE Trans Image Process
February 2025
The encoder-decoder architecture is a prevailing paradigm for semantic segmentation. It has been discovered that aggregation of multi-stage encoder features plays a significant role in capturing discriminative pixel representation. In this work, we rethink feature reconstruction for scale alignment of multi-stage pyramidal features and treat it as a Query Update (Q-UP) task.
View Article and Find Full Text PDFWhat Is Already Known About This Topic?: Childhood trauma represents a critical risk factor for substance use among young populations globally, presenting a substantial public health challenge.
What Is Added By This Report?: This comprehensive investigation elucidates the distinct associations between specific subtypes of childhood trauma and substance use behaviors within the Chinese youth population. The findings demonstrate significantly elevated risks for smoking, e-cigarette use, and alcohol consumption, particularly among individuals who have experienced severe or multiple forms of childhood trauma.
Applying amendments to contaminated soil has been considered a successful strategy to control lead (Pb) pollution. In this study, four different types of amendment (calcium hydrogen phosphate, CHP; hydroxyapatite, HA; ordinary Portland cement, OPC; lime, LI) at two treatment levels were used to immobilize Pb in three contaminated soils. The effectiveness of Pb immobilization was assessed by coupling a sequential extraction procedure (fraction) with in vivo mouse model (Pb relative bioavailability, Pb RBA) and in vitro gastrointestinal assays (bioaccessibility).
View Article and Find Full Text PDFGastric cancer remains a leading cause of cancer-related mortality worldwide, with advanced stages presenting significant challenges due to metastasis and drug resistance. Traditional Chinese Medicine (TCM) offers a promising complementary approach characterized by holistic treatment principles and minimal side effects. This review comprehensively explores the multifaceted mechanisms by which TCM addresses gastric cancer.
View Article and Find Full Text PDFObjective: The objective was to evaluate the longitudinal patterns of central and general obesity, identify their genetic and behavioral risk determinants, and investigate the association of distinct obesity trajectories beyond middle age with subsequent cognitive decline and the risk of developing dementia in late life.
Methods: Using a nationally representative, longitudinal, community-based cohort, we examined trajectory patterns of obesity over a 14-year span beyond middle age employing latent mixture modeling. We then evaluated their relationship with subsequent cognitive decline through linear mixed models and with the risk of developing dementia using Cox models, adjusting for confounding variables.
To achieve the assembled connection between dovetail profiled steel sheets and the boundary members in dovetail profiled steel concrete composite shear walls (DPSCWs), self-tapping screws were employed. Three DPSCW specimens connected with self-tapping screws were tested under combined axial and cyclic lateral loads to evaluate their hysteretic response, focusing on the influence of the number of self-tapping screws and the axial compression ratio. The self-tapping screw-connected DPSCWs exhibited a mixed failure mode, characterized by shear failure of the profiled steel sheets and compression-bending failure of multiple wall limbs divided by ribs on the web concrete.
View Article and Find Full Text PDFIn this paper, the mathematical model of the aviation pressure servo valve controlled actuator system(APSVCAS) considering nonlinearity is established based on a jet pipe pressure servo valve in this article. And the dynamic characteristics and stability boundary of APSVCAS are analyzed, which provides theoretical guidance for the actual composition and the determination of parameters. Firstly, a jet-tube two-stage pressure servo valve for aviation hydraulic system is designed, and an accurate model of APSVCAS is established considering multiple nonlinear factors.
View Article and Find Full Text PDFBackground: Declining intrinsic capacity (IC) significantly impacts health outcomes in aging populations. While weak handgrip strength (HGS) is associated with IC impairment, the role of HGS asymmetry remains unclear, especially among older Chinese cohorts.
Methods: We included participants aged ≥60 years from the 2015 wave of the China Health and Retirement Longitudinal Study (CHARLS).
Background: Post-COVID-19 condition (PCC) affects millions of people, and is an essential component of the long-term impact of COVID-19 during the post-pandemic era. Yet, consensus on clinical case definition and core components of PCC remains lacking, affecting our ability to inform research and evidence-based management. Our study aims 1) to identify the most specific symptoms for PCC, and identify clinical subtypes; 2) to evaluate both virus- and host-related determinants of PCC, and 3) assess the impact of PCC on physical and mental health.
View Article and Find Full Text PDFMitochondrial DNA B Resour
October 2024
Behav Sci (Basel)
September 2024
Effective prevention strategies for post-COVID complications are crucial for patients, clinicians, and policy makers to mitigate their cumulative burden. This study evaluated the association of modifiable lifestyle factors (smoking, alcohol intake, BMI, physical activity, sedentary time, sleep duration, and dietary habits) with COVID-19 multisystem sequelae, death, and hospitalization in the UK Biobank cohort (n = 68,896). A favorable lifestyle (6-10 healthy factors; 46.
View Article and Find Full Text PDFMotivation: The annotation of cell types from single-cell transcriptomics is essential for understanding the biological identity and functionality of cellular populations. Although manual annotation remains the gold standard, the advent of automatic pipelines has become crucial for scalable, unbiased, and cost-effective annotations. Nonetheless, the effectiveness of these automatic methods, particularly those employing deep learning, significantly depends on the architecture of the classifier and the quality and diversity of the training datasets.
View Article and Find Full Text PDFBackground: Townes-Brocks syndrome (TBS) is a rare genetic disorder characterized by imperforate anus, dysplastic ears, thumb malformations, and other abnormalities. Previous studies have revealed that mutations in the SALL1 gene can disrupt normal development, resulting in the characteristic features of Townes-Brocks syndrome. Spalt-like transcription factors (SALLs) are highly conserved proteins that play important roles in various cellular processes, including embryonic development, cell differentiation, and cell survival.
View Article and Find Full Text PDF, 2n = 2x = 16, as a perennial species, is widely distributed in China, Mongolia, Russia, etc. It is a traditional Chinese herb used to treat tetanus, rubella pruritus, rheumatic arthralgia, and other diseases. Here, we assembled a 2.
View Article and Find Full Text PDFThe rapid global distribution of COVID-19 vaccines, with over a billion doses administered, has been unprecedented. However, in comparison to most identified clinical determinants, the implications of individual genetic factors on antibody responses post-COVID-19 vaccination for breakthrough outcomes remain elusive. Here, we conducted a population-based study including 357,806 vaccinated participants with high-resolution HLA genotyping data, and a subset of 175,000 with antibody serology test results.
View Article and Find Full Text PDFDocosahexaenoic acid (DHA) is an essential component for brain development during fetal and early postnatal life. Hyperbilirubinemia is characterized by abnormally high levels of bilirubin in the bloodstream, frequently leading to jaundice in newborns. In severe instances, this condition can progress to neurological damage or kernicterus, a form of brain damage.
View Article and Find Full Text PDFIEEE/ACM Trans Comput Biol Bioinform
October 2024
Accurate screening of cancer types is crucial for effective cancer detection and precise treatment selection. However, the association between gene expression profiles and tumors is often limited to a small number of biomarker genes. While computational methods using nature-inspired algorithms have shown promise in selecting predictive genes, existing techniques are limited by inefficient search and poor generalization across diverse datasets.
View Article and Find Full Text PDFDespite evidence indicating increased risk of psychiatric issues among COVID-19 survivors, questions persist about long-term mental health outcomes and the protective effect of vaccination. Using UK Biobank data, three cohorts were constructed: SARS-CoV-2 infection (n = 26,101), contemporary control with no evidence of infection (n = 380,337) and historical control predating the pandemic (n = 390,621). Compared with contemporary controls, infected participants had higher subsequent risks of incident mental health at 1 year (hazard ratio (HR): 1.
View Article and Find Full Text PDFUlcerative colitis (UC) is a gastrointestinal disease with an unknown etiology that severely affects patients' quality of life. Acupuncture and moxibustion therapies are effective in the treatment of UC, but existing systematic reviews (SRs) and meta-analyses (MAs) on this subject have variable methodological and outcome quality. Therefore, this study aimed to summarize and evaluate the evidence of existing SRs and MAs to provide more reliable evidence for clinical practice.
View Article and Find Full Text PDFSingle measures of adiposity markers, such as body mass index (BMI) and waist circumference (WC), are associated with adverse mental health outcomes; however, long-term patterns of adiposity and their health effects remain unclear. The current study assessed adiposity trajectories during a 14-year span beyond middle age and their relevance to mental well-being in late life, and the contribution of genetic and lifestyle factors to the trajectories. Based on a nationally representative sample with longitudinal anthropometric measures, adiposity trajectories were identified by latent mixture modeling, and logistic regression model was used to estimate their associations with mental well-being, with adjustment for confounders.
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