Publications by authors named "Yunfeng Shi"

A novel and rapid RP-HPLC coupled with nano quantity analyte detector (NQAD) method was developed for determination of ethambutol hydrochloride and (+)2-aminobutanol in drug products. NQAD is an aerosol-based detector that can be used for the direct detection of the substance lacking ultraviolet chromophores. The two highly polar analytes were separated on a C column with mobile phase consists of trifluoroacetic acid solution and methanol and detected with NQAD.

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Since the industrial revolution, the direct impacts of elevated CO concentrations, such as ocean acidification, and indirect impacts, such as extreme drought events, have synergistically influenced coastal ecosystems, including seagrass meadow. Consequently, investigating the individual and combined effects of ocean acidification and extreme drought-induced increased salinity on seagrasses is crucial for enhancing the management and monitoring of these ecosystems. This study used a two-factor crossover indoor simulation experiment to thoroughly examine the effects of seawater acidification at pH 7.

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Adventitious root (AR) formation in plants originates from non-root organs such as leaves and hypocotyls. Auxin signaling is essential for AR formation, but the roles of other phytohormones are less clear. In , at least two distinct mechanisms can produce ARs, either from hypocotyls as part of the general root architecture or from wounded organs during de novo root regeneration (DNRR).

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Article Synopsis
  • Asch. & Schweinf. (1870) is a seagrass species found in tropical and temperate Indo-Pacific coastal waters, forming important ecosystems.
  • The study sequenced and characterized its complete chloroplast genome for the first time, revealing it to be a circular genome of 158,311 bp with various gene types, including 86 protein-coding genes.
  • Phylogenetic analysis indicates that this seagrass clusters with other species in the Cymodoceaceae family, contributing valuable data for future phylogenetic research.
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Radical prostatectomy (RP) is the main treatment for early-stage localized prostate cancer. With the improvement of medical technology, radical prostatectomy is mainly performed under laparoscopy or robot assistance. With the continuous deepening of the Enhanced Recovery After Surgery (ERAS) concept in clinical practice, patients have increasingly high requirements for postoperative recovery.

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Prostate cancer is recognized as one of the most common tumors among men worldwide, yet the molecular mechanisms underlying its progression remain to be fully understood. In this study, we explored the role of interleukin-1 receptor-associated kinase 2 (IRAK2) in the progression of prostate cancer. We discovered that IRAK2 expression is downregulated in prostate cancer tissues and cells.

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Background: Intrauterine devices (IUDs) are among the most popular contraceptive methods globally due to their convenience and cost-effectiveness. However, improper placement can lead to complications such as device migration and uterine perforation, with increased risk observed when IUDs are implanted within four to six weeks postpartum. Typically, patients are asymptomatic or experience mild lower abdominal discomfort or minor abnormal vaginal bleeding following IUD displacement.

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Amomum villosum Lour. (A. villosum) is a valuable herbaceous plant that produces the famous traditional Chinese medicine Amori Fructus.

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Hyaluronic acid (HA)-based tumor microenvironment-responsive nanocontainers are attractive candidates for anticancer drug delivery due to HA's excellent biocompatibility, biodegradability, and CD44-targeting properties. Nevertheless, the consecutive synthesis of stabilized, stealthy, responsive HA-based multicomponent nanomedicines generally requires multi-step preparation and purification procedures, leading to batch-to-batch variation and scale-up difficulties. To develop a facile yet robust strategy for promoted translations, a silica monomer containing a cross-linkable diethoxysilyl unit was prepared to enable in situ crosslinking without any additives.

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Article Synopsis
  • Increasing CO2 levels since the Industrial Revolution have negatively affected coastal ecosystems through ocean acidification and extreme weather events.
  • A study used a simulation experiment to assess how acidification and low salinity affect the seagrass Thalassia hemprichii, finding that acidification can enhance growth and pigment content despite hyposaline stress slowing growth overall.
  • Results indicated that while acidification can mitigate some negative effects of low salinity on T. hemprichii's physiological performance, it does not significantly influence the seagrass's overall growth rate.
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Autophagy is a highly conserved eukaryotic pathway and plays a crucial role in cell survival under stress conditions. Here, we applied a full-length transcriptome approach to study an Arabidopsis autophagy mutant (atg5-1) subjected to nitrogen-starvation, using Oxford Nanopore Technologies. A total of 39,033 transcripts were identified, including 11,356 new transcripts.

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Article Synopsis
  • The study analyzed the diagnostic and prognostic significance of Kruppel-like factor 5 (KLF5) and Runt-related transcription factor 1 (RUNX1) in patients with sepsis-induced acute kidney injury (SI-AKI) by measuring their levels in blood samples from 120 patients divided into SI-AKI and non-AKI groups.
  • Results indicated that both KLF5 and RUNX1 levels were significantly elevated in SI-AKI patients, proving their effectiveness in distinguishing these patients from those without kidney injury.
  • Furthermore, high levels of KLF5 and RUNX1 were linked to poor 28-day survival outcomes in SI-AKI patients, establishing their potential as independent prognostic markers for survival.*
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Background And Objectives: There are limited studies comparing the health utility values of EQ-5D-5L and SF-6Dv2 within the same patient cohorts. The widespread transmission and recurring infections associated with Omicron variants amid the COVID-19 pandemic have resulted in substantial health detriments and increased utilisation of health care resources. This highlights the crucial need to assess the loss in quality-adjusted life years (QALYs).

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Article Synopsis
  • - This study investigates the link between abdominal obesity, measured by a body shape index (ABSI), and the risk of prostate cancer (PCa) in US adults, highlighting the negative impact of visceral fat on PCa development.
  • - Analyzed data from over 11,000 participants in a national health survey, the findings show that higher ABSI correlates with an increased risk of PCa, with odds rising in higher ABSI quartiles.
  • - The results indicate that individuals with elevated ABSI, particularly those who are under/normal weight or obese, have a greater likelihood of developing prostate cancer.
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Precise prediction of phase diagrams in molecular dynamics simulations is challenging due to the simultaneous need for long time and large length scales and accurate interatomic potentials. We show that thermodynamic integration from low-cost force fields to neural network potentials trained using density-functional theory (DFT) enables rapid first-principles prediction of the solid-liquid phase boundary in the model salt NaCl. We use this technique to compare the accuracy of several DFT exchange-correlation functionals for predicting the NaCl phase boundary and find that the inclusion of dispersion interactions is critical to obtain good agreement with experiment.

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Background: More and more investigations reveal that circular RNAs (circRNAs) are involved in cancer progression. CircRNA UBAP2 was closely related to prostate cancer. However, the biological function and specifical mechanism of circUBAP2 are still poorly discovered in prostate cancer (PCa).

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Two doses of the inactivated influenza vaccine (IIV) are generally recommended for children under 9 years old. This study assessed the necessity for a second dose of quadrivalent IIV (IIV4) in children aged 3-8 years. In this randomized, open-label, paralleled-controlled study, 400 children aged 3-8 years who were vaccine-unprimed were randomly assigned at a 1:1 ratio to receive a two-dose (Group 1) or one-dose (Group 2) regimen of IIV4, and 200 who were vaccine-primed received one dose of IIV4 (Group 3).

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Through whole-genome bisulfite sequencing and RNA-seq, we determined the potential impact of autophagy in regulating DNA methylation in , providing a solid foundation for further understanding the molecular mechanism of autophagy and how plants cope with nitrogen deficiency. A total of 335 notable differentially expressed genes (DEGs) were discovered in wild-type (Col-0-N) and an autophagic mutant cultivated under nitrogen starvation (-N). Among these, 142 DEGs were associated with hypomethylated regions (hypo-DMRs) and were upregulated.

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Article Synopsis
  • * The study reveals the metal-insulator transition behavior of VO single-crystal sheets at different scales, showing distinct triangle-like phase patterns that differ from those observed in epitaxial films.
  • * By utilizing freestanding VO sheets and their interaction with monolayer MoS, the research indicates that these materials can tune optical properties and suggests new approaches for designing devices based on their phase transition behaviors.
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Microplastics have been recognized as a novel niche for bacteria. However, studies have characterized the plastisphere microbial community in situ without exploring the microbial changes after transferring to other ecosystems. Here we focus on bacterial succession on typical microplastics (polypropylene and expanded polystyrene) and natural substrates (wood) after transferring from mariculture area to seagrass meadows system.

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Layer transfer techniques have been extensively explored for semiconductor device fabrication as a path to reduce costs and to form heterogeneously integrated devices. These techniques entail isolating epitaxial layers from an expensive donor wafer to form freestanding membranes. However, current layer transfer processes are still low-throughput and too expensive to be commercially suitable.

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Background: Recently, deep convolutional neural networks (CNNs) have been widely adopted for ultrasound sequence tracking and shown to perform satisfactorily. However, existing trackers ignore the rich temporal contexts that exists between consecutive frames, making it difficult for these trackers to perceive information about the motion of the target.

Purpose: In this paper, we propose a sophisticated method to fully utilize temporal contexts for ultrasound sequences tracking with information bottleneck.

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In medical image analysis, collecting multiple annotations from different clinical raters is a typical practice to mitigate possible diagnostic errors. For such multirater labels' learning problems, in addition to majority voting, it is a common practice to use soft labels in the form of full-probability distributions obtained by averaging raters as ground truth to train the model, which benefits from uncertainty contained in soft labels. However, the potential information contained in soft labels is rarely studied, which may be the key to improving the performance of medical image segmentation with multirater annotations.

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In this study, a column experiment was employed to evaluate the nuclide migration behavior in the surrounding rock medium of a near-surface disposal site in China and to investigate the advection-dispersion behavior of tritium (H-3) and plutonium-238 (Pu-238) in highly weathered argillaceous shale. A reasonable numerical model was selected to fit the experimental breakthrough curves (BTCs) and to obtain the relevant migration parameters. The results show the following: (1) the internal structure of the highly weathered argillaceous shale exhibited heterogeneity, and the nuclide migration BTC showed characteristics of a "curve peak moving forward" and a "tail curve trailing"; (2) compared with other models, the stream tube mode could better fit the BTCs and obtain the average dispersion coefficient <>, average distribution coefficient <>, and other parameters; (3) compared to the results of the batch experiment, the distribution coefficient obtained from the column experiment was smaller than that obtained from the batch experiment, which is speculated to be due to the influence of contact time and the contact area between the nuclide and the medium.

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