Advanced susceptibility analysis of ground deformation disasters using large language models and machine learning: A Hangzhou City case study.

To address the prevailing scenario where comprehensive susceptibility assessments of ground deformation disasters primarily rely on knowledge-driven models, with weight judgments largely founded on expert subjective assessments, this study initially explores the feasibility of integrating data-driven models into the evaluation of urban ground collapse and subsidence. Hangzhou city, characterized by filled soil and silty sand, was selected as the representative study area. Nine pertinent evaluation factors were identified, and the RF-BP neural network coupling model was employed to assess the susceptibility of ground collapse and subsidence in the study area, the results indicate that the stacked model achieved a 7% increase in AUC value compared to the single model.

Characterisation of the novel KIR2DL1*00308 allele identified in a Chinese Han individual.

The novel KIR2DL1*00308 allele differs from the closest allele KIR2DL1*00302 by a single sense mutation.

Association between Paraspinal Muscle Parameters and single-segment Degenerative Lumbar Spondylolisthesis: A Retrospective, cross-sectional Cohort Study.

Study Design: A retrospective, cross-sectional cohort study.

Objective: This study aims to investigate the association between paraspinal muscle parameters and single-segment degenerative lumbar spondylolisthesis (DLS).

Summary Of Background Data: The relationship between lumbar paraspinal muscles morphology and single-segment DLS remains unclear.

Coadministration of Quercetin and Indocyanine Green via PEGylated Phospholipid Micelles for Augmented Chem-Photothermal Combination Tumor Therapy.

A significant impediment persists in developing multicomponent nanomedicines designed to dismantle the heat shock protein (HSP)-based protective mechanism of malignant tumors during photothermal therapy. Herein, well-defined PEGylated phospholipid micelles were utilized to coencapsulate quercetin (QUE, a natural anticancer agent and potent HSP inhibitor) and indocyanine green (ICG, a photothermal agent) with the aim of achieving synchronized and synergistic drug effects. The subsequent investigations validated that the tailored micellar system effectively enhanced QUE's water solubility and augmented its cellular internalization efficiency.

Unraveling distinct effects between CuO and PtCu alloy sites in Pt-Cu bimetallic catalysts for CO oxidation at different temperatures.

In situ exploration of the dynamic structure evolution of catalysts plays a key role in revealing reaction mechanisms and designing efficient catalysts. In this work, PtCu/MgO catalysts, synthesized via the co-impregnation method, outperforms monometallic Pt/MgO and Cu/MgO. Utilizing quasi/in-situ characterization techniques, it is discovered that there is an obvious structural evolution over PtCu/MgO from PtCuO oxide cluster to PtCu alloy with surface CuO species under different redox and CO oxidation reaction conditions.

Generation and Characterization of Induced Pluripotent Stem Cells Carrying An ASXL1 Mutation.

Additional sex combs-like 1 (ASXL1) is an epigenetic modulator frequently mutated in myeloid malignancies, generally associated with poor prognosis. Current models for ASXL1-mutated diseases are mainly based on the complete deletion of Asxl1 or overexpression of C-terminal truncations in mice models. However, these models cannot fully recapitulate the pathogenesis of myeloid malignancies.

A single nucleotide substitution in exon 5 generated the novel KIR2DL3*00112 allele.

The novel KIR2DL3*00112 allele differs from the closest allele KIR2DL3*00101 by a single same sense mutation.

Combination Nano-Delivery Systems Remodel the Immunosuppressive Tumor Microenvironment for Metastatic Triple-Negative Breast Cancer Therapy.

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer for which effective therapies are lacking. Targeted remodeling of the immunosuppressive tumor microenvironment (TME) and activation of the body's immune system to fight tumors with well-designed nanoparticles have emerged as pivotal breakthroughs in tumor treatment. To simultaneously remodel the immunosuppressive TME and trigger immune responses, we designed two potential therapeutic nanodelivery systems to inhibit TNBC.

Phosphorus doped molybdenum disulfide regulated by sodium chloride for advanced supercapacitor electrodes.

As a pseudocapacitor electrode material, molybdenum disulfide (MoS) usually shows inferior capacity, rate capability and cyclability. Structural regulation and heteroatom doping are the available methods to ameliorate the electrochemical properties of MoS. Herein, phosphorus doped molybdenum disulfide regulated by sodium chloride (SP-MoS) is successfully synthesized using phosphomolybdate acid as a molybdenum source and an dopant and sodium chloride (NaCl) as a structural regulator.

Self-assembled molybdenum disulfide nanoflowers regulated by lithium sulfate for high performance supercapacitors.

Recently, molybdenum disulfide (MoS) has been extensively investigated as a promising pseudocapacitor electrode material. However, MoS usually exhibits inferior rate capability and cyclability, which restrain its practical application in energy storage. In this work, MoS nanoflowers regulated by LiSO (L-MoS) are successfully fabricated intercalating solvated Li ions.

Seeking a Hierarchical Prototype for Multimodal Gesture Recognition.

Gesture recognition has drawn considerable attention from many researchers owing to its wide range of applications. Although significant progress has been made in this field, previous works always focus on how to distinguish between different gesture classes, ignoring the influence of inner-class divergence caused by gesture-irrelevant factors. Meanwhile, for multimodal gesture recognition, feature or score fusion in the final stage is a general choice to combine the information of different modalities.

Non-Noble FeCrO Bimetallic Nanoparticles for Efficient NH Decomposition.

Ammonia has the advantages of being easy to liquefy, easy to store, and having a high hydrogen content of 17.3 wt%, which can be produced without CO through an ammonia decomposition using an appropriate catalyst. In this paper, a series of FeCr bimetallic oxide nanocatalysts with a uniform morphology and regulated composition were synthesized by the urea two-step hydrolysis method, which exhibited the high-performance decomposition of ammonia.

Bortezomib, Melphalan, and Prednisone With or Without Daratumumab in Transplant-ineligible Asian Patients With Newly Diagnosed Multiple Myeloma: The Phase 3 OCTANS Study.

Introduction: In the global phase 3 ALCYONE trial, daratumumab plus bortezomib/melphalan/prednisone (D-VMP) improved outcomes versus VMP in transplant-ineligible newly diagnosed multiple myeloma (NDMM) patients. Here, we report the primary analysis of the phase 3 OCTANS trial of D-VMP versus VMP in transplant-ineligible Asian NDMM patients.

Patients And Methods: In total, 220 patients were randomized (2:1) to receive 9 cycles of VMP (bortezomib 1.

Avidity-Based Method for the Efficient Generation of Monoubiquitinated Recombinant Proteins.

Monoubiquitination of proteins governs diverse physiological processes, and its dysregulation is implicated in multiple pathologies. The difficulty of preparing sufficient material often complicates the biophysical studies of monoubiquitinated recombinant proteins. Here we describe a robust avidity-based method that overcomes this problem.

Oxyhemoglobin-Based Nanophotosensitizer for Specific and Synergistic Photothermal and Photodynamic Therapies against Oral Infection.

Photothermal therapy (PTT) and photodynamic therapy (PDT) are emerging alternative antibacterial approaches. However, due to the lack of selectivity of photosensitizers for pathogenic bacteria, these methods often show more or less different degrees of toxicity. Moreover, it is difficult for PDT to exert effective antibacterial effects against anaerobic infections due to the oxygen deficiency.

Semi-Supervised Domain Alignment Learning for Single Image Dehazing.

Convolutional neural networks (CNNs) have attracted much research attention and achieved great improvements in single-image dehazing. However, previous learning-based dehazing methods are mainly trained on synthetic data, which greatly degrades their generalization capability on natural hazy images. To address this issue, this article proposes a semi-supervised learning approach for single-image dehazing, where both synthetic and realistic images are leveraged during training.

GltS regulates biofilm formation in methicillin-resistant Staphylococcus aureus.

Biofilm-based infection is a major healthcare burden. Methicillin-resistant Staphylococcus aureus (MRSA) is one of major organisms responsible for biofilm infection. Although biofilm is induced by a number of environmental signals, the molecule responsible for environmental sensing is not well delineated.

The miR-106b-25 cluster mediates drug resistance in myeloid leukaemias by inactivating multiple apoptotic genes.

Drug resistance is a major obstacle to the successful treatment of cancer. The role of the miR-106b-25 cluster in drug resistance of haematologic malignancies has not yet been elucidated. Here, we show that the miR-106b-25 cluster mediates resistance to therapeutic agents with structural and mechanistic dissimilarity in vitro and in vivo.

CD11c regulates neutrophil maturation.

Sepsis continues to be associated with high morbidity and mortality. Currently, sepsis is managed only conservatively. In sepsis, a substantial number of neutrophils is required, leading to accelerated neutrophil production.

Safety and efficacy of daratumumab in Chinese patients with relapsed or refractory multiple myeloma: a phase 1, dose-escalation study (MMY1003).

Daratumumab monotherapy demonstrated favorable safety and efficacy in relapsed/refractory multiple myeloma (RRMM) patients in the global phase 1/2 GEN501 and phase 2 SIRIUS studies. MMY1003 evaluated daratumumab monotherapy specifically in Chinese patients with RRMM. This 3-part, open-label, phase 1, dose-escalation study included patients with ≥ 2 prior lines of therapy.

NaCl-Templated Ultrathin 2D-Yttria Nanosheets Supported Pt Nanoparticles for Enhancing CO Oxidation Reaction.

Morphology of support is of fundamental significance to the fabrication of highly efficient catalysts for CO oxidation reaction. Many methods for the construction of supports with specific morphology and structures greatly rely on controlling general physical and chemical synthesis conditions such as temperature or pH. In this paper, we report a facile route to prepare yttria nanosheet using NaCl as template to support platinum nanoparticles exhibiting higher CO oxidation activity than that of the normally prepared Pt/YO.

growth of novel carbon nanobuds and nanoballs on graphene nanosheets by the electrochemical method.

Novel carbon nanostructures, carbon nanobuds and nanoballs grown on graphene, have been synthesized by the electrochemical method in this study. Pristine graphene (GR) sheets were potentiostatic treated with sulfuric acid and were oxidized at 1.4-2.

Multi-Scale Attention 3D Convolutional Network for Multimodal Gesture Recognition.

Gesture recognition is an important direction in computer vision research. Information from the hands is crucial in this task. However, current methods consistently achieve attention on hand regions based on estimated keypoints, which will significantly increase both time and complexity, and may lose position information of the hand due to wrong keypoint estimations.

iRGD Tumor-Penetrating Peptide-Modified Nano-Delivery System Based on a Marine Sulfated Polysaccharide for Enhanced Anti-Tumor Efficiency Against Breast Cancer.

Background: Breast cancer is a common malignancy in women. Conventional clinical therapies for breast cancer all display moderate clinical efficacies and limitations. It is urgent to explore the novel and combined therapeutic strategies for breast cancer to meet clinical demand.