Nuclear transport of phosphorylated LanCL2 promotes invadopodia formation and tumor progression of glioblastoma by activating STAT3/Cortactin signaling.

Introduction: Our previous study showed that the abscisic acid receptor lanthionine synthetase C-like 2 (LanCL2) is a significant prognostic factor for overall survival in young glioblastoma patients. However, the role of LanCL2 in glioblastoma remains unclear yet.

Objectives: This study aims to investigate the role of LanCL2 in regulating in-vitro cell invasion and in-vivo tumor progression of glioblastoma and its underlying mechanism.

Research Progress on the Etiology and Pathogenesis of Alzheimer's Disease from the Perspective of Chronic Stress.

Due to its extremely complex pathogenesis, no effective drugs to prevent, delay progression, or cure Alzheimer's disease (AD) exist at present. The main pathological features of AD are senile plaques composed of β-amyloid, neurofibrillary tangles formed by hyperphosphorylation of the tau protein, and degeneration or loss of neurons in the brain. Many risk factors associated with the onset of AD, including gene mutations, aging, traumatic brain injury, endocrine and cardiovascular diseases, education level, and obesity.

Proximity to Heavy Traffic Roads and Patient Characteristics of Late of Onset Asthma in an Urban Asthma Center.

Traffic-related pollution is associated with the onset of asthma and the development of different phenotypes of asthma. Few studies have investigated the association between traffic proximity and late-onset of asthma (LOA) and early-onset asthma (EOA). This study was conducted to investigate the associations of LOA phenotypes with a function of the distance between residence and heavy traffic roads (HTRs).

A COVID-19 case report from asymptomatic contact: implication for contact isolation and incubation management.

Background: As of 2 March, 2020, at least 80 151 coronavirus disease 2019 (COVID-19) cases were reported in China. Most of the patients had a history of visiting Hubei Province or contacting with people who had ever stayed in or passed by Hubei Province or were exposed to symptoms. Some patients got infected through only asymptomatic contact.

Excessive Iron Availability Caused by Disorders of Interleukin-10 and Interleukin-22 Contributes to High Altitude Polycythemia.

Because the pathogenesis of high altitude polycythemia (HAPC) is unclear, the aim of the present study was to explore whether abnormal iron metabolism is involved in the pathogenesis of HAPC and the possible cause. We examined the serum levels of iron, total iron binding capacity, soluble transferrin receptor (sTfR), ferritin, and hepcidin as well as erythropoietin (EPO) and inflammation-related cytokines in 20 healthy volunteers at sea level, 36 healthy high-altitude migrants, and 33 patients with HAPC. Mice that were exposed to a simulated hypoxic environment at an altitude of 5,000 m for 4 weeks received exogenous iron or intervention on cytokines, and the iron-related and hematological indices of peripheral blood and bone marrow were detected.

Fibroblasts play a potential role in bone destruction via osteopontin related caldesmon expression and polymerization in human non-functioning pituitary adenomas.

Non-functioning pituitary adenomas (NFPAs) are the most frequent pituitary tumors. The elucidation of the mechanisms of aggressive NFPAs in bone destruction is required in order to guide the clinical diagnosis and treatment of NFPAs. In the present study, we investigated the differential proteomics of fibroblasts isolated from clinical specimens of NFPAs with or without bone destruction.

The Association of SNAP25 Gene Polymorphisms in Attention Deficit/Hyperactivity Disorder: a Systematic Review and Meta-Analysis.

Attention deficit/hyperactivity disorder (ADHD) is one of the most highly heritable psychiatric disorders in childhood. The risk gene mutation accounts for about 60 to 90 % cases. Synaptosomal-associated protein of 25 kDa (SNAP-25) is a presynaptic plasma membrane protein which is expressed highly and specifically in the neuronal cells.

Aging as a Precipitating Factor in Chronic Restraint Stress-Induced Tau Aggregation Pathology, and the Protective Effects of Rosmarinic Acid.

Stress is an important risk factor of Alzheimer's disease (AD). It has been evidenced that stress could induce tau phosphorylation and increase tau insolubility in brain; however, little is known about the interactional effect of stress with aging on tauopathy. Therefore, we explored the effects of aging on stress-induced tauopathy and the potential mechanism in mouse model of chronic restraint stress (CRS).

[Effectiveness of acellular dermal matrix and parotid fascia in preventing Frey's syndrome: meta analysis].

Purpose: To evaluate and compare the effectiveness of acellular dermal matrix (ADM) and parotid fascia in preventing Frey's syndrome.

Methods: A literature research was performed using Wanfang Database, Chinese Biological Literature Database, China National Knowledge Infrastructure and Chinese Scientific Journals database of VIP from 2001 to 2013. Relative ratio (RR) was calculated and meta analysis was performed by Review Manager 5.

Ischemia preconditioning protects rat submandibular glands from ischemia/reperfusion injuries.

To investigate the effects of ischemia/reperfusion on rat submandibular glands without denervation and the possible protective effects of ischemia preconditioning on the glands that experienced ischemia/reperfusion, in-situ ischemia/reperfusion and ischemia preconditioning experimental models of submandibular glands of healthy male Wistar rats were conducted. For ischemia/reperfusion groups, the glands were subjected to 90 min of ischemia without denervation, followed by 1, 12, 24, or 72 h of reperfusion. Ischemia preconditioning was achieved by 3 min of ischemia following 3 min of reperfusion, performed three times before ischemia/reperfusion.

[Changes of neuroglobin in the pathologic process of contusion and laceration of brain in children].

Objective: To study the role of neuroglobin (Ngb) in the pathologic process of contusion and laceration of brain in children.

Methods: The proteins in the brain tissue were extracted by two-dimensional gel electrophoresis in 3 children undergoing brain ventricular neoplasms resection (normal brain tissue) and in 8 children with contusion and laceration of brain. The image analysis was done using the PDQuest 7.

Applied anatomy for pituitary adenoma resection.

Background: Pituitary adenomas are common intracranial tumors, with a rising incidence in China. Excision is a mainstay therapy for this disease, and is often carried out via transfrontal, transsphenoidal or transpterional approaches. However, few studies have systematically addressed the regional anatomy involved in these microsurgical procedures.

Vascular endothelial cells and pituitary hormone producing cells derived from embryonic stem cells therapy for hypopituitarism.

The common causes of hypopituitarism today are pituitary tumors, brain damage including traumatic brain injury, subarachnoid hemorrhage, neurosurgery, irradiation, and stroke. The main mechanism of hypopituitarism is vascular and neuronal damage of the hypothalamic-pituitary axis. At present, medical treatment of hypopituitarism caused by brain damage is hormone substitute with disadvantages of side effects, high expense and a requirement for daily injections over several years.

Removal of vestibular schwannoma and facial nerve preservation using small suboccipital retrosigmoid craniotomy.

Background: Vestibular schwannoma, the commonest form of intracranial schwannoma, arises from the Schwann cells investing the vestibular nerve. At present, the surgery for vestibular schwannoma remains one of the most complicated operations demanding for surgical skills in neurosurgery. And the trend of minimal invasion should also be the major influence on the management of patients with vestibular schwannomas.

[Surgical treatment of childhood craniopharyngioma: clinical analysis of 31 cases].

Objective: To study the diagnosis, surgical treatment and outcome of craniopharyngioma in 31 children.

Methods: The clinical data of 31 children (aged 7-14 years) with craniopharyngioma were studied retrospectively.

Results: Headache, visual disorder and growth retardation were main manifestations in the 31 children.

[Microsurgical treatment of tentorial meningiomas].

Objective: To discuss microsurgery in the treatment of tentorial meningiomas to reduce the operative mortality.

Methods: Clinical data of 32 patients were retrospectively analyzed. The operative approaches and outcomes and postoperative management of tentorial meningiomas were discussed.

[Multivariate analysis of impact of different neck treatment and prognostic factors affecting disease-free survival in patients with early-staged squamous cell carcinoma of tongue].

Objective: To analyze the prognostic factors affecting the disease-free survival in T1/T2N0M0-staged patients with squamous cell carcinoma of tongue and compare the effectiveness of different neck treatment modalities.

Methods: 97 consecutive patients with early-staged squamous cell carcinoma of tongue were included in this study. The treatment and following-up records were reviewed retrospectively.

Expression of galectin-3 correlates with apoptosis in pituitary adenoma cells.

Objective: To investigate the expressions of Galectin-3 (Gal-3), Bcl-2 and Bax in human pituitary adenomas, and to explore the interrelation among them.

Methods: RT-PCR and immunohistochemistry were applied to detect the mRNA and protein expressions of Gal-3, Bcl-2 and Bax in surgically excised human pituitary adenoma tissues, including invasive and non-invasive pituitary adenomas, and the correlation analysis was performed.

Results: The Gal-3 and Bcl-2 expressions in the invasive pituitary group were significantly higher than those in the non-invasive group, and the expression of Bax had no significant difference between the two groups.

[Thrombin preconditioning reduces brain injury caused by intracerebral infusion of high dose thrombin].

Objective: To explore the effect of the cerebral thrombin preconditioning on the thrombin-induced brain edema, to detect the expression of tumor necrosis factor-alpha (TNF-alpha), and to analyse the relationship between TNF-alpha and the thrombin-induced brain edema.

Methods: Forty SD rats were randomly divided into a ST group and a TT group. The rats received 50 L saline (ST group) or 1 U thrombin infusion (TT group), and received the second infusion (10 U thrombin) 24 h later.

[Microsurgical treatment of giant epidermoid cysts in the central region of the skull base].

Objective: To explore microsurgical treatment of giant epidermoid cysts in the central region of the skull base in 36 cases.

Methods: The clinic characteristics and the operation experience about the microsurgical treatment of giant epidermoid cysts in the central region of the skull base were retrospectively analyzed.

Results: In the 36 cases, 32 had total removal of the tumor, and the other 4 experienced subtotal removal.

[Preliminary study on transformation of the biological function of the cryopreserved osteoblasts cultured in vitro].

Objective: To culture and amplify the young rabbit's bone marrow stromal cells (BMSCs) in vitro, and to observe the effect of hypothermia on the cells' growing behavior and biological function.

Methods: BMSCs were acquired from the rabbit' tibia bone marrow and induced to mature osteoblasts in vitro. The cultured cells growing well in vitro were preserved in liquid nitrogen.

[Primary study of the method for repair of severe unilateral complete cleft lip].

Objective: To evaluate the probability of repairing the severe cleft lip and nose in one time.

Methods: 35 patients were included. A revised method was presented based on the popular methods used.

[Gamma knife treatment for pituitary prolactinomas].

Objective: To evaluate the outcome of gamma knife for prolactinomas.

Methods: Eighty-nine patients were treated by gamma knife and 51 were followed up. The dose to the tumor margin ranged from 18 Gy to 35 Gy (mean 26.