Publications by authors named "Yunendah Nur Fuadah"

Article Synopsis
  • - The CiPA initiative is working to better predict the risk of torsades de pointes (TdP) related to drug use by using computational models and explainable artificial intelligence (XAI) to analyze in-silico biomarkers and their impact on drug toxicity.
  • - The study created a dataset of 28 drugs and computed twelve in-silico biomarkers, training several machine learning models (like ANN and SVM) to predict toxicity risks, finding that the ANN model performed the best overall in classification accuracy.
  • - Using the SHAP method, the researchers were able to identify which biomarkers significantly contributed to the toxicity predictions, but they noted that biomarker selection didn't always enhance model performance, emphasizing the need to evaluate multiple classifiers
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Article Synopsis
  • - This study focuses on improving the assessment of drug-induced torsades de pointes (TdP) risk, which is crucial for drug development due to potential arrhythmias and sudden cardiac death.
  • - It introduces a stacking ensemble machine learning model that combines various biomarkers and hERG dynamics, achieving high accuracy in predicting risk levels associated with TdP.
  • - The research also looks into the variability among individuals by using data from different human ventricular cell models and identifies critical ion channels that significantly impact TdP risk prediction.
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Continuous blood pressure (BP) monitoring is essential for managing cardiovascular disease. However, existing devices often require expert handling, highlighting the need for alternative methods to simplify the process. Researchers have developed various methods using physiological signals to address this issue.

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Predicting ventricular arrhythmia Torsade de Pointes (TdP) caused by drug-induced cardiotoxicity is essential in drug development. Several studies used single biomarkers such as qNet and Repolarization Abnormality (RA) in a single cardiac cell model to evaluate TdP risk. However, a single biomarker may not encompass the full range of factors contributing to TdP risk, leading to divergent TdP risk prediction outcomes, mainly when evaluated using unseen data.

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Researchers commonly use continuous noninvasive blood-pressure measurement (cNIBP) based on photoplethysmography (PPG) signals to monitor blood pressure conveniently. However, the performance of the system still needs to be improved. Accuracy and precision in blood-pressure measurements are critical factors in diagnosing and managing patients' health conditions.

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Heart-sound auscultation is one of the most widely used approaches for detecting cardiovascular disorders. Diagnosing abnormalities of heart sound using a stethoscope depends on the physician's skill and judgment. Several studies have shown promising results in automatically detecting cardiovascular disorders based on heart-sound signals.

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Hypertension is a severe public health issue worldwide that significantly increases the risk of cardiac vascular disease, stroke, brain hemorrhage, and renal dysfunction. Early screening of blood pressure (BP) levels is essential to prevent the dangerous complication associated with hypertension as the leading cause of death. Recent studies have focused on employing photoplethysmograms (PPG) with machine learning to classify BP levels.

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Cardiovascular disorders, including atrial fibrillation (AF) and congestive heart failure (CHF), are the significant causes of mortality worldwide. The diagnosis of cardiovascular disorders is heavily reliant on ECG signals. Therefore, extracting significant features from ECG signals is the most challenging aspect of representing each condition of ECG signal.

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