Publications by authors named "Yunfeng Yu"
Objective: The relationship between gut microbiome and trimethylamine oxide (TMAO) has not been fully elucidated. We aimed to assess the causal effects of different gut microbes on TMAO using Mendelian randomization (MR).
Methods: Gut microbiome and TMAO datasets were acquired from genome-wide association studies and screened for single nucleotide polymorphisms according to the basic assumptions of MR.
Unequal causality between autoimmune thyroiditis and inflammatory bowel disease: a Mendelian randomization study.
Front Endocrinol (Lausanne)
November 2024
Objective: This study aims to analyze the causal relationship between autoimmune thyroiditis (AIT) and inflammatory bowel disease (IBD) using bidirectional Mendelian randomization (MR).
Methods: Single nucleotide polymorphisms were obtained from FinnGen. Exposure-outcome causality was assessed using inverse variance weighted, MR-Egger, and weighted median.
Background: Linarine is a natural chemical component widely found in Buddleja officinalis Maxim., Chrysanthemum indicum L., Mentha canadensis L.
View Article and Find Full Text PDFArticle Synopsis
- This study explores the link between post-traumatic stress disorder (PTSD) and autoimmune thyroid diseases, particularly focusing on autoimmune thyroiditis (AIT) and Graves' disease (GD) using Mendelian randomization (MR).
- Analysis from the data showed no significant causal relationship between PTSD and AIT, but indicated a potential increased risk for developing GD in individuals with PTSD.
- The findings emphasize the need for further research to understand the complex relationship between PTSD and thyroid disorders, particularly given the evidence suggesting genetic links to increased risk for GD.
Effect of post-traumatic stress disorder on type 2 diabetes and the mediated effect of obesity: a Mendelian randomization study.
Front Endocrinol (Lausanne)
September 2024
Objective: Whether the role of post-traumatic stress disorder (PTSD) on type 2 diabetes (T2D) is mediated by obesity or other mediating factors is controversial. This study was designed to assess the impact of PTSD on genetic susceptibility to T2D and mediating factors.
Methods: The datasets for PTSD, T2D, obesity, hypertension, hyperlipidemia, smoking status, and alcohol consumption were obtained from genome-wide association studies.
Auricular pressure as an adjuvant treatment for type 2 diabetes: data mining and meta-analysis.
Front Endocrinol (Lausanne)
September 2024
Article Synopsis
- - This study investigated the effectiveness of auricular pressure therapy combined with conventional treatments for managing type 2 diabetes, analyzing data from various databases until November 2023.
- - The results showed that patients receiving combined treatment had significantly lower levels of fasting blood glucose, postprandial blood glucose, HbA1c, cholesterol, and blood pressure compared to those only on conventional treatment, with no significant increase in adverse events.
- - Key acupoints identified for auricular pressure therapy included AH, TF, AT, CO, and CO, suggesting that this approach could be a valuable addition to diabetes care.
This letter discusses the publication by Feng . Iodine, selenium, and vitamin D are closely associated with thyroid hormone production in humans; however, the efficacy of selenium and vitamin D supplementation for type 2 diabetes mellitus (T2DM) patients with Hashimoto's thyroiditis (HT) remains controversial. In the retrospective study we discuss herein, the authors highlighted significant improvements in thyroid function, thyroid antibodies, blood glucose, and blood lipid in T2DM patients with HT following addition of vitamin D and selenium to their antidiabetic regimens, underscoring the value of these supplements.
View Article and Find Full Text PDFRisk cycling in diabetes and autism spectrum disorder: a bidirectional Mendelian randomization study.
Front Endocrinol (Lausanne)
August 2024
Objective: The relationship between diabetes mellitus (DM) and autism spectrum disorder (ASD) remains controversial. This study aimed to analyze the causal relationship between different types of DM and ASD by bidirectional Mendelian randomization (MR).
Methods: Single nucleotide polymorphisms for type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), gestational diabetes mellitus (GDM), and ASD were obtained from genome-wide association studies.
Background: The impact of type 1 diabetes (T1D) on inflammatory bowel disease (IBD) remains unclear.
Aim: To analyze the causal relationship between T1D and IBD using Mendelian ran-domization (MR).
Methods: Single nucleotide polymorphisms were sourced from FinnGen for T1D, IBD, ulcerative colitis (UC) and Crohn's disease (CD).
Background: The benefits and risks of Xileisan (XLS) in the treatment of ulcerative colitis (UC) remain unclear.
Aim: The present study aimed to evaluate the efficacy and safety of the combination of XLS and mesalazine when treating UC.
Methods: We searched eight databases for clinical trials evaluating the combination of XLS and mesalazine in the treatment of UC, up to January 2024.
The molecular mechanisms driving the onset and metastasis of prostate cancer remain poorly understood. Actin, under the control of actin-binding proteins (ABPs), plays a crucial role in shaping the cellular cytoskeleton, which in turn supports the morphological alterations in normal cells, as well as the invasive spread of tumor cells. Previous research indicates that ABPs of various types serve distinct functions, and any disruptions in their activities could predispose individuals to prostate cancer.
View Article and Find Full Text PDFBackground: The benefits and risks of bifid triple viable preparations in patients with acute ischemic stroke (AIS) are still controversial. This study aimed to assess the efficacy and safety of bifid triple viable preparations in combination with enteral nutrition for the management of AIS.
Methods: Eight public databases including China National Knowledge Infrastructure, China Biology Medicine, VIP, WanFang, EBSCO, PubMed, Cochrane Library, and Web of Science were searched for relevant clinical literature, published through January 2024.
The predominant characteristic of autoimmune gastritis (AIG) is corpus-dominant advanced atrophy, which is mostly observed in the middle to late stages. More reports are needed on the endoscopic features of the early stage. In this report, we present two cases of early-stage AIG in which endoscopic examinations showed no atrophy of the gastric mucosa but displayed a transition of collecting venules from a regular to an irregular arrangement.
View Article and Find Full Text PDFObjective: The effect of mental disorders (MD) on cardiovascular disease (CVD) remains controversial, and this study aims to analyze the causal relationship between eight MD and CVD by Mendelian randomization (MR).
Methods: Single nucleotide polymorphisms of attention-deficit/hyperactivity disorder (ADHD), anorexia nervosa (AN), anxiety disorder (ANX), autism spectrum disorder (ASD), bipolar disorder (BD), depression, obsessive-compulsive disorder (OCD), schizophrenia (SCZ), and CVD were obtained from UK Biobank and FinnGen. Exposure-outcome causality was tested using inverse variance weighted (IVW), MR-Egger, and weighted median.
Objective: The role of different immune cells in autism spectrum disorders (ASD) is still controversial. The purpose of this study was to evaluate the causal effects of different immune cell phenotypes on ASD via Mendelian randomization (MR).
Methods: Datasets of immune cell phenotypes were obtained from the European Bioinformatics Institute, and datasets of ASD were obtained from the IEU Open GWAS project.
Background: The specific benefits of Yangxinshi tablet (YXST) in the treating chronic heart failure (CHF) remain uncertain.
Aim: To systematically evaluate the efficacy and safety of YXST in the treatment of CHF.
Methods: Randomized controlled trials (RCTs) investigating YXST for CHF treatment were retrieved from eight public databases up to November 2023.
Objective: The role of esketamine in pediatric gastrointestinal endoscopy is still unclear. This study aims to evaluate the efficacy and safety of esketamine for pediatric gastrointestinal endoscopy.
Methods: Clinical trials of esketamine for pediatric gastrointestinal endoscopy were searched in eight common databases, up to October 2023.
Article Synopsis
- This study investigates the causal link between hepatitis B virus (HBV) and the risk of type 2 diabetes (T2D) using a method called Mendelian randomization.
- Researchers analyzed genetic data on chronic hepatitis B, liver conditions, and T2D from large databases.
- The findings suggest that chronic hepatitis B may reduce the risk of developing T2D, while liver cirrhosis and fibrosis increase that risk, potentially changing the relationship based on the severity of the liver disease.
The benefits of low-dose esketamine for painless gastrointestinal endoscopy remain unclear. As such, the present study aimed to investigate the efficacy and safety of low-dose esketamine for this procedure. Seven common databases were searched for clinical studies investigating low-dose esketamine for painless gastrointestinal endoscopy.
View Article and Find Full Text PDFA strategic study of acupuncture for diabetic kidney disease based on meta-analysis and data mining.
Front Endocrinol (Lausanne)
March 2024
Objective: The specific benefit and selection of acupoints in acupuncture for diabetic kidney disease (DKD) remains controversial. This study aims to explore the specific benefits and acupoints selection of acupuncture for DKD through meta-analysis and data mining.
Methods: Clinical trials of acupuncture for DKD were searched in eight common databases.
Effect of viral hepatitis on type 2 diabetes: A Mendelian randomization study.
World J Diabetes
February 2024
Background: The effects of viral hepatitis (VH) on type 2 diabetes (T2D) remain controversial.
Aim: To analyze the causal correlation between different types of VH and T2D using Mendelian randomization (MR).
Methods: Single nucleotide polymorphisms of VH, chronic hepatitis B (CHB), chronic hepatitis C (CHC) and T2D were obtained from the BioBank Japan Project, European Bioinformatics Institute, and FinnGen.
Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study.
Front Endocrinol (Lausanne)
March 2024
Objective: The effect of tea on gout and uric acid is still controversial. This study aims to analyze the effect of tea intake on genetic predisposition to gout, idiopathic gout, gout due to impairment of renal function as well as uric acid by Mendelian randomization (MR).
Methods: Forty independent single nucleotide polymorphisms (SNPs) associated with tea intake were selected from UK Biobank.
The aim of this article is to introduce the roles and mechanisms of the JAK2/STAT3 pathway in various cardiovascular diseases, such as myocardial fibrosis, cardiac hypertrophy, atherosclerosis, myocardial infarction, and myocardial ischemiareperfusion. In addition, the effects of phytochemical ingredients and different natural plants, mainly traditional Chinese medicines, on the regulation of different cardiovascular diseases via the JAK2/STAT3 pathway are discussed. Surprisingly, the JAK2 pathway has dual roles in different cardiovascular diseases.
View Article and Find Full Text PDFArticle Synopsis
- - This study aims to explore the causal relationship between vitamin D levels and autoimmune thyroid diseases (AITD) using a method called Mendelian randomization (MR), which analyzes genetic data to draw conclusions.
- - The researchers found that higher levels of serum 25-hydroxyvitamin D were linked to a lower risk of autoimmune thyroiditis (AIT), but not significantly related to autoimmune hyperthyroidism (AIH) or Graves disease (GD).
- - The results indicate that increasing vitamin D levels may help reduce the risk of AIT, suggesting potential benefits of vitamin D supplementation for prevention and treatment of this specific autoimmune condition.
Objective: The efficacy of acupoint catgut embedding (ACE) for the treatment of pre-diabetes remains controversial. Therefore, this study investigated the clinical efficacy and acupoint selection in ACE for the treatment of pre-diabetes.
Methods: Eight common databases were searched for relevant literature on ACE for pre-diabetes.