Publications by authors named "Yunhao Xu"
As a distinctive class of porphyrin derivatives, corroles offer exceptional potential in phototherapy applications owing to their unique electronic structures. However, developing metal-organic frameworks (MOFs) that incorporate photosensitive corroles as functional ligands for synergistic phototherapy remains a formidable challenge. Herein, for the first time, the unique phosphorus corrole-based MOFs Cor(P)-Hf with (3,18)-connected gea topology are reported, which are constructed by Cs-symmetric dicarboxylate 3-connected linkers, 10-pentafluorophenyl-5,15-di(p-benzoate)phosphorus corrole (Cor(P)), and the peculiar D-symmetric 18-connected Hf-oxo clusters.
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- Triclocarban (TCC) is an antimicrobial agent that accumulates in environmental systems and has been shown to significantly influence anaerobic sulfur transformations, leading to increased toxic hydrogen sulfide (HS) production.
- Experimental results indicated that TCC enhanced the transfer of sulfur from solid to liquid phases, improved sulfate reduction, and degraded sulfur-containing amino acids, resulting in a 24.76-478.12% increase in HS yields from total suspended solids.
- Additionally, TCC altered the microbial community by enriching bacteria that degrade organic substrates and those that reduce sulfate, boosting the presence of genes related to sulfate transport and reduction processes.
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- Chronic migraine is a complex neurological disorder linked to the IGF1/IGF1r signaling pathway, which impacts pain modulation and is associated with various chronic pain conditions.
- A study using a mouse model induced chronic migraine by nitroglycerin, assessing pain sensitivity and the effects of an IGF1 receptor antagonist, ppp, on pain behaviors and specific neuronal markers.
- Results showed elevated IGF1 in a brain region related to pain, and treatment with ppp reduced pain sensitivity and neuronal dysfunction, suggesting the pathway's crucial role in managing chronic migraine.
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- The study explores metabolic dysregulation in stroke and Alzheimer's disease (AD) to uncover shared patterns and potential intervention targets.
- Researchers integrated single-cell RNA sequencing from ischemic stroke (IS), hemorrhagic stroke (HS), and AD models to analyze metabolic flux at a single-cell level, revealing common metabolic changes in endothelial cells.
- Key findings suggest that altered metabolic pathways may decrease important metabolites like pyruvate and fumarate, with potential transcriptional regulators Lef1, Elk3, and Fosl1 identified as targets for future neurodegeneration interventions.
Article Synopsis
Biomarkers identification and detection based on GMR sensor and sub 13 nm magnetic nanoparticles.
Annu Int Conf IEEE Eng Med Biol Soc
March 2010