Silencing of long non‑coding RNA NEAT1 inhibits hepatocellular carcinoma progression by downregulating SMO by sponging microRNA‑503.

Hepatocellular carcinoma (HCC) poses an increasing threat to humans, due to its poor prognosis. Nuclear‑enriched abundant transcript 1 (NEAT1), a type of long non‑coding (lnc)RNA, has been found to function in a variety of cancer types. However, the role of NEAT1 in HCC is poorly understood.

Phosphorus supply via a fed-batch strategy improves lipid heterotrophic production of Chlorella regularis.

Intracellular phosphorus (P) accumulation can improve microalgal growth and lipid synthesis. However, large excess of P causes cell poisoning. This study utilized a P-fed-batch strategy to investigate its potential to improve the utilization of the excessive P, while avoiding toxic side effects.

lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p.

Sepsis is a life-threatening condition and often associated with multiple organ failure. Nuclear-enriched abundant transcript 1 (NEAT1), a member of the long non-coding RNAs (lncRNAs), was reported to be involved in the regulation of sepsis progression. However, its precise regulatory mechanism needs to be further explored.

Synergistic effect and mechanisms of compound bioflocculant and AlCl3 salts on enhancing Chlorella regularis harvesting.

The high energy input required for harvesting microalgae means that commercial production of microalgal biodiesel is economically unfeasible. In this study, we investigated the flocculation efficiency and synergistic mechanisms of novel coupled flocculants, AlCl3 and compound bioflocculants (CBF), to overcome this difficulty. AlCl3 flocculation was found to be very sensitive to pH, and flocculation efficiency increased from 55 to 95 % when pH increased from 4 to 10.

Granulation, control of bacterial contamination, and enhanced lipid accumulation by driving nutrient starvation in coupled wastewater treatment and Chlorella regularis cultivation.

Bacterial contamination and biomass harvesting are still challenges associated with coupling of microalgae and wastewater treatment technology. This study investigated aggregation, bacterial growth, lipid production, and pollutant removal during bacteria contaminated Chlorella regularis cultivation under nutrient starvation stress, by supposing the C/N/P ratios of the medium to 14/1.4/1 (MB₂.

Nickel biosorption by discharged biomass from wastewater treatment bioreactor: size plays a key role.

Biomass size significantly affects the characteristics of the extracellular polymeric substances, which in turn influences the biosorption mechanisms. In this work, nickel biosorption mechanisms and the capacity of excess aerobic granules (AGs) of >850 μm, 500-850 μm, 212-500 μm, and bioflocs <212 μm, discharged during wastewater treatment operation, were investigated by elemental composition and spectroscopic analysis. Ni(2+) biosorption capacity decreased apparently from 1.