Publications by authors named "Yuna Takahashi"
Hematopoietic stem cells (HSCs) obtained from patient-derived human induced pluripotent stem cells (iPSCs) are a promising tool for curing various hematological disorders. We previously demonstrated that enforced expression of the LIM-homeobox transcription factor Lhx2, which is essential for mouse embryonic hematopoiesis, leads to generation of engraftable and expandable hematopoietic stem cells (HSCs) from mouse iPSCs. However, it remained unknown whether Lhx2 can induce HSCs from human iPSCs.
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- Conventional antipsychotic drugs are ineffective for about one-third of schizophrenia patients, highlighting the need for non-dopaminergic treatment options.
- A systematic review of recent phase II and III clinical trials identified 16 promising compounds for schizophrenia treatment, including both monotherapies and add-on therapies.
- Several of these compounds showed efficacy for various symptoms of schizophrenia, suggesting new, targeted treatment strategies that differ from traditional antipsychotics.*
Introduction: Whether psychiatric symptoms after recovery from coronavirus disease 2019 (COVID-19) are specific to this illness remains unclear.
Methods: In this retrospective study, the Diagnosis Procedure Combination data and outpatient clinic data were used for patients who received inpatient treatment in Saiseikai-affiliated hospitals for COVID-19 or other respiratory tract infections (non-COVID) from 2020 to 2022. The primary outcome was new prescriptions of psychotropic drugs after discharge (i.
Article Synopsis
- 'Globemaster' is a hybrid ornamental plant, and its bulbs were analyzed for their chemical compounds through a systematic study.
- The researchers isolated 27 steroidal glycosides from the bulbs, identifying various classes, including spirostanol and furostanol glycosides, using NMR spectroscopic data.
- Certain isolated compounds showed cytotoxic effects on various cancer cell lines, with specified inhibitory concentrations ranging from 1.3 to 49 µM.
The negative inotropic effects of nine Vaughan Williams class I antiarrhythmic drugs were examined in guinea pig ventricular tissue preparations. The drugs decreased the contractile force of papillary muscles with different potencies: the potency order was propafenone > aprindine > cibenzoline > flecainide > ranolazine > disopyramide > pilsicainide > mexiletine > GS-458967. The potency of drugs correlated with the reported IC values to block the L-type Ca channel rather than the Na channel.
View Article and Find Full Text PDFBrain histamine acts as a neurotransmitter in the regulation of various brain activities. Previous studies have shown that histamine N-methyltransferase (HNMT), a histamine-metabolizing enzyme, controls brain histamine concentration and brain function. However, the relative contribution of astrocytic or neuronal HNMT to the regulation of the histaminergic system is still inconclusive.
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