Pasteurella multocida activates apoptosis via the FAK-AKT-FOXO1 axis to cause pulmonary integrity loss, bacteremia, and eventually a cytokine storm.

Pasteurella multocida is an important zoonotic respiratory pathogen capable of infecting a diverse range of hosts, including humans, farm animals, and wild animals. However, the precise mechanisms by which P. multocida compromises the pulmonary integrity of mammals and subsequently induces systemic infection remain largely unexplored.

Pasteurella multocida activates Rassf1-Hippo-Yap pathway to induce pulmonary epithelial apoptosis.

Pasteurella multocida is an opportunistic zoonotic pathogen that primarily causes fatal respiratory diseases, such as pneumonia and respiratory syndromes. However, the precise mechanistic understanding of how P. multocida disrupts the epithelial barrier in mammalian lung remains largely unknown.

Transcriptomic Analysis Reveals the Potential Mechanisms for Improving Carotenoid Production in Z11 under Light Stress.

Carotenoids, as a type of tetraterpene compound, have been widely used in food, medical, and health areas owing to their antioxidant, immune enhancement, and disease risk reduction effects. is a promising oleaginous red yeast that can industrially synthesize carotenoids. In this study, the effects of different light exposure times and intervals on carotenoid production by Z11 were first investigated.

Emergence and genomic analysis of a novel sublineage of bovine ephemeral fever virus in Southwest China.

Introduction: Bovine ephemeral fever virus (BEFV), belonging to the genus under the family , is the etiological cause for the bovine ephemeral fever (BEF) in cattle and water buffalo.

Methods: In this study, we report recent BEF outbreaks in Southwest China and sequence the complete genome sequence of one BEFV isolate BEFV/CQ1/2022.

Results And Discussion: Comparative genomic analyses between BEFV/CQ1/2022 and isolates available in GenBank revealed remarkable inter-isolate divergence.

Carotenoids production and genome analysis of a novel carotenoid producing Rhodococcus aetherivorans N1.

Carotenoids are a series of natural pigments with unique structure and physiological functions. In this study, a novel Rhodococcus aetherivorans strain N1 was discovered, which can produce 6.4 mg/g carotenoids including β-carotene, zeaxanthin and isorenieratene from glucose.

RAA Enzyme Is a New Family of Class A Extended-Spectrum β-Lactamase from Riemerella anatipestifer Strain RCAD0122.

Whole-genome sequencing of Riemerella anatipestifer isolate RCAD0122 revealed a chromosomally located β-lactamase gene, , which encoded a novel class A extended-spectrum β-lactamase (ESBL), RAA-1. RAA-1 shared ≤65% amino acid sequence identity with other characterized β-lactamases. The kinetic assay of native purified RAA-1 revealed ESBL-like hydrolysis activity.

Challenges and Future Perspectives of Promising Biotechnologies for Lignocellulosic Biorefinery.

Lignocellulose is a kind of renewable bioresource containing abundant polysaccharides, which can be used for biochemicals and biofuels production. However, the complex structure hinders the final efficiency of lignocellulosic biorefinery. This review comprehensively summarizes the hydrolases and typical microorganisms for lignocellulosic degradation.

Introducing Trifluoromethyl to Strengthen Hydrogen Bond for High Efficiency Organic Solar Cells.

Nowadays, the ternary strategy has become a common way to improve the power conversion efficiency (PCE) of organic solar cells (OSCs). The intermolecular interaction between the third component and donor or acceptor plays a key role in achieving a high performance. However, hydrogen bond as a strong intermolecular interaction is rarely considered in ternary OSCs.