Impact of thrombocytopenia on failure of endoscopic variceal treatment in cirrhotic patients with acute variceal bleeding.

Background: Acute variceal bleeding (AVB), a life-threatening complication of liver cirrhosis, can be effectively treated by endoscopy, but there is a risk of early rebleeding after endoscopic variceal treatment (EVT). Thrombocytopenia is the most common hemostatic abnormality in liver cirrhosis. However, it is still unclear about whether thrombocytopenia increases the failure of EVT in cirrhotic patients with AVB.

Timing of endoscopy in cirrhotic patients with acute variceal bleeding: protocol of a multicenter randomized controlled trial.

Background: Endoscopy is important for the diagnosis and treatment of acute upper gastrointestinal bleeding (AUGIB), especially acute variceal bleeding (AVB), in liver cirrhosis. However, the optimal timing of endoscopy remains controversial, primarily because the currently available evidence is of poor quality, and the definition of early endoscopy is also very heterogeneous among studies. Herein, a multicenter randomized controlled trial (RCT) is performed to explore the impact of the timing of endoscopy on the outcomes of cirrhotic patients with AVB.

Impact of peptic ulcer bleeding on the in-hospital outcomes of cirrhotic patients with acute gastrointestinal bleeding: an international multicenter study.

Objectives: Peptic ulcer is the most common source of non-variceal bleeding. However, it remains controversial whether the outcomes of cirrhotic patients with peptic ulcer bleeding differ from those with variceal bleeding.

Methods: Cirrhotic patients with acute gastrointestinal bleeding (AGIB) who underwent endoscopy and had an identifiable source of bleeding were retrospectively screened from an international multicenter cohort.

Timing of endoscopy for acute variceal bleeding in patients with cirrhosis (CHESS1905): A nationwide cohort study.

Background: Endoscopy plays an important role in the management of acute variceal bleeding (AVB) in patients with cirrhosis. This study aimed at determining the optimal endoscopy timing for cirrhotic AVB.

Methods: Patients with cirrhosis with AVB across 34 university hospitals in 30 cities from February 2013 to May 2020 who underwent endoscopy within 24 hours were included in this study.

Practice guidance for the use of terlipressin for liver cirrhosis-related complications.

Background: Liver cirrhosis is a major global health burden worldwide due to its high risk of morbidity and mortality. Role of terlipressin for the management of liver cirrhosis-related complications has been recognized during recent years. This article aims to develop evidence-based clinical practice guidance on the use of terlipressin for liver cirrhosis-related complications.

Treatment Strategies in Emergency Endoscopy for Acute Esophageal Variceal Bleeding (CHESS1905): A Nationwide Cohort Study.

Background And Aims: Emergency endoscopy is recommended for patients with acute esophageal variceal bleeding (EVB) and their prognosis has improved markedly over past decades due to the increased specialization of endoscopic practice. The study aimed to compare outcomes following emergency endoscopic injection sclerotherapy (EIS) and endoscopic variceal ligation (EVL) in cirrhotic patients with acute EVB.

Methods: Cirrhotic patients with acute EVB who underwent emergency endoscopy were retrospectively enrolled from 2013 to 2020 across 34 university hospitals from 30 cities.

Acute kidney injury defined by cystatin C may be superior for predicting the outcomes of liver cirrhosis with acute gastrointestinal bleeding.

Background & Aims: Acute kidney injury (AKI) is conventionally evaluated by a dynamic change of serum creatinine (Scr). Cystatin C (CysC) seems to be a more accurate biomarker for assessing kidney function. This retrospective multicenter study aims to evaluate whether AKI re-defined by CysC can predict the in-hospital outcomes of patients with liver cirrhosis and acute gastrointestinal bleeding.

Effect of Body Mass Index on the Prognosis of Liver Cirrhosis.

At present, the association of body mass index (BMI) with the prognosis of liver cirrhosis is controversial. Our retrospective study aimed to evaluate the impact of BMI on the outcome of liver cirrhosis. In the first part, long-term death was evaluated in 436 patients with cirrhosis and without malignancy from our prospectively established single-center database.

Epidemiological and clinical characteristics of 65 hospitalized patients with COVID-19 in Liaoning, China.

Background: Coronavirus disease 2019 (COVID-19) has spread rapidly to multiple countries through its infectious agent severe acute respiratory syndrome coronavirus 2. The severity, atypical clinical presentation, and lack of specific anti-viral treatments have posed a challenge for the diagnosis and treatment of COVID-19. Understanding the epidemiological and clinical characteristics of COVID-19 cases in different geographical areas is essential to improve the prognosis of COVID-19 patients and slow the spread of the disease.

Epidemiological and clinical characteristics of fifty-six cases of COVID-19 in Liaoning Province, China.

Background: Pneumonia of uncertain cause has been reported in Wuhan, China since the beginning of early December 2019. In early January 2020, a novel strain of β-coronavirus was identified by the Chinese Center for Disease Control and Prevention from the pharyngeal swab specimens of patients, which was recently named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There is evidence of human-to-human transmission and familial cluster outbreak of SARS-CoV-2 infection.

Terlipressin May Decrease In-Hospital Mortality of Cirrhotic Patients with Acute Gastrointestinal Bleeding and Renal Dysfunction: A Retrospective Multicenter Observational Study.

Background: Acute gastrointestinal bleeding (GIB) rapidly reduces effective blood volume, thereby precipitating acute kidney injury (AKI). Terlipressin, which can induce splanchnic vasoconstriction and increase renal perfusion, has been recommended for acute GIB and hepatorenal syndrome in liver cirrhosis. Thus, we hypothesized that terlipressin might be beneficial for cirrhotic patients with acute GIB and renal impairment.

Serological detection of 2019-nCoV respond to the epidemic: A useful complement to nucleic acid testing.

Corona Virus Disease 2019 (COVID-19) has spread rapidly to more than 215 countries, with over 11.91 million reported cases and more than 540,000 deaths. Rapid diagnosis remains a bottleneck for containing the epidemic.

Effect of terlipressin on renal function in cirrhotic patients with acute upper gastrointestinal bleeding.

Background: Renal dysfunction is a serious morbidity in cirrhotic patients with acute upper gastrointestinal bleeding (AUGIB). Terlipressin is the first-line treatment choice for acute variceal bleeding and hepatorenal syndrome (HRS). This study aimed to assess the effect of terlipressin on renal function in patients with liver cirrhosis and AUGIB.

Development of hyponatremia after terlipressin in cirrhotic patients with acute gastrointestinal bleeding: a retrospective multicenter observational study.

: Terlipressin can effectively control acute gastrointestinal bleeding (GIB) in cirrhotic patients by acting on the V1 receptors, but may lead to the development of dilutional hyponatremia by acting on the V2 receptors.: This retrospective multicenter study enrolled 674 cirrhotic patients with acute GIB in whom serum sodium concentrations were tested before and during the use of terlipressin. ΔSodium reduction ≥5 mmol/L, hyponatremia (sodium <130 mmol/L), and severe hyponatremia (sodium <125 mmol/L) during the use of terlipressin were evaluated.

External validation of Liaoning score for predicting esophageal varices in liver cirrhosis: a Chinese multicenter cross-sectional study.

Background: Our previous study developed Liaoning score as a non-invasive approach for predicting esophageal varices (EVs) in liver cirrhosis. This nationwide multicenter cross-sectional study aimed to externally validate the diagnostic accuracy of Liaoning score and further evaluate its performance for predicting high-risk EVs.

Methods: Cirrhotic patients with acute gastrointestinal bleeding (GIB) without history of endoscopic variceal therapy who underwent endoscopic examinations at their admissions were included.

Development and Validation of CAGIB Score for Evaluating the Prognosis of Cirrhosis with Acute Gastrointestinal Bleeding: A Retrospective Multicenter Study.

Introduction: Acute gastrointestinal bleeding (GIB) is a major cause of death in liver cirrhosis. This multicenter study aims to develop and validate a novel and easy-to-access model for predicting the prognosis of patients with cirrhosis and acute GIB.

Methods: Patients with cirrhosis and acute GIB were enrolled and randomly divided into the training (n = 865) and validation (n = 817) cohorts.

Shaddock peels-based activated carbon as cost-saving adsorbents for efficient removal of Cr (VI) and methyl orange.

A simple and economical method was proposed to synthesize the shaddock peels-based activated carbon (SPAC) for their application as efficient sorbents to eliminate Cr (VI) and methyl orange (MO) from one-component and two-component systems. The synthesis was conducted via activation of phosphoric acid and high-temperature carbonization. The as-prepared SPAC was characterized by Brunauer-Emmett-Teller, scanning electron microscopy, energy dispersive X-ray spectroscopy, thermogravimetric analysis, X-ray diffraction, and Fourier transform infrared spectroscopy, among other techniques.

Characterization of EDTA-cross-linked β-cyclodextrin grafted onto Fe-Al hydroxides as an efficient adsorbent for methylene blue.

The synthesis process of Fe-Al hydroxides coated with ethylenediaminetetraacetic acid (EDTA)-cross-linked β-cyclodextrin polymer (FA-ECD) and its utilization in the adsorption of methylene blue (MB) were investigated. The FA-ECD before and after adsorption was characterized by scanning electron microscopy (SEM), Brunauer-Emmet-Teller (BET) analysis, Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric (TG) analysis, and X-ray diffraction (XRD). In addition, the EDTA and β-cyclodextrin contents were determined quantitatively.

Mechanisms of chromium and arsenite adsorption by amino-functionalized SBA-15.

The adsorption of Cr(VI) and As(III) by amino-functionalized SBA-15 (NH2-SBA-15) from single and binary systems were investigated in this work. The effects of pH and temperature on the adsorption of NH2-SBA-15 were studied. Adsorption kinetics, isotherm model, and thermodynamics were studied to analyze the experimental data.

Highly efficient treatment of industrial wastewater by solution plasma with low environmental load.

Advanced oxidation techniques are efficient processes to dispose of organic contaminants in industrial wastewater with low secondary pollution. The solution plasma technique was featured as an advanced oxidation technique with low secondary pollution and high efficiency. However, the solution plasma technique reported previously could only treat wastewater of less than 200 mL owing to the limited plasma generated by only one pair of electrodes.

Biosorption of heavy metal ions (Cu(2+), Mn (2+), Zn (2+), and Fe (3+)) from aqueous solutions using activated sludge: comparison of aerobic activated sludge with anaerobic activated sludge.

The potential of using two different kinds of air drying of activated sludge (aerobic activated sludge and anaerobic activated sludge) for the removal of Cu(2+), Mn(2+), Zn(2+), and Fe(3+) from aqueous solutions was assessed. Results indicated that the maximum biosorption occurred at pH = 5.0 for Cu(2+), Zn(2+), and Mn(2+) and pH = 3.

Comparative and competitive adsorption of Cr(VI), As(III), and Ni(II) onto coconut charcoal.

This study evaluates the behavior of coconut charcoal (AC) to adsorb Cr(VI), As(III), and Ni(II) in mono- and multicomponent (binary and ternary) systems. Batch experiments were carried out for mono- and multicomponent systems with varying metal ion concentrations to investigate the competitive adsorption characteristics. The adsorption kinetics followed the mechanism of the pseudo-second-order equation in both single and binary systems, indicating chemical sorption as the rate-limiting step of adsorption mechanism.

The characteristics of waste Saccharomyces cerevisiae biosorption of arsenic(III).

Purpose: The potential of using waste Saccharomyces cerevisiae as adsorbent for the adsorption of As(III) from aqueous solution was assessed.

Methods: The biosorbent was characterized by Fourier transform infrared (FTIR) spectroscopy analysis. Various parameters including pH, biosorbent dosage, contact time, and temperature were systematically investigated.