Publications by authors named "Yun-rui Zhang"
Epigenetic modifications in abdominal aortic aneurysms: from basic to clinical.
Front Cardiovasc Med
June 2024
Abdominal Aortic Aneurysm (AAA) is a disease characterized by localized dilation of the abdominal aorta, involving multiple factors in its occurrence and development, ultimately leading to vessel rupture and severe bleeding. AAA has a high mortality rate, and there is a lack of targeted therapeutic drugs. Epigenetic regulation plays a crucial role in AAA, and the treatment of AAA in the epigenetic field may involve a series of related genes and pathways.
View Article and Find Full Text PDFSpectroscopic methodologies and molecular docking studies on the interaction of antimalarial drug piperaquine and its metabolites with human serum albumin.
Spectrochim Acta A Mol Biomol Spectrosc
November 2019
Article Synopsis
- - Artemisinin-based combination therapy effectively treats uncomplicated Plasmodium falciparum malaria, with piperaquine (PQ) being a key partner drug; however, its interactions with human serum albumin (HSA) and its metabolites had not been previously studied.
- - The study used fluorescence, circular dichroism (CD) spectroscopy, and molecular docking to demonstrate that PQ and its metabolites bind to HSA, with binding mainly involving hydrogen bonds, van der Waals forces, and hydrophobic interactions, indicating varied affinities.
- - Additionally, binding of PQs to HSA caused structural changes in HSA, and further investigation into PQs' mechanism against malaria parasites suggested interactions with heme using H NMR spectroscopy
Ethnopharmacological Relevance: The chemical matrix of the herb Artemisia annua L. (A. annua), from which artemisinin (QHS) is isolated, can enhance both the bioavailability and efficacy of QHS.
View Article and Find Full Text PDFObjectives: The aim of this study was to systematically evaluate the relationship between urinary excretion of cadmium (U-Cd) and biomarkers of renal dysfunction.
Methods: One hundred eighty five non-smoking female farmers (aged from 44 to 71 years) were recruited from two rural areas with different cadmium levels of exposure in southern China. Morning spot urine samples were collected for detecting U-Cd, urinary creatinine (U-cre), β₂-microglobulin (β₂-MG), α₁-microglobulin (α₁-MG), metallothionein (MT), retinol binding protein (RBP), albumin (AB), N-acetyl-β-D-glucosaminidase (NAG), alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GGT) and kidney injury molecule-1 (KIM-1).