Publications by authors named "Yuna Nakagawa"
Article Synopsis
- The study focuses on how changes in cellular membrane shape are crucial for many biological processes, particularly through local curvature changes triggered by specific proteins like Epsin-1.
- Epsin-1's N-terminal segment, EpN18, is identified as key to creating these curvatures, with research revealing important structural features that influence this process.
- Findings highlight that hydrophobic residues, especially leucine, significantly enhance the membrane interaction and curvature induction of EpN18, potentially aiding in the delivery of other molecules into cells.
Macropinocytosis is a form of endocytosis that allows massive uptake of extracellular materials and is a promising route for intracellular delivery of biofunctional macromolecules and nanoparticles. Our laboratory developed a potent macropinocytosis-inducing peptide named P4A. However, the ability of this peptide is not apparent in the presence of serum.
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