Publications by authors named "Yunhao Deng"
Advances in Carbon Dot Based Enhancement of Photodynamic Therapy of Tumors.
ACS Appl Bio Mater
December 2024
Article Synopsis
- Photodynamic therapy (PDT) offers high selectivity and less invasiveness for cancer treatment, but faces challenges like limited penetration depth and oxygen deficiency.
- Carbon dots are being explored to enhance PDT due to their superior optical and physicochemical properties.
- The review discusses how carbon dots can improve PDT and outlines various synergistic therapies that combine carbon dots with other treatments for more effective and safer cancer therapies.
Article Synopsis
- Researchers developed a copper-doped carbon nanozyme (CC) that exhibits multiple enzyme-like activities to generate reactive oxygen species (ROS) for cancer treatment, overcoming challenges like low biocompatibility and effectiveness in the tumor environment.
- The nanozyme was combined with a photosensitizer and gelatin to create a ROS amplifier (CCC) that enhances its biocompatibility, reduces hemolysis, and allows for enzyme-responsive degradation.
- CCC effectively induces a “ROS storm” to destroy cancer cells by boosting ROS production through various enzyme-like activities and demonstrating strong anti-tumor effects in both lab and live tests.