Effect of pore-throat structure on movable fluid and gas-water seepage in tight sandstone from the southeastern Ordos Basin, China.

This study investigates the micro-pore-throat structure of Upper Paleozoic tight sandstone gas reservoirs in the southeastern Ordos Basin, China, with a focus on the Yan'an gas field. The aim is to analyze the micro-pore-throat characteristics and their influence on fluid seepage to optimize gas-water two-phase flow, reservoir evaluation, and development strategies. The research integrates core analysis, thin section petrography, FE-SEM, MICP, NMR, and gas-water relative permeability tests.

A scale-down model of 4000-L cell culture process for inactivated foot-and-mouth disease vaccine production.

The anticipated increasing demand for inactivated foot-and-mouth (FMD) disease vaccine calls for its larger production capacity, while development of a large-scale process typically requires high running cost and has very limited experimental throughput at manufacturing scale. Thus, an economic scale-down model of representing a large-scale process becomes necessary and essential. In this study, we used a systematic approach to establish a scale-down model representing a 4000-L culture process for FMD vaccine production by suspension BHK-21 cells.

Quality by Design-Driven Process Development of Cell Culture in Bioreactor for the Production of Foot-And-Mouth Veterinary Vaccine.

Quality by design (QbD) principle has been established as a guideline to emphasize the understanding of the relationship of product quality with process control. Vaccine product have characteristics of security and high efficiency, but it also has features such as complexity and rigorous regulatory for production. This case study describes an example of QbD-driven process development for manufacturing a veterinary vaccine produced with baby hamster kidney-21 cells.