Photo-crosslinkable methacrylated konjac glucomannan (KGMMA) hydrogels as a promising bioink for 3D bioprinting.

Three-dimensional (3D) bioink with favorable printability, strength, and biocompatibility challenged the 3D bioprinting technology in cartilage tissue engineering. Herein, we innovatively fabricated photo-crosslinkable methacrylated konjac glucomannan (KGMMA) as a novel biomaterial ink for 3D extrusion bioprinting in an attempt to construct precisely patterned tissues. Specifically, konjac glucomannan (KGM) was modified by methacrylic anhydride, which is a kind of photoreactive group, to form KGMMA.

MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis.

Stimulus-responsive therapy permits precise control of therapeutic effect only at lesion of interest, which determines it a promising method for diagnosis and imaging-guided precision therapy. The acid environment and overexpressed matrix metalloproteinases-13 (MMP-13) are typical markers in osteoarthritis (OA), which enables the development of stimulus-responsive drug delivery system with high specificity for OA. We herein demonstrate a nano-micelle based stimuli-responsive theranostic strategy with reporting and drug release controlled by acidic pH and MMP-13 for OA therapy.

Osteogenic Potential of Electrospun Poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/ Poly(ethylene glycol) Nanofiber Membranes.

Nanofibers as niche-biomimetic scaffolds exhibit potential in bone tissue engineering (BTE). Here, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) co-polymer (P34HB)/poly(ethylene glycol) (PEG) nanofiber membranes with a high hydrophilicity and mechanical properties were fabricated by introducing PEG to P34HB via electrospinning. The P34HB/PEG nanofibrous scaffolds were investigated for their potential in the osteogenic differentiation and mineralization of bone marrow mesenchymal stem cells (BMSCs).