Cylindrical HP-Sb-Templated Five-Layer Polyoxotungstate with Conspicuous Photochromism Triggered by UV or Visible Light.

The heteroanion (HA) component plays an important role in the templating of heteropolyoxometalate (HPA) structures, but polyoxometalates (POMs) formed from two different templates are rarely reported. Herein, we present a five-layer POM [HN(CH)]{[(HPO)WO][HPSbWO]}·16HO () prepared by two kinds of different HA templates. The multilayer heteropolyanion {[(HPO)WO][HPSbWO]} in consists of two trivacant diheteroatom-templated ([HPO] and [SbO]) [HPSbWO] subunits linked by one unusual [(HPO)WO] subcluster via twelve corner-sharing oxygen atoms.

Biomaterial Scaffolds for Periodontal Tissue Engineering.

Advanced periodontitis poses a significant threat to oral health, causing extensive damage and loss of both hard and soft periodontal tissues. While traditional therapies such as scaling and root planing can effectively halt the disease's progression, they often fail to fully restore the original architecture and function of periodontal tissues due to the limited capacity for spontaneous regeneration. To address this challenge, periodontal tissue engineering has emerged as a promising approach.

Variations in the alveolar bone morphology in maxillary molar area: a retrospective CBCT study.

Background: This study quantitatively analyzed the anatomic structure of the alveolar bone in the maxillary molar region at three potential locations for Temporary Anchorage Device (TAD) placement. Additionally, the study compared the variability in this region across different age groups, sagittal skeletal patterns, vertical facial types, and sexes.

Methods: In this retrospective cone-beam computed tomography study, the buccal alveolar bone was analyzed in the posterior molar area of 200 patients, the measurement items include buccal alveolar bone height, alveolar bone thickness, interradicular distance, and maxillary retromolar space.

Age-related alveolar bone maladaptation in adult orthodontics: finding new ways out.

Compared with teenage patients, adult patients generally show a slower rate of tooth movement and more pronounced alveolar bone loss during orthodontic treatment, indicating the maladaptation of alveolar bone homeostasis under orthodontic force. However, this phenomenon is not well-elucidated to date, leading to increased treatment difficulties and unsatisfactory treatment outcomes in adult orthodontics. Aiming to provide a comprehensive knowledge and further inspire insightful understanding towards this issue, this review summarizes the current evidence and underlying mechanisms.

Actomyosin-II protects axons from degeneration induced by mild mechanical stress.

Whether, to what extent, and how the axons in the central nervous system (CNS) can withstand sudden mechanical impacts remain unclear. By using a microfluidic device to apply controlled transverse mechanical stress to axons, we determined the stress levels that most axons can withstand and explored their instant responses at nanoscale resolution. We found mild stress triggers a highly reversible, rapid axon beading response, driven by actomyosin-II-dependent dynamic diameter modulations.

BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly.

The interaction between influenza A virus (IAV) and host proteins is an important process that greatly influences viral replication and pathogenicity. PB2 protein is a subunit of viral ribonucleoprotein (vRNP) complex playing distinct roles in viral transcription and replication. BAG6 (BCL2-associated athanogene 6) as a multifunctional host protein participates in physiological and pathological processes.

Role of GABA receptors in cognition and EEG activity in aged APP and PS1 transgenic mice.

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Recent evidence suggests that gamma-aminobutyric acid B (GABA) receptor-mediated inhibition is a major contributor to AD pathobiology, and GABA receptors have been hypothesized to be a potential target for AD treatment. The aim of this study is to determine how GABA regulation alters cognitive function and brain activity in an AD mouse model.

A wheel-shaped Zr-substituted phosphotungstate [{Zr(CO)} (PO)(PWO)] with tunable proton conduction properties.

A wheel-shaped Zr-substituted phosphotungstate, [N(CH)]KNaH[{Zr(CO)}(PO)(PWO)]·45HO (1), was synthesised from a hexavacant Dawson-type precursor [HPWO] a conventional solution method. Compound 1 features a wheel-shaped polyanion comprising an annular [PWO] cluster supported by a turbine-shaped [{Zr(CO)}(PO)] fragment, with three oxalate groups covalently anchored to W atoms. Compound 1 was systematically characterized by IR, UV, PXRD, TGA and P NMR spectra.

Lysine demethylase 3A promotes chondrogenic differentiation of aged human dental pulp stem cells.

Background/purpose: Aging severely impairs the beneficial effects of human dental pulp stem cells (hDPSCs) on cartilage regeneration. Lysine demethylase 3A (KDM3A) is involved in regulating mesenchymal stem cells (MSCs) senescence and bone aging. In this study, we investigated the role of KDM3A in hDPSCs aging and whether KDM3A could rejuvenate aged hDPSCs to enhance their chondrogenic differentiation capacity.

Photo-Controlled Calcium Overload from Endogenous Sources for Tumor Therapy.

Designing reactive calcium-based nanogenerators to produce excess calcium ions (Ca ) in tumor cells is an attractive tumor treatment method. However, nanogenerators that introduce exogenous Ca are either overactive incapable of on-demand release, or excessively inert incapable of an overload of calcium rapidly. Herein, inspired by inherently diverse Ca -regulating channels, a photo-controlled Ca nanomodulator that fully utilizes endogenous Ca from dual sources was designed to achieve Ca overload in tumor cells.

Deletion in 1p36.33-p36.32 is associated with pancytopenia: a case report.

Background: 1P36 deletion syndrome is recognized as the most common terminal microdeletion syndrome in humans, characterized by early developmental delay and consequent intellectual disability, seizure disorder, and distinctive facial features. Variable deletion locations may attributed to phenotypic variability. However, the abnormal phenotypes of hematology are rarely reported in 1P36 deletion syndrome patients.

Nanofibers in Organelles: From Structure Design to Biomedical Applications.

Nanofibers are one of the most important morphologies of molecular self-assemblies, the formation of which relies on the diverse intermolecular interactions of fibrous-forming units. In the past decade, rapid advances have been made in the biomedical application of nanofibers, such as bioimaging and tumor treatment. An important topic to be focused on is not only the nanofiber formation mechanism but also where it forms, because different destinations could have different influences on cells and its formation could be triggered by unique stimuli in organelles.

A d-Methionine-Bonded Nanosized Heteropolyoxotungstate with Photocoloration.

A d-methionine-bonded nanosized arsenotungstate, BaKH[{AsWO(HO)}{AsWO}{WO(HO)(d-Met)}{WO(OH)(d-Met)}]·60HO [; d-Met = d-methionine (CHNOS)], is constructed without the use of lanthanide ions. The polyanion of contains two {AsWO(HO)} building blocks and two {B-β-AsWO} subunits, integrated together with a {WO(OH)(d-Met)} and two {WO(HO)(d-Met)} subclusters. Interestingly, displays a highly reversible photocoloration property with a half-life () time measured as about 0.

Lysine 68 Methylation-Dependent SOX9 Stability Control Modulates Chondrogenic Differentiation in Dental Pulp Stem Cells.

Dental pulp stem cells (DPSCs), characterized by easy availability, multi-lineage differentiation ability, and high proliferation ability, are ideal seed cells for cartilage tissue engineering. However, the epigenetic mechanism underlying chondrogenesis in DPSCs remains elusive. Herein, it is demonstrated that KDM3A and G9A, an antagonistic pair of histone-modifying enzymes, bidirectionally regulate the chondrogenic differentiation of DPSCs by controlling SOX9 (sex-determining region Y-type high-mobility group box protein 9) degradation through lysine methylation.

Integrated Single-Cell and Transcriptome Sequencing Analyses Identify Dipeptidase 2 as an Immune-Associated Prognostic Biomarker for Lung Adenocarcinoma.

Dipeptidase 2 (DPEP2) is a dipeptidyl peptidase that plays an important role in the hydrolysis of leukotriene D4 (LTD4) to leukotriene E4 (LTE4). Previous studies have suggested that LTD4 promotes tumor progression and survival in non-small cell lung cancer (NSCLC). Therefore, we hypothesized that DPEP2 may play a pivotal role in this tumor.

Alveolar bone morphology in patients with palatally-displaced maxillary lateral incisors before and after orthodontic treatment: A cone-beam computed tomography study.

Introduction: Palatal displacement of maxillary anterior teeth is common in clinical practice. Previous studies have reported that the labial bone around palatally-displaced incisors is thinner than that around normally-placed teeth. Therefore, it is necessary to elucidate alveolar bone changes after alignment to guide orthodontic treatment.

Quantitative prediction of ternary mixed gases based on an SnO sensor array and an SSA-BP neural network model.

This paper describes a tin oxide and copper doped tin oxide gas sensing material synthesized by a biological template method and simple hydrothermal reaction, which were used for the preparation of a gas sensor array. The sensor array is combined with the Sparrow Search Algorithm optimized BP neural network algorithm (SSA-BP) to predict and analyze the concentration of indoor toxic gases, including ammonia, xylene, and formaldehyde. Granular SnO was prepared by the biological template method and Cu/SnO doped with different copper ion concentrations was prepared by the hydrothermal method.

The role of non-steroidal anti-inflammatory drugs as adjuncts to periodontal treatment and in periodontal regeneration.

Periodontitis is the sixth most prevalent chronic disease globally and places significant burdens on societies and economies worldwide. Behavioral modification, risk factor control, coupled with cause-related therapy have been the "gold standard" treatment for managing periodontitis. Given that host inflammatory and immunological responses play critical roles in the pathogenesis of periodontitis and impact treatment responses, several adjunctive strategies aimed at modulating host responses and improving the results of periodontal therapy and maintenance have been proposed.