Publications by authors named "Yung-Jiun Chen"
The ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulting in the emergence of new variants that are resistant to existing vaccines and therapeutic antibodies, has raised the need for novel strategies to combat the persistent global COVID-19 epidemic. In this study, a monoclonal anti-human angiotensin-converting enzyme 2 (hACE2) antibody, ch2H2, was isolated and humanized to block the viral receptor-binding domain (RBD) binding to hACE2, the major entry receptor of SARS-CoV-2. This antibody targets the RBD-binding site on the N terminus of hACE2 and has a high binding affinity to outcompete the RBD.
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- Cell cryopreservation typically uses highly concentrated cryoprotectants (CPAs) that can be toxic and cause osmotic stress.
- A new method called forced-convective vitrification with liquid oxygen (LOX(bbp)) improves cooling rates and reduces CPA concentration needed for effective vitrification.
- Test results show that this new approach significantly increases cooling rates and lowers the necessary CPA concentration, leading to less toxicity and osmotic stress during the vitrification process.