Publications by authors named "Yung-Yun Chang"

Lung adenocarcinoma (LUAD) is one of the deadliest cancers regarding both mortality rate and number of deaths and warrants greater effort in the development of potential therapeutic targets. The enhancer of rudimentary homolog () has been implicated in the promotion and progression of certain types of cancer. In the present study, was assessed for its expression pattern and survival association with LUAD in public transcriptomic and proteomic databases.

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Lung cancer is one of the deadliest cancers worldwide, including in Taiwan. The poor prognosis of the advanced lung cancer lies in delayed diagnosis and non-druggable targets. It is worth paying more attention to these ongoing issues.

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Article Synopsis
  • Lung adenocarcinoma (LUAD) is a prevalent form of lung cancer with poor survival rates in advanced stages, prompting the need for new treatment targets.
  • The study focused on the role of specific translation initiation factors, particularly EIF4H, which was found to be overexpressed in tumors and linked to worse patient outcomes by affecting cancer cell growth and the immune environment.
  • Findings suggest that regulating EIF4H could provide insights for developing diagnostic biomarkers and therapeutic strategies to improve LUAD treatment.
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Lung cancer is well known for its high mortality worldwide. The treatment for advanced lung cancer needs more attention to improve its survival time. A disintegrin and metallopeptidase with thrombospondin motifs 8 (ADAMTS8) has been linked to several cancer types.

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Lung adenocarcinoma (LUAD) still holds the most dreadful clinical outcomes worldwide. Despite advanced treatment strategies, there are still some unmet needs. Next-generation sequencing of large-scale cancer genomics discovery projects combined with bioinformatics provides the opportunity to take a step forward in meeting clinical conditions.

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Lung cancer remains notorious for its poor prognosis. Despite the advent of tyrosine kinase inhibitors and immune checkpoint inhibitors, the probability of curing the disease in lung cancer patients remains low. Novel mechanisms and treatment strategies are needed to provide hope to patients.

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Lung cancer has been a leading cause of cancer-related death for decades and therapeutic strategies for non-driver mutation lung cancer are still lacking. A novel approach for this type of lung cancer is an emergent requirement. Here we find that loss of LSAMP (Limbic System Associated Membrane Protein), compared to other IgLON family of proteins NTM (Neurotrimin) and OPCML (OPioid-binding Cell adhesion MoLecule), exhibits the strongest prognostic and therapeutic significance in predicting lung adenocarcinoma (LUAD) progression.

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The prognosis of patients with metastatic lung adenocarcinoma (LUAD) is poor. Although novel lung cancer treatments have been developed for metastatic LUAD, not all patients are fit to receive these treatments. The present study aimed to identify the novel regulatory genes in metastatic LUAD.

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For decades, lung cancer has been the leading cause of cancer-related death worldwide. Hypoxia-inducible factors (HIFs) play critical roles in mediating lung cancer development and metastasis. The present study aims to clarify how HIF's over-activation affects lung cancer angiogenesis not only in a normoxic condition, but also a hypoxic niche.

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Lung cancer is one of the leading causes of cancer-related death globally, thus elucidation of its molecular pathology is highly highlighted. Aberrant alterations of the spindle assembly checkpoint (SAC) are implicated in the development of cancer due to abnormal cell division. TTK (, a dual serine/threonine kinase, is considered to act as a cancer promoter by controlling SAC.

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Determining the rehabilitation needs is of great importance in long-term care setting, but the perception of rehabilitation needs may vary extensively between service provider and recipients. The purpose of this study was to assess the differences between the self-perceived and carer-evaluated rehabilitation needs among care home residents. Data of Longitudinal Older Veterans (LOVE) study were sorted for study.

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