Ionic liquids as effective additives to enhance the solubility and permeation for puerarin and ferulic acid.

Ionic liquids, especially the cholinium-amino acid-based ionic liquids (CHAAILs), have recently been found to be effective ingredients in formulation of transdermal drug delivery system. In this work, we synthesized six CHAAILs, and investigated their ability to enhance the solubility and permeation of two active pharmaceutic ingredients (APIs), ferulic acid and puerarin. The solubility measurements showed that a low amount of CHAAILs can significantly increase the solubility of APIs.

Effect of baicalin on gestational hypertension-induced vascular endothelial cell damage.

Objective: Baicalin is a compound extracted from the dried root of Georgi. Studies have shown that baicalin has a protective effect on vascular endothelial cells, but whether baicalin could alleviate ascular endothelial cell damage in pregnancy-induced hypertensive patients remains unknown.

Materials And Methods: We established a hypertensive pregnant rat model to study vascular endothelial injury during pregnancy-induced hypertension.