Multiple Enzymes Expressed by the Gut Microbiota Can Transform Typhaneoside and Are Associated with Improving Hyperlipidemia.

The mechanism of multiple enzymes mediated drug metabolism in gut microbiota is still unclear. This study explores multiple enzyme interaction process of typhactyloside (TYP) with gut microbiota and its lipid-lowering pharmacological activity. TYP, with bioavailability of only 2.

Biogeography of the Respiratory Tract Microbiome in Patients With Malignant Tracheal Tumors.

Background: This study aimed to characterize the bacterial microbiota in the oral cavity (OC), throat, trachea, and distal alveoli of patients with primary malignant tracheal tumors (PMTT), including squamous cell carcinoma (SCC) and salivary gland carcinoma patients (SGC), for comparison with a matched non-malignant tracheal tumor (NMTT) group.

Methods: Patients with pathological diagnosis of PMTT and NMTT were included in this study. Saliva, throat swab (TS), trachea protected specimen brush (PSB), and bronchoalveolar lavage fluid (BALF) samples were collected for 16S rRNA gene sequencing.

Polydopamine-induced tooth remineralization.

Inspired by mussel bioadhesion in nature, dopamine is extensively used for biomaterial surface modification. In this study, we coated dopamine on demineralized enamel and dentin surfaces to evaluate the effect of polydopamine coating on dental remineralization. Dental slices containing enamel and dentin were first etched with 37% phosphoric acid for 2 min, followed by immersion in a 2 mg/mL freshly prepared solution of dopamine (10 mM Tris buffer, pH 8.

[Primary malignant airway neoplasms in 4 children].

Objective: Primary airway neoplasms are extremely rare in the pediatric age group. This paper reports 4 children with primary airway neoplasms to explore the clinical manifestations, safety and efficacy of bronchoscopic interventions.

Method: The data of pathology, photographic documentation and imaging studies were analyzed.

[Endoscopic retrieval of metallic stents in patients with airway diseases].

Objective: To evaluate the indications, techniques, outcomes and complications of metallic stent removals in patients with airway disorders.

Methods: A retrospective analysis was performed in 43 patients with 47 tracheobronchial stents. The airway stent retrieval was performed under the guidance of rigid or flexible bronchoscopy between November 2005 and November 2009.

[Sealing of tracheoesophageal fistula using Sigma covered mental stents].

Objective: To explore the possibilities and efficiency of Sigma covered stents for the treatment of tracheoesophageal fistula (TEF).

Methods: Between 2006 and 2009, 10 Sigma covered mental stents had been placed by guidance of bronchoscopy and/or fluoroscopy in 8 patients with 9 tracheoesophageal fistulas. Among them, 7 fistulas were caused by cancer and 2 by mechanical damage.