SEMA3G-NRP1 Signaling Functions as an Immune Checkpoint that Enables Tumor Immune Evasion by Impairing T Cell Cytotoxicity.

T cells within the tumor microenvironment frequently exhibit dysfunctional characteristics that compromise their ability to elicit both innate and therapeutic-induced immune responses. Regulators of immune dysfunction represent therapeutic targets to activate anti-tumor immunity. In this study, we identified semaphorin 3G (SEMA3G) as a key regulator of immune responses in cancer.

DTASUnet: a local and global dual transformer with the attention supervision U-network for brain tumor segmentation.

Glioma refers to a highly prevalent type of brain tumor that is strongly associated with a high mortality rate. During the treatment process of the disease, it is particularly important to accurately perform segmentation of the glioma from Magnetic Resonance Imaging (MRI). However, existing methods used for glioma segmentation usually rely solely on either local or global features and perform poorly in terms of capturing and exploiting critical information from tumor volume features.

Perioperative immunotherapy for patients with EGFR mutant non-small cell lung cancer: Unexpected potential benefits.

Given that immunotherapy has resulted in a significant overall survival (OS) benefit in advanced-stage disease, it is of notable interest to determine the effectiveness of these agents in early-stage non-small cell lung cancer (NSCLC). The potential exists for the immunotherapeutic approach in early-stage NSCLC to mirror the paradigm seen in advanced NSCLC, wherein survival enhancements have notably benefited the majority of patients. However, their performance in early-stage epidermal growth factor receptor (EGFR) mutant NSCLC is controversial.

Study on the change of miners' psychological state under different illuminance levels.

The poor lighting environment in the underground coal mine is easy to cause the miners to have psychological irritability, which leads to the occurrence of accidents. In order to reduce the incidence of accidents and ensure the personal safety of miners. In this paper, different illumination levels are used as control variables.

Advancing hydrogen generation: Kinetic insights and process refinement for sorption-enhanced steam gasification of biomass utilizing waste carbide slag.

Sorption enhanced steam gasification of biomass (SESGB) presents a promising approach for producing high-purity H with potential for zero or negative carbon emissions. This study investigated the effects of gasification temperature, CaO to carbon in biomass molar ratio [CaO/C], and steam flow on the SESGB process, employing carbide slag (CS) and its modifications, CSSi2 (mass ratio of CS to SiO is 98:2) and CSCG5 (mass ratio of CS to coal gangue (CG) is 95:5), as CaO-based sorbents. The investigation included non-isothermal and isothermal gasification experiments and kinetic analyses using corn cob (CC) in a macro-weight thermogravimetric setup, alongside a fixed-bed pyrolysis-gasification system to assess operational parameter effects on gas product.

Experimental study on integrated desulfurization and denitrification of low-temperature flue gas by oxidation method.

In this paper, TiO catalysts doped with different Fe contents (Fe-TiO catalysts) were prepared by coprecipitation method and the Fe loading capacity was optimized, and then the integrated pollutant removal experiment was conducted, in which TiO doped with Fe as catalyst and HO as oxidant. The results show that under the condition of constant HO/(SO + NO) molar ratio, low concentration of SO can promote the oxidation and removal efficiency of NO, while high concentration of SO can inhibit the removal of NO. The pollutant removal efficiency is proportional to the amount of catalyst, liquid-gas ratio and pH value of the absorbing solution.

Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors.

LILRB4 is an immunosuppressive receptor, and its targeting drugs are undergoing multiple preclinical and clinical trials. Currently, the absence of a functional LILRB4 ligand in solid tumors not only limits the strategy of early antibody screening but also leads to the lack of companion diagnostic (CDx) criteria, which is critical to the objective response rate in early-stage clinical trials. Here, we show that galectin-8 (Gal-8) is a high-affinity functional ligand of LILRB4, and its ligation induces M-MDSC by activating STAT3 and inhibiting NF-κB.

Coupling effect of reaction conditions on the catalytic activity of Cu-Mn composite oxide catalysts for toluene.

Volatile organic compounds (VOCs) are one of the major components of air pollution. Catalytic combustion is a promising technology for the treatment of VOCs and at its center is the preparation of efficient and cheap catalysts. In this study, by loading copper (Cu) and manganese (Mn) on Santa Barbara Amorphous-15 (SBA-15) molecular sieve, the Cu-Mn/SBA-15 ( = 1, 2; = 1, 2) composite metal oxide catalyst was prepared using the equal volume impregnation method.

Co-pyrolysis of peanut shell with municipal sludge: reaction mechanism, product distribution, and synergy.

Biomass/sludge co-pyrolysis contributes to the high-efficiency resource utilization, harmless treatment, and reduction in volume of sludge. Due to the complexity of co-pyrolysis reaction, it is essential to evaluate the thermodynamic behavior, synergy, and reaction mechanism of this process to make it commercially viable. In this work, the pyrolysis properties, thermodynamic analysis and product distribution of municipal sludge (MS), peanut shell (PS), and their blends with various sludge mass ratios (SMRs) were investigated by a thermogravimetric analyzer and a fixed bed reactor.

High-performance sorbents from ionic liquid activated walnut shell carbon: an investigation of adsorption and regeneration.

In this paper, walnut shells were selected to make activated charcoal using ionic activators. Based on the physical/chemical activation process and the properties of activated carbon products, the Fourier Transform Infrared reflection and Brunauer-Emmett-Teller analysis methods were adopted to comparatively analyse activation principles and pore-structure parameters. Also ciprofloxacin adsorption was compared among various activated carbon.

G-MDSC-derived exosomes mediate the differentiation of M-MDSC into M2 macrophages promoting colitis-to-cancer transition.

Backgrounds: In inflammatory bowel disease microenvironment, transdifferentiation of myeloid-derived suppressor cells (MDSCs) and M2 macrophage accumulation are crucial for the transition of colitis-to-cancer. New insights into the cross-talk and the underling mechanism between MDSCs and M2 macrophage during colitis-to-cancer transition are opening new avenues for colitis-associated cancer (CAC) prevention and treatment.

Methods: The role and underlying mechanism that granulocytic MDSCs (G-MDSCs) or exosomes (Exo) regulates the differentiation of monocytic MDSCs (M-MDSCs) into M2 macrophages were investigated using immunofluorescence, FACS, IB analysis, etc employing siRNA and antibodies.

Optimum fractionation of radiation to combine PD-1 blockade.

The optimum fractionation of radiation to combine with immune checkpoint blockade is controversial. This study aimed to investigate the fractionated radiation to maximize immunity during combination therapy. To evaluate the abscopal effect, C57BL/6 hPD-1 knock-in mice bearing two syngeneic contralateral MC38 murine colon cancer tumors were treated with four distinct regimens of radiotherapy.

Research on the optimum carbonization process of walnut shell based on dynamic analysis.

Walnut shell is characterized by high yield, high fixed carbon content, and low ash content. In this paper, the thermodynamic parameters for walnut shell during the carbonization process is investigated, and its carbonization and mechanism are discussed. Then, the optimal carbonization process of walnut shell is proposed.

Studies of the Impact of Rotational Errors on Translation Shifts and Dose Distribution in Image-Guided Radiotherapy.

To compare the 6-dimensional errors of different immobilization devices and body regions based on 3-dimensional cone beam computed tomography for image-guided radiotherapy and to further quantitatively evaluate the impact of rotational corrections on translational shifts and dose distribution based on anthropomorphic phantoms. Two hundred ninety patients with cone beam computed tomographies from 3835 fractions were retrospectively analyzed for brain, head & neck, chest, abdomen, pelvis, and breast cases. A phantom experiment was conducted to investigate the impact of rotational errors on translational shifts using cone beam computed tomography and the registration system.

Construction of SNP fingerprint and population genetic analysis of honeysuckle germplasm resources in China.

Introduction: The flower buds of Thunb. are widely used in Chinese medicine for their anti-inflammatory properties, and they have played an important role in the fight against SARS COVID-19 and other major epidemics. However, due to the lack of scientific and accurate variety identification methods and national unified standards, scattered and non-standardized management in flower bud production has led to mixed varieties that have caused significant difficulties in the cataloging and preservation of germplasm resources and the identification, promotion, and application of new varieties.

LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma.

Radioresistance and immunosuppression remain the major obstacles in the anti-cancer treatments. This work studies the functions of sialic acid binding Ig like lectin 9 (SIGLEC9) and its related molecules in radioresistance and immunosuppression in esophageal squamous cell carcinoma (ESCC). The single-cell analysis showed that SIGLEC9 was mainly expressed on tumor-associated macrophages (TAMs).

Research on Thermal Behaviors and NO Release Properties during Combustion of Sewage Sludge, Sawdust, and Their Blends.

To investigate the thermal behaviors and NO emission properties during combustion of sewage sludge (SS), sawdust (SD), and their blends (SS5SD5, SS3SD7, and SS1SD9 with SD proportions of 50, 70, and 90 wt %, respectively), tests were conducted using thermogravimetry-mass spectrometry (TG-MS), Fourier transform infrared spectroscopy (FTIR), and a tube furnace in this study. Results indicated that hydrogen in the fuel was mainly released during volatile combustion, and carbon conversion proceeded during the whole combustion process. With the SD proportion increasing, samples exhibited better combustion characteristics.

Co-combustion of high alkali coal with municipal sludge: Thermal behaviour, kinetic analysis, and micro characteristic.

Blending sludge rich in protein and aliphatic hydrocarbons into the high alkali coal (HAC) has been demonstrated to reduce the ash melting temperature of the HAC/sludge mixture, thereby increasing the effectiveness and efficiency of liquid slagging. However, whether the incorporation of sludge can affect the combustion stability of the original coal-fired boiler is still debatable. As the combustion stability of the fuel can directly affect the operational safety of the boiler, it is of great practical value for exploring the effect of sludge incorporation on the combustion performance of HAC.

Amino-acid modulated hierarchical In/H-Beta zeolites for selective catalytic reduction of NO with CH in the presence of HO and SO.

Selective catalytic reduction of NO with CH (CH-SCR) has been studied over a series of amino-acid mediated hierarchical beta zeolites with indium exchange. Amino acid mesoporogens greatly affect the NO reduction (DeNO) efficiency of In/H-Beta catalysts. Mesoporous In/H-Beta-P synthesized using proline exhibits the highest NO removal efficiency of 40% in excess oxygen and poisonous SO and HO, 10% higher than our previously optimized In/H-Beta catalyst using commercial beta zeolites with a similar Si/Al ratio.

Correction: IL-17A weakens the antitumor immunity by inhibiting apoptosis of MDSCs in Lewis lung carcinoma bearing mice.

[This corrects the article DOI: 10.18632/oncotarget.13978.

Comparative Analyses between Raw and Preoxidized Pulverized Coals: Combustion Behaviors and Thermokinetic and Microcharacteristics.

Investigating the difference in the combustion performance and microcharacteristics of oxidized and raw pulverized coal (PC) can contribute to effectively prevent and control the spontaneous combustion of deposited coal dust in high-temperature environment and further help guarantee the safe operation of coal-fired boiler. In this study, the combustion performance and thermokinetic and microcharacteristics of three raw coal samples and their preoxidized forms were explored by a thermogravimetric analyzer (TGA) and Fourier transform infrared spectroscopy (FTIR). According to the characteristic temperatures and variations of the mass loss rate during heating, the entire combustion process of PC was divided into four periods.

Research on Combustion Properties and Pollutant Emission Characteristics of Blends of Maltol Byproduct/Pine Sawdust.

In this paper, the combustion and pollutant emission characteristics of maltol byproduct, pine sawdust, and their blends were experimentally studied by thermogravimetry, tube furnace experiment, and scanning electron microscopy. The results show that the combustion process of maltol byproduct, pine sawdust, and their blends can be divided into three stages, in which the volatile release of the maltol byproduct includes two stages. The ignition temperature of the blended fuel is lower than that of sawdust.

Online MR evaluation of inter- and intra-fraction uterus motions and bladder volume changes during cervical cancer external beam radiotherapy.

Purpose/objective(s): The purpose of the study was to assess the uterus motions and bladder volume changes of fractional movements in cervical sites throughout the external beam radiotherapy (EBRT) treatment.

Materials/methods: A prospective online MR imaging tracking study was conducted in EBRT 43 patients with at least 4 scans during each treatment (before: ultrasound scan, MRI scan, CBCT scan, after: MRI scan) were included. In order to improve the treatment repeatability, each patient was instructed to empty the bladder and drink 500 ml water 1 h before CT simulation and each treatment.

THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.

Background: The abnormal upregulation of programmed death-ligand 1 (PD-L1) in cancer cells inhibits T cell-mediated cytotoxicity, but the molecular mechanisms that drive and maintain PD-L1 expression are still incompletely understood.

Methods: Combined analyses of genomes and proteomics were applied to find potential regulators of PD-L1. In vitro experiments were performed to investigate the regulatory mechanism of PD-L1 by thyroid adenoma associated gene (THADA) using human colorectal cancer (CRC) cells.