Ameliorative Effect of Curcumin-Encapsulated Hyaluronic Acid-PLA Nanoparticles on Thioacetamide-Induced Murine Hepatic Fibrosis.

In this study, we developed curcumin-encapsulated hyaluronic acid-polylactide nanoparticles (CEHPNPs) to be used for liver fibrosis amelioration. CD44, the hyaluronic acid (HA) receptor, is upregulated on the surface of cancer cells and on activated hepatic stellate cells (aHSCs) rather than normal cells. CEHPNPs could bind to CD44 and be internalized effectively through endocytosis to release curcumin, a poor water-soluble liver protective agent.

Measuring and analyzing the causes of problematic Internet use.

Since Internet surfing became a daily activity, people have changed their behavior. This research analyzes the causes of problematic Internet use through an online survey, where 1,094 samples were collected. Based on the results of structural equation modeling analysis, the following conclusions are reached: First, novelty, security, and efficiency increase users' online trust.