[Mechanism of Transportation Capacity Influence on Carbon Emission of Transportation Sector at China Provincial Scale from a Spatial Perspectiv].

Transportation carbon emissions （TCE） are a major contributor to emissions, and their emission reduction pathway can provide recommendations for the overall carbon emission reduction decision-making. Therefore, identifying the impact mechanism of transportation capacity on TCE through scientific methods has become an important foundation to respond to the national "dual-carbon" strategy. Based on the panel data of 30 provinces in China from 2012 to 2021, a dynamic spatial dubin model （SDM） was included to empirically analyze the dynamic spatial spillover effects of transportation capacity on carbon emissions from China's transportation sector, taking correlation and heterogeneity into account.

Pulmonary hypertension- a novel phenotypic hypothesis of Kabuki syndrome: a case report and literature review.

Background: Pediatric pulmonary hypertension (PH) is a serious and rare disease that is often derived from genetic mutations. Kabuki syndrome (KS) is a chromosomal abnormality disease that has its origin in the mutation of lysine methyltransferase 2D(KMT2D). Recent evidence has shown that KMT2D mutations are associated with pediatric pulmonary disorders.

Xanthatin, a novel potent inhibitor of VEGFR2 signaling, inhibits angiogenesis and tumor growth in breast cancer cells.

Anti-angiogenesis targeting vascular endothelial growth factor receptor 2 (VEGFR2) has emerged as an important tool for cancer treatment. In this study, we described a novel VEGFR2 inhibitor, xanthatin, which inhibits tumor angiogenesis and growth. The biochemical profiles of xanthatin were investigated using kinase assay, migration assay, tube formation, Matrigel plug assay, western blot, immunofluorescence and human tumor xenograft model.

SjHSP70, a recombinant Schistosoma japonicum heat shock protein 70, is immunostimulatory and induces protective immunity against cercarial challenge in mice.

High levels of protective immunity can be induced in different animals immunized with radiation-attenuated (RA) Schistosoma cercariae or schistosomula. However, the schistosome-derived molecules responsible for the strong protective effect elicited by RA schistosome larvae have not been identified or characterized. The 70-kDa heat shock proteins of schistosomes are considered major immunogens, and may play an important role in stimulating high levels of innate and adaptive immune responses in an RA schistosome vaccine model.

Interactions Between Targeted Ultrasound Contrast Agents With Anti-Human Interleukin 8 Monoclonal Antibody and Activated Endothelial Cells.

The study aimed to explore the role of interleukin 8 (IL-8) in atherosclerotic plaques and develop a new method for the evaluation of endothelial function by assessing the interactions between the injured endothelial cells and the targeted ultrasound agent that carried anti-human IL-8 monoclonal antibody. Anti-human IL-8 monoclonal antibodies were associated to the shells of SonoVue microbubbles by covalent conjugation technology. The specific interaction between the microbubbles and the normal or injured endothelial cells was observed using an inverted microscope.

Assessment of fibrosis during the development of fatty liver in rabbits using real-time shear-wave elastography.

Nonalcoholic and alcoholic rabbit models of fatty liver were established by feeding on high-fat diet and alcohol, respectively, and fatty liver stiffness at different pathological stages was assessed with real-time shear-wave elastography (SWE), so as to investigate the fibrosis process during the development of fatty liver. The fatty liver stiffness of rabbit in nonalcoholic and alcoholic groups was higher than that in the control group, and that in alcohol group was higher than that in the nonalcoholic group (P<0.01).

Molecular characterization and identification of Th1 epitopes of a Schistosoma japonicum protein similar to prosaposin.

The tegument of schistosomula contains T cell antigens that might simulate the protective mechanisms of the radiation-attenuated vaccine in a mouse model of schistosomiasis. Immune mechanisms mediated by the CD4+ Th1 response are important in the RAV model. To rapidly identify Th1 epitopes in molecules from the Schistosoma japonicum schistosomula tegument, this study analyzed S.

[Preparation of the polypeptide antibody against human transcriptional factors TFDP1 and TFDP3].

Aim: To prepare the polyclonal antibody against human transcriptional factors DP3(TFDP3) and DP1(TFDP1) and identify their reactivity and specificity.

Methods: Two totally different peptides between TFDP1 and TFDP3 were chosen as antigens to inoculate rabbits. The proteins from HEK293 cells were transiently transfcted with eukaryotic expression vectors of TFDP1 and TFDP3.

Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F.

The two known DP proteins, TFDP1 and -2, bind E2Fs to form heterodimers essential for high affinity DNA binding and efficient transcriptional activation/repression. Here we report the identification of a new member of the DP family, human TFDP3. Despite the high degree of sequence similarity, TFDP3 is apparently distinct from TFDP1 in function.

BJ-HCC-20, a potential novel cancer-testis antigen.

In an effort to identify novel Cancer-Testis genes, we analyzed the sequence in the q26-28 region of human X chromosome by several on-line tools. The candidate sequences were then confirmed by experiments. We have obtained a novel Cancer-Testis gene, BJ-HCC-20.

[Expression and purification of recombinant N-terminal protein of SARS S1 subunit expressed in E. Coli].

Objective: To express and purify the recombinant N-terminal protein of SARS virus S1 subunit and to study its role in SARS immune response.

Methods: The gene encoding N-terminal 334 amino acid residuals of SARS virus S1 subunit was cloned and expressed in E. Coli.