Recent studies challenge the dogma that a 21-mer phosphopeptide P140 protects against direct cell damage in the phase-III clinical trial (NCT02504645) for lupus, involving reactive oxygen species (ROS)-dependent release of citrullinated histone H3 (H3cit)-linked neutrophil extracellular traps. An open question is the cellular location of ROS production and H3cit formation in lupus. In this study, we examined the effects of P140 peptides on ROS production and H3cit location in lupus with in vivo and situ fluorescence imaging with subcellular resolution.
View Article and Find Full Text PDFIEEE Trans Neural Netw Learn Syst
November 2023
Chemical species tomography (CST) has been widely used for in situ imaging of critical parameters, e.g., species concentration and temperature, in reactive flows.
View Article and Find Full Text PDFEvol Psychol
January 2017