KDM2A and KDM2B protect a subset of CpG islands from DNA methylation.

In the mammalian genome, most CpGs are methylated. However, CpGs within the CpG islands (CGIs) are largely unmethylated, which are important for gene expression regulation. The mechanism underlying the low methylation levels at CGIs remains largely elusive.

Papillary Thyroid Carcinoma: Correlation Between Molecular and Clinical Features.

Background: Thyroid cancer is prevalent worldwide, including in China, where its incidence is on the rise. Papillary thyroid carcinoma (PTC) is the predominant subtype. Investigating the relationship between clinical data associated with PTC and gene mutations is crucial for improving detection and treatment.

Graphene-Based Flexible Strain Sensor Based on PDMS for Strain Detection of Steel Wire Core Conveyor Belt Joints.

Because of their superior performance, flexible strain sensors are used in a wide range of applications, including medicine and health, human-computer interaction, and precision manufacturing. Flexible strain sensors outperform conventional silicon-based sensors in high-strain environments. However, most current studies report complex flexible sensor preparation processes, and research focuses on enhancing and improving one parameter or property of the sensors, ignoring the feasibility of flexible strain sensors for applications in various fields.

Screening biomarkers for predicting the efficacy of immunotherapy in patients with PD-L1 overexpression.

Purpose: Immunotherapy plays an important role in non-small cell lung cancer (NSCLC); in particular, immune checkpoint inhibitors (ICIs) therapy has good therapeutic effects in PD-L1-positive patients. This study aims to screen NSCLC patients with PD-L1-positive expression and select effective biomarkers for ICI immunotherapy.

Methods: Collected tumor samples from the Affiliated Cancer Hospital of Xinjiang Medical University and 117 patients with stage III-IV NSCLC were included in the study.

The Effect of Rainfall on Aquatic Nitrogen and Phosphorus in a Semi-Humid Area Catchment, Northern China.

The impact of rainfall on water quality may be more important in semi-arid regions, where rainfall is concentrated over a couple of months. To explore the impact of rainfall changes on water quality, e.g.

H3K27me3 shapes DNA methylome by inhibiting UHRF1-mediated H3 ubiquitination.

DNA methylation and histone lysine tri-methylation at H3K27 (H3K27me3) are two chromatin modifications for transcriptional gene silencing, which play important roles in diverse biological processes, including cell fate determination and cell lineage commitment. These two marks are largely mutually exclusive and target distinct sets of genes in the mammalian genome. However, how H3K27me3 shapes the DNA methylome remains elusive.

Successive biochar amendment affected crop yield by regulating soil nitrogen functional microbes in wheat-maize rotation farmland.

Biochar has attracted increased attention because of its potential benefits for carbon sequestration, soil fertility, and contaminant immobilization. However, mechanism of long-term successive biochar amendment affected crop yield by regulating soil properties and nitrogen (N) functional microbes is still unclear by now. A field fixed experiment was carried out from 2011 to 2018 that aimed to study the effects of successive biochar on soil properties, soil nitrogen functional microbial genes, and grain yield in wheat and maize rotation farmland in Northern China.

Root and nitrate-N distribution and optimization of N input in winter wheat.

Scientific management of nitrogen (N) fertilizer has a significant effect on yield while also reducing the environmental risks. In this study, we conducted field experiments over three years at two different sites (Zhengzhou and Shangshui) in Henan Province, China, using different N application rates (0, 90,180, 270, and 360 kg ha) to determine the relationships between soil N supply and N demand in winter wheat (Triticum aestivum L.).

Optimizing nitrogen management to achieve high yield, high nitrogen efficiency and low nitrogen emission in winter wheat.

Achieving both high yield and high nitrogen (N) use efficiency (NUE) simultaneously is a current research hotspot in crop production. To investigate approaches for achieving high yield and NUE, field experiments using N fertilizer rates of 0, 120, 180, 240, 300 and 360 kg N ha were conducted to study relationships between yield, N uptake and N efficiency during three wheat growing seasons from 2013 to 2016 in three experimental sites (Shangshui, Kaifeng and Wenxian) in the Huang-Huai Plain. Yield, biomass and N concentrations of plants and soil were determined.

Approach to Higher Wheat Yield in the Huang-Huai Plain: Improving Post-anthesis Productivity to Increase Harvest Index.

Both increased harvest index (HI) and increased dry matter (DM) are beneficial to yield; however, little is known about the priority of each under different yield levels. This paper aims to determine whether HI or DM is more important and identify the physiological attributes that act as indicators of increased yield. Two field experiments involving different cultivation patterns and water-nitrogen modes, respectively, were carried out from 2013 to 2016 in Huang-Huai Plain, China.

Remotely Estimating Aerial N Uptake in Winter Wheat Using Red-Edge Area Index From Multi-Angular Hyperspectral Data.

Remote sensing techniques can be efficient for non-destructive, rapid detection of wheat nitrogen (N) nutrient status. In the paper, we examined the relationships of canopy multi-angular data with aerial N uptake of winter wheat ( L.) across different growing seasons, locations, years, wheat varieties, and N application rates.

Grain number responses to pre-anthesis dry matter and nitrogen in improving wheat yield in the Huang-Huai Plain.

Wheat yield components vary between different ecological regions and yield levels. Grain number responses to pre-anthesis dry matter (DM) and nitrogen (N) in increasing yield were always investigated in spike organs, neglecting the effect of non-spike organ nutrition or overall distribution. This paper determined the relationships between grain number and pre-anthesis DM and N in spike and non-spike organs under different yield levels, with using two sorts of field experiments (different water-nitrogen modes and cultivation management patterns) from 2012-2015 in Huang-Huai plain.

Effect of irrigation and nitrogen application on grain amino acid composition and protein quality in winter wheat.

Water management and nitrogen application are critical factors in wheat grain yield and protein quality. This study aimed to evaluate the effect of irrigation and nitrogen application on the grain yield, protein content and amino acid composition of winter wheat. Field experiments were conducted in a split-plot design with three replications in high-yielding land on the North China Plain in 2012/2013, 2013/2014 and 2014/2015.

Wheat Grain Yield Increase in Response to Pre-Anthesis Foliar Application of 6-Benzylaminopurine Is Dependent on Floret Development.

Wheat yield is largely determined during the period prior to flowering, when the final numbers of fertile florets and grains per spike are established. The aim of this study was to assess the dynamics of floret primordia development in winter wheat in response to pre-anthesis application of a synthetic cytokinin, 6-benzylaminopurine (6-BA). We conducted an experiment in which two foliar spray treatments were applied (water or 6-BA) to Chinese winter wheat at 25 days after jointing during two growing seasons (2012-2013 and 2013-2014).

Nitrous Oxide Emission and Denitrifier Abundance in Two Agricultural Soils Amended with Crop Residues and Urea in the North China Plain.

The application of crop residues combined with Nitrogen (N) fertilizer has been broadly adopted in China. Crop residue amendments can provide readily available C and N, as well as other nutrients to agricultural soils, but also intensify the N fixation, further affecting N2O emissions. N2O pulses are obviously driven by rainfall, irrigation and fertilization.

[Effect of sulfur on the species of Fe and As under redox condition in paddy soil].

Redox conditions of the polluted paddy soil with exogenous As were simulated by redox reaction apparatus after flowing N2 and O2 applied with different forms of inorganic sulfur(CK-S0, elemental sulfur-S1 and sulfate-S2). Results showed that redox potential (Eh) was about -100 - -200 mV and the pH 7.0-8.

[Influence of sulfur on the bioavailability of arsenic uptake by rice (Oryza. sativa L. ) and its speciation in soil ].

Pot experiments using exogenous arsenic-polluted paddy soils were carried out to investigate the influence of different forms of sulfur fertilizers (sulfur and gypsum) on As uptake by rice and its chemical speciation. Soil solution pH value ranged 7. 38-7.

Producing more grain with lower environmental costs.

Agriculture faces great challenges to ensure global food security by increasing yields while reducing environmental costs. Here we address this challenge by conducting a total of 153 site-year field experiments covering the main agro-ecological areas for rice, wheat and maize production in China. A set of integrated soil-crop system management practices based on a modern understanding of crop ecophysiology and soil biogeochemistry increases average yields for rice, wheat and maize from 7.

Ultrastructural observation of mesophyll cells and temporal expression profiles of the genes involved in transitory starch metabolism in flag leaves of wheat after anthesis.

Transitory starch in cereal plant leaves is synthesized during the day and remobilized at night to provide a carbon source for growth and grain filling, but its mechanistic basis is still poorly understood. The objective of this study is to explore the regulatory mechanism for starch biosynthesis and degradation in plant source organs. Using transmission electron microscopy, we observed that during the day after anthesis, starch granules in mesophyll cells of wheat flag leaves accumulated in chloroplasts and the number of starch granules gradually decreased with wheat leaf growth.

Increasing the starch content and grain weight of common wheat by overexpression of the cytosolic AGPase large subunit gene.

ADP-glucose pyrophosphorylase (AGPase) catalyzes the first committed step of starch synthesis. AGPase is a heterotetramer composed of two large subunits and two small subunits, has cytosolic and plastidial isoforms, and is detected mainly in the cytosol of endosperm in cereal crops. To investigate the effects of AGPase cytosolic large subunit gene (LSU I) on starch biosynthesis in higher plant, in this study, a TaLSU I gene from wheat was overexpressed under the control of an endosperm-specific promoter in a wheat cultivar (Yumai 34).

Molecular cloning and expression analysis of the starch-branching enzyme III gene from common wheat (Triticum aestivum ).

The starch-branching enzyme (SBE) catalyzes the formation of branch points by cleaving the α-1,4 linkage in polyglucans and reattaching the chain via an α-1,6 linkage. Three types of SBE isoforms (SBEI, SBEII, and SBEIII) exist in higher plants, with the number of SBE isoforms being species-specific. This study isolated the SBEIII cDNA sequence (3,780 bp), designated TaSBEIII (accession no.

Proteomics reveals the effects of salicylic acid on growth and tolerance to subsequent drought stress in wheat.

Pretreatment with 0.5 mM salicylic acid (SA) for 3 days significantly enhanced the growth and tolerance to subsequent drought stress (PEG-6000, 15%) in wheat seedlings, manifesting as increased shoot and root dry weights, and decreased lipid peroxidation. Total proteins from wheat leaves exposed to (i) 0.

Proteomic analysis on salicylic acid-induced salt tolerance in common wheat seedlings (Triticum aestivum L.).

The influence of salicylic acid (SA) on the salt tolerance mechanism in seedlings of common wheat (Triticum aestivum L.) was investigated using physiological measurements combined with global expression profiling (proteomics). In the present study, 0.

[Effects of combined application of biogas slurry and chemical fertilizer on winter wheat rhizosphere soil microorganisms and enzyme activities].

This paper studied the effects of combined application of biogas slurry and chemical fertilizer under same N application rate on the quantities of bacteria, actinomycetes and fungi as well as the activities of urease, protease and catalase in winter wheat rhizosphere soil. With the growth of winter wheat, the quantities of test microorganisms and the activities of urease and catalase showed a trend of increasing after an initial decrease, while the protease activity showed an S-type change. Combined application of biogas slurry and chemical fertilizer increased the quantities of test microorganisms significantly, and improved the activities of soil urease and protease.

[Effects of nitrogen fertilization on population dynamics and yield of high-yielding wheat and on alteration of soil nitrogen].

Taking wheat varieties Yumai 49-198 (multi-spike phenotype) and Lankao Aizao 8 (large-spike phenotype) as test materials, field experiments were conducted at Wenxian and Lankao sites of Henan Province to study the effects of nitrogen fertilization on their population dynamics and yield and on the alteration of soil nitrogen. Five nitrogen application rates, i. e.