Transdermal Delivery of Valproate-Choline Ionic Liquid Induces Hair Regrowth.

Alopecia treatment research has been increasingly focused on innovative materials systems and drug delivery methods. Valproic acid (VPA) has been shown to promote hair regrowth by upregulating the Wnt/β-catenin signaling pathway, a key regulator of hair papilla cell proliferation. However, topical administration of VPA typically requires organic solvents or complex transdermal devices to enhance skin penetration.

Dual-Gradient Silk-Based Hydrogel for Spatially Targeted Delivery and Osteochondral Regeneration.

Contemporary clinical interventions for cartilage injuries focus on symptom management through pharmaceuticals and surgical procedures. Recent research has aimed at developing innovative scaffolds with biochemical elements, yet challenges like inadequate targeted delivery and reduced load-bearing capacity hinder their adoption. Inspired by the spatial gradients of biophysical and biochemical cues in native osteochondral tissues, a silk-based hydrogel that facilitates spontaneous dual-gradient formation, including mechanical gradients and growth factor gradients, for tissue regeneration, is presented.

The design and evaluation of the outflow structures of an interventional microaxial blood pump.

Blood pump design efforts are focused on enhancing hydraulic effectiveness and minimizing shear stress. Unlike conventional blood pumps, interventional microaxial blood pumps have a unique outflow structure due to minimally invasive technology. The outflow structure, composed of the diffuser and cage bridges, is crucial in minimizing the pump size to provide adequate hemodynamic support.

A novel model for hemolysis estimation in rotating impeller blood pumps considering red blood cell aging.

For blood pumps with a rotating vane-structure, hemolysis values are estimated using a stress-based power-law model. It has been reported that this method does not consider the red blood cell (RBC) membrane's shear resistance, leading to inaccurate estimation of the hemolysis value. The focus of this study was to propose a novel hemolysis model which can more accurately predict the hemolysis value when designing the axial flow blood pump.

Preparation of lightweight daisy-like magnetic molecularly imprinted polymers via etching synergized template immobilization for enhanced rapid detection of trace 17β-estradiol.

17β-estradiol (E2), as one of the pharmaceutical and personal care product, frequently contaminates environmental water as estrogen pollutant and possesses great risk to human survival as well as the sustainable development of the ecosystem. Herein, to achieve an effective adsorbent system for the selective removal of E2 from the environmental water, FeO nanoparticles are subjected to chemical etching to reduce the overall mass and then employed as carriers to prepare a novel type of lightweight daisy-like magnetic molecularly imprinted polymers (LD-MMIPs) adopting template immobilization strategy. The LD-MMIPs based etched magnetic nanoparticles not only exhibit light mass but also have plentiful imprinted sites in the etched channels, which significantly increases the adsorption capacity for E2.

[Design of the Rolling Type Nasal Feeding Perfusion Apparatus].

At present, the existing problem in nasal feeding perfusion apparatus is laborious and instability. Designing the rolling type perfusion apparatus by using a roller pump, the problem is solved. Compared with the traditional perfusion apparatus, the advantage lies in liquid carrying only need once and simulating human swallowing process.

[Study on Tracheal Intubation's Circular Arc Radius Measuring Method Based on Machine Vision].

It is difficult to measure the circular arc radius for central angle less than 30 degrees. The existing measuring methods are of low efficiency and big error. Through designing the machine vision system and studying the image detecting method for measurement, It is obtained good results by using the new measurement for tracheal intubation's circular arc radius, Realized a rapid and accurate measurement of the circular arc radius, and expanded the application in the field of machine vision.