Synthesis of 2-(Trifluoromethyl)-[1,2,4]triazolo[5,1-]isoquinoline via Cycloaddition of ,-Cyclic Azomethine Imine with CFCN.

A [3 + 2] cycloaddition of ,-cyclic azomethine imine with in situ-generated CFCN for the construction of 2-(trifluoromethyl)-[1,2,4]triazolo[5,1-]isoquinoline is reported. Remarkably, this process shows a broad substrate scope with excellent functional group tolerance, which is scalable and enables a practical route to a library of 2-(trifluoromethyl)-[1,2,4]triazolo[5,1-]isoquinoline derivatives in moderate to good yields.

The global mismatch between equitable carbon dioxide removal liability and capacity.

Limiting climate change to 1.5°C and achieving net-zero emissions would entail substantial carbon dioxide removal (CDR) from the atmosphere by the mid-century, but how much CDR is needed at country level over time is unclear. The purpose of this paper is to provide a detailed description of when and how much CDR is required at country level in order to achieve 1.

Synthesis of 2-trifluoromethyl benzimidazoles, benzoxazoles, and benzothiazoles condensation of diamines or amino(thio)phenols with CFCN.

A new and efficient method is developed for the synthesis of 2-trifluoromethyl benzimidazoles, benzoxazoles, and benzothiazoles in good to excellent yields by the condensation of diamines or amino(thio)phenols with generated CFCN. Additionally, the synthetic utility of the 2-trifluoromethyl benzimidazole and benzoxazole products is demonstrated gram scale synthesis. The mechanistic study suggests that the reaction proceeds the nucleophilic addition of trifluoroacetonitrile to the amino group of the diamine derivatives to form an imidamide intermediate, followed by intramolecular cyclization.

Core-shell-structured MnSnO@Void@C as a stable anode material for lithium-ion batteries with long cycle life.

Owing to its high theoretical specific capacity, MnSnO has been regarded as a promising electrode material for lithium-ion batteries. However, in suffering from huge volume expansion and pulverization amidst the alloying/dealloying processes, it presents difficulties in applications as an anode material. Herein, a core-shell-structured MnSnO@Void@C anode material was successfully synthesized using a layer-wise assembly and selective etching method.

Synthesis of 2-trifluoromethyl thiazoles [3 + 2] cycloaddition of pyridinium 1,4-zwitterionic thiolates with CFCN.

2,2,2-Trifluoroacetaldehyde -(aryl)oxime was employed for the [3 + 2] cycloaddition of pyridinium 1,4-zwitterionic thiolates for the synthesis of 2-trifluoromethyl 4,5-disubstituted thiazoles. The reaction works well with various substituted pyridinium 1,4-zwitterionic thiolates in moderate to good yields. The synthetic potential of the obtained 2-trifluoromethyl 4,5-disubstituted thiazoles was demonstrated.

Regioselective synthesis of 3-trifluoromethyl 1,2,4-triazoles photocycloaddition of sydnone with CFCN.

A general and regioselective synthesis of 3-trifluoromethyl 1,2,4-triazoles has been achieved through photocycloaddition of sydnone with trifluoroacetonitrile. This method employed trifluoroacetaldehyde -(aryl)oxime as the CFCN precursor and tolerated various functional groups to furnish 3-trifluoromethyl 1,2,4-triazole products in moderate to good yields. Mechanistic experiments revealed an energy transfer from photocatalyst 4-CzIPN to the sydnone substrates.

Regioselective Synthesis of 5-Trifluoromethyl 1,2,4-Triazoles via [3 + 2]-Cycloaddition of Nitrile Imines with CFCN.

We herein describe a general approach to 5-trifluoromethyl 1,2,4-triazoles via the [3 + 2]-cycloaddition of nitrile imines generated in situ from hydrazonyl chloride with CFCN, utilizing 2,2,2-trifluoroacetaldehyde -(aryl)oxime as the precursor of trifluoroacetonitrile. Various functional groups, including alkyl-substituted hydrazonyl chloride, were tolerated during cycloaddition. Furthermore, the gram-scale synthesis and common downstream transformations proved the potential synthetic relevance of this developed methodology.

An Economy-wide Analysis of the Energy and Environmental Impacts of International Trade Policy Adjustments for Chemical Industry in China.

In China, the proportion of energy consumption and carbon emissions embodied in international trade in chemical industry is high. It is important to consider how international trade policy adjustments in chemical industry will affect the economy and environment so as to achieve the goal of carbon intensity. This study investigates the impact of international trade policy adjustments.

2,2,2-Trifluoroacetaldehyde -(Aryl)oxime: A Precursor of Trifluoroacetonitrile.

The preparation of 2,2,2-trifluoroacetaldehyde -(aryl)oxime, a previously inaccessible precursor of trifluoroacetonitrile, via reaction of hydroxylamine and trifluoroacetaldehyde hydrate is reported. This precursor released CFCN in quantitative yield under mildly basic conditions. The precursor was successfully used in the synthesis of trifluoromethylated oxadiazoles.

An aerobic copper-mediated domino process for the synthesis of 3-(trifluoromethylseleno)indoles.

An aerobic copper-mediated domino reaction for the synthesis of 3-(trifluoromethylseleno)indoles by trifluoromethylselenolation of -Ts 2-alkynylaniline with [(bpy)CuSeCF] is reported. This reaction proceeds through sequential oxidation, alkyne coordination, and deprotonation followed by reductive elimination. This mild and robust method is highly functional group tolerant and provides straightforward access to 3-(trifluoromethylseleno)indoles in moderate to good yields.

Synthesis of 2,3-Bis(trifluoromethylseleno) Indoles through an Oxidative Copper-Mediated Domino Reaction.

An oxidative copper-mediated double trifluoromethylselenolation of terminal 2-alkynylanilines using [(bpy)CuSeCF] is reported, providing a moderately efficient and convenient approach to 2,3-bis(trifluoromethylseleno)indoles. Mechanistic studies show that a cascade sequence of oxidation, trifluoromethylselenolation, 5-- cyclization, and elimination is involved in this transformation.