Publications by authors named "Yune Zhao"
Introduction: Cataract surgery has been reported to have a reducing effect on intraocular pressure (IOP) in glaucomatous and non-glaucomatous eyes. This effect seems to be more noticeable in eyes with narrow angles (NAs) than in eyes with open angles (OAs). Decrease in IOP may be a result of the increase in anterior chamber angle (ACA) and Schlemm canal (SC) after cataract surgery.
View Article and Find Full Text PDFPurpose: To observe and explore the correlation between visual outcomes and intraocular lens (IOL) stability after tri-focal IOL implantation in eyes with high myopia.
Methods: Patients with highly myopic cataract (axial length > 26 mm) were enrolled in this prospective study. Thirty-one eyes (31 patients) received implantation of a trifocal IOL (AcrySof IQ PanOptix TFNT00).
Association analyses of the measurements of the photopic negative response evoked by two ISCEV protocols.
Graefes Arch Clin Exp Ophthalmol
December 2024
Purpose: To perform association analyses between the measurements of photopic negative response (PhNR) evoked by two ISCEV protocols.
Methods: A total of 172 eyes from 72 post-operative pediatric cataract patients and 24 healthy children were enrolled. The amplitude and peak time of PhNR were analyzed in three eye groups, 1.
Aim: To establish an animal model of form deprivation amblyopia based on a simulated cataract intraocular lens (IOLs).
Methods: Poly(dimethyl siloxane)-SiO thin films (PSF) with different degrees of opacity as IOL materials were prepared. The light transmission of the PSF-IOL was measured, and its biosafety was determined by cell counting kit (CCK)-8 assay using the HLEC-B3 cell line and ARPE-19 cell line.
Aim: To present a technique of transcapsular scleral fixation of the standard capsular tension ring (CTR) through equatorial capsulotomy and in-the-bag intraocular lens (IOL) implantation in subluxated lenses.
Methods: This retrospective consecutive case series included patients with subluxated lenses by more than 180 degrees who underwent lens extraction, transcapsular scleral fixation of the standard CTR through equatorial capsulotomy, in-the-bag IOL implantation and with at least 6mo follow-up. Preoperative and postoperative best corrected visual acuity (BCVA), intraocular pressure (IOP), complications, and postoperative IOL tilt and decentration were recorded.
Associations of light-adapted electroretinogram in paediatric amblyopia.
Ophthalmic Physiol Opt
December 2024
Purpose: The aim of this study was to investigate changes in the light-adapted (LA) electroretinogram (ERG) associated with paediatric amblyopia.
Method: A total of 220 eyes from 81 postoperative paediatric cataract patients and 29 healthy children were enrolled in four groups, namely controls, unilaterally amblyopic eyes, non-amblyopic fellow eyes and bilaterally affected eyes. Differences in LA ERG variables (peak time and amplitude of a- and b-waves and photopic negative response [PhNR]) were compared across groups, as well as their associations with visual acuity and changes in axial length.
Enhanced intracellular calcium detection using dopamine-modified graphene quantum dots with dual emission mechanisms.
Spectrochim Acta A Mol Biomol Spectrosc
March 2025
Article Synopsis
- - The study presents dopamine-functionalized graphene quantum dots (DA-GQDs) as an innovative fluorescence sensor that detects calcium ions (Ca) with high selectivity and sensitivity, showing enhanced fluorescence intensity upon Ca addition.
- - The mechanisms behind the sensor's performance involve photoinduced electron transfer and the coordination of Ca with oxygen groups on DA-GQDs, leading to a low detection limit of 0.05 µM and a linear response range of 4.93-10.61 µM.
- - Importantly, DA-GQDs remain non-toxic and biocompatible, making them suitable for imaging intracellular Ca, while effectively distinguishing Ca from other ions despite the presence of chelating agents.
Posterior capsule opacification (PCO) due to the proliferation and migration of lens epithelial cells (LECs) is the main complication after surgery. Heat stress has demonstrated impressive results in halting cell proliferation and migration, while also facilitating cell death. This study aimed to investigate the role and mechanism of ferroptosis in the proliferation and migration of LECs under heat stress.
View Article and Find Full Text PDFAssociation Analysis of Telomere Length and Vision in a Large Community-Based Survey.
Ophthalmic Epidemiol
November 2024
Purpose: To investigate whether there is a direct, age-independent association between telomere length and visual acuity decline in a large community-based cohort study.
Methods: Participants older than 40 with linked leukocyte telomere length (LTL) were enrolled in NHANES. LTL was assayed using qPCR from the participants' blood samples.
Purpose: To explore the application and potential ferroptosis mechanisms of sonodynamic therapy (SDT) using titanium dioxide nanoparticles (TiO2-NPs) as sonosensitizers for the prevention of posterior capsule opacification (PCO).
Methods: We fabricated TiO2-NP-coated intraocular lenses (TiO2-IOLs) using the spin-coating method, followed by ultrasound activation of the photosensitizer TiO2. In vitro experiments were performed with human lens epithelial cells (HLECs) to explore the appropriate concentration of TiO2 and ultrasonic parameters.
Article Synopsis
- - This study assessed how cataract surgery affects the corneal endothelium and central corneal thickness (CCT) in children, comparing results to a control group.
- - Results showed that after surgery, children with bilateral cataracts had a decrease in endothelial cell density (CD) and increases in average cell area (AVE) and CCT, while similar changes were observed in the unilateral cataract group.
- - The study also found that more corneal sutures and smaller pupil diameters correlated with worse corneal health outcomes in the unilateral cataract group.
Article Synopsis
- The study aimed to compare the effects of 8 mm and 9 mm optical zone diameters on correcting corneal astigmatism during cataract surgery with femtosecond laser corneal relaxing incisions (CRIs).
- Results showed that the 8 mm optical zone significantly reduced postoperative corneal astigmatism (0.77 D) more than the 9 mm zone (0.42 D) and had better outcomes in terms of correction index and astigmatism control.
- The 9 mm group had deeper incisions (79.30%) compared to the 8 mm group (72.58%), indicating that shallower incisions in the 8 mm group were
Article Synopsis
- Keratitis is a major cause of blindness globally, particularly challenging due to drug-resistant bacteria and biofilm formation that can lead to severe outcomes like eyeball removal.
- Researchers developed a new treatment method called mild photothermal loop (MPL) therapy, which effectively kills methicillin-resistant Staphylococcus aureus (MRSA) at a specific temperature and duration.
- They also created a dual-purpose hydrogel that not only combats MRSA but also reduces harmful compounds and inflammation, showing promising results in both lab tests and animal studies, marking a novel approach for treating refractory keratitis.
Article Synopsis
- The study aimed to assess how a capsular tension ring (CTR) impacts the stability of the intraocular lens (IOL) after cataract surgery in patients with long axial lengths.
- The research included 43 patients and measured various indicators, such as postoperative aqueous depth and lens position, using advanced imaging over three months.
- Results showed that CTR significantly improved IOL stability and reduced decentration post-surgery compared to those who didn't receive the CTR, while not impacting refractive outcomes.
Using nitrogen-doped graphene quantum dots (N-GQDs) and 3-aminophenylboronic acid (APBA), a novel fluorescence nanosensor was developed. This nanosensor exhibits high selectivity and sensitivity for lysine detection. Its sensing mechanism involves the suppression of electron transfer from APBA to the N-GQDs unit, thereby inhibiting photoinduced electron transfer and initiating internal charge transfer.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates postoperative outcomes and axial length growth in infants with congenital cataracts and microphthalmos who underwent cataract surgery.
- It compares two groups: one with microphthalmos and a control group, revealing a higher incidence of glaucoma in the microphthalmos group and slower axial length growth compared to controls.
- Early surgery improved visual function for both groups, but infants with microphthalmos experienced more complications despite similar visual acuity improvements.
Purpose: To evaluate the ability of swept-source optical coherence tomography angiography (SS-OCTA) to assess lid margin vascularity.
Methods: This prospective, cross-sectional trial enrolled 125 participants, including 15 control subjects and 110 meibomian gland dysfunction (MGD) patients. Lid margin blood flow density (LMBFD) was obtained using SS-OCTA.
Purpose: To evaluate the predictive accuracy of modern intraocular lens (IOL) formulas and axial length (AL) adjusted traditional IOL formulas, including Wang-Koch and Cooke-modified AL (CMAL) method, in long eyes with plate-haptic IOLs, and to compare refractive prediction error variances with C-loop IOLs.
Design: Retrospective consecutive case series study.
Methods: Data from 391 eyes with Zeiss 509 M and 302 eyes with Alcon SN6CWS implants in highly myopic patients, following cataract surgery from January 2019 to November 2023, were collected.
Introduction: The aim of this work is to investigate the dynamic changes of capsular-intraocular lens (IOL) adhesion in plate-haptic hydrophilic and loop-haptic hydrophobic eyes.
Methods: Cataract eyes that met the inclusion criteria were randomly assigned to receive implantation of a plate-haptic hydrophilic or loop-haptic IOL. The anterior capsular adhesion, posterior capsular adhesion, and the configurations of the capsular bend were evaluated using swept-source optical coherence tomography at 1 day, 1 week, 1 month, and 3 months postoperatively.
Introduction: The aim of this work is to evaluate the accuracy of the Barrett Universal II (BU II), Emmetropia verifying optical (EVO) 2.0, Haigis, Hoffer Q, Hoffer QST (Savini/Taroni) (HQST), Holladay 1, Kane, Ladas Super, Sanders-Retzlaff-Kraff/theoretical (SRK/T), and T2 intraocular lens (IOL) power formulas for calculating spherical equivalent (SE) of toric IOL.
Methods: This study enrolled consecutive patients who underwent phacoemulsification and toric IOL implantation at the Eye Hospital of Wenzhou Medical University in Hangzhou from 2015 to 2022.
Objectives: To investigate the characteristic cytokine profile of the aqueous humor in eyes with congenital cataract and pre-existing posterior capsule dysfunction (PCD).
Methods: In this cross-sectional study, the enrolled eyes with congenital cataract and PCD were included in the PCD group, while those with an intact posterior capsule were included in the control group. Demographic data and biometric parameters were recorded.
Aim: To investigate the efficacy of a new visual acuity (VA) screening method, the baby vision test for young children.
Methods: A total 105 eyes of 65 children aged 2-8y were included in the study. Acuity testing was conducted using a standardized recognition acuity chart (Snellen visual chart: at 3 m) and the baby vision model assessment.
Background And Aims: The National Standardized Training for Resident Doctors (STRD) in mainland China encounters many challenges in its implementation. To investigate whether outpatients are willing to undergo indirect ophthalmoscopy examination conducted by ophthalmology residents in the ophthalmology STRD program in China.
Methods: This study conducted a cross-sectional survey at the Eye Hospital of Wenzhou Medical University between September 2021 and September 2023.
Article Synopsis
- The study examines how anterior capsule polishing affects postoperative complications in patients with age-related cataracts.
- A total of 21 patients had one eye polished during surgery while the other served as a control for comparison of outcomes like capsule opacification and deformation over one year.
- Results indicated that polishing helped delay early capsular bag deformation and reduced contraction of the anterior capsule opening without increasing the risk of complications.