Anti-nephrin antibody: a potential biomarker of minimal change disease.

Background: Minimal change disease (MCD) is a common pathological type of nephrotic syndrome in children and adults, and the mechanisms remain obscure. The diagnosis of MCD still relies on renal biopsy, lacking effective biological markers. This study explores the diagnostic value of circulating anti-nephrin antibody in MCD patients and evaluates the correlation with disease activity indicators such as proteinuria.

The compensatory enrichment of sphingosine-1-phosphate on HDL in FSGS enhances the protective function of glomerular endothelial cells compared to MCD.

Glomerular endothelial cells (GECs) are pivotal in developing glomerular sclerosis disorders. The advancement of focal segmental glomerulosclerosis (FSGS) is intimately tied to disruptions in lipid metabolism. Sphingosine-1-phosphate (S1P), a molecule transported by high-density lipoproteins (HDL), exhibits protective effects on vascular endothelial cells by upregulating phosphorylated endothelial nitric oxide synthase (p-eNOS) and enhancing nitric oxide (NO) production.

Interacting particle models on the impact of spatially heterogeneous human behavioral factors on dynamics of infectious diseases.

Human behaviors have non-negligible impacts on spread of contagious disease. For instance, large-scale gathering and high mobility of population could lead to accelerated disease transmission, while public behavioral changes in response to pandemics may effectively reduce contacts and suppress the peak of the outbreak. In order to understand how spatial characteristics like population mobility and clustering interplay with epidemic outbreaks, we formulate a stochastic-statistical environment-epidemic dynamic system (SEEDS) via an agent-based biased random walk model on a two-dimensional lattice.

Proteomic Analysis of Idiopathic Nephrotic Syndrome Triggered by Primary Podocytopathies in Adults: Regulatory Mechanisms and Diagnostic Implications.

Idiopathic nephrotic syndrome (NS) is a heterogeneous group of glomerular disorders which includes two major phenotypes: minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). MCD and FSGS are classic types of primary podocytopathies. We aimed to explore the molecular mechanisms in NS triggered by primary podocytopathies and evaluate diagnostic value of the selected proteomic signatures by analyzing blood proteome profiling.

Development of a novel prognostic assessment model for hepatitis B virus-related acute-on-chronic liver failure based on reexamination results.

Acute-on-chronic liver failure (ACLF) is a common clinical emergency and critical illness with rapid progression and poor prognosis. This study aims to establish a more efficient system for the prognostic assessment of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF), which will provide a guiding scheme for subsequent treatment and improve the survival rate of patients. Data on 623 patients with HBV-ACLF were recorded.

Dietary thiamine modulates carbohydrate metabolism, antioxidant status, and alleviates hypoxia stress in oriental river prawn Macrobrachium nipponense (de Haan).

Hypoxia is one of the challenges in prawns aquaculture. However, the role of thiamine, which is a coenzyme in carbohydrate metabolism with antioxidant properties, in reducing hypoxia in prawns aquaculture is currently unknown. We investigated the effects of thiamine on antioxidant status, carbohydrate metabolism and acute hypoxia in oriental river prawn, Macrobrachium nipponense.

Toughening and Hardening Limited Zone of High-Strength Steel through Geometrically Necessary Dislocation When Exposed to Electropulsing.

The enhancement of both low-temperature impact toughness and the hardness of a high strength steel heat-affected zone (HAZ) is investigated by using high-density electropulsing (EP). The athermal and thermal effects of EP on HAZ microstructure and resultant mechanical properties were examined based on physical metallurgy by electron backscattered diffraction and on tests of hardness and impact toughness at -60 °C, respectively. EP parameters were carefully determined to avoid electro-contraction and excessive pollution of the base metal by using numerical simulation.

Eliminating the Brittleness Constituent to Enhance Toughness of the High-Strength Steel Weld Heat-Affected Zone Using Electropulsing.

The evolution of the martensite-austenite (MA) constituent in the heat-affected zone (HAZ) of high-strength steel FH690 welds when subjected to electropulsing (EP) treatment was investigated herein, with the aim of eliminating brittle MA to enhance toughness. The features induced by EPT were correlated with the microstructure and fractography through scanning electron microscopy and electron backscatter diffraction analyses, together constituting an impact property evaluation. The Charpy V-notch impact results showed EPT could improve toughness of the HAZ from 34.

On (Non-)Monotonicity and Phase Diagram of Finitary Random Interlacement.

In this paper, we study the evolution of a Finitary Random Interlacement (FRI) with respect to the expected length of each fiber. In contrast to the previously proved phase transition between sufficiently large and small fiber length, for all d≥3, FRI is NOT stochastically monotone as fiber length increases. At the same time, numerical evidence still strongly supports the existence and uniqueness of a critical fiber length, which is estimated theoretically and numerically to be an inversely proportional function with respect to system intensity.