Publications by authors named "Yung-An Haung"
Innate lymphoid cells (ILCs) are a rare cell population subdivided into ILC1s, ILC2s, and ILC3s, based on transcription factor expression and cytokine production. In models of lung inflammation, the release of alarmins from the epithelium activates ILC2s and promotes the production of Th2-cytokines and the proliferation and migration of ILC2s within the lung. ILC2s are the innate counterpart to CD4 Th2s and, as such, express Gata-3 and produce IL-4, IL-5, and IL-13.
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- ILCs are involved in promoting lung inflammation in asthma through the release of cytokines, and RBPs like RBM3 play an important regulatory role in this process.
- RBM3 is highly expressed in lung ILCs and its levels increase in response to alarmins TSLP and IL-33, which are associated with asthma.
- Studies show that Rbm3 mice experience heightened lung inflammation and ILC activation when exposed to allergens, suggesting that RBM3 has an intrinsic role in regulating ILC responses and cytokine production during allergic reactions.