Publications by authors named "Yun-peng Cui"

Article Synopsis
  • Osteoarthritis (OA) is a leading cause of disability in older adults, and the study explores the role of PHF23, a new autophagy inhibitor, as a potential treatment target for OA.
  • The research involved manipulating PHF23 levels in chondrocyte cell strains while evaluating the effects of OA inducers and lysosome inhibitors using various analytical methods.
  • Key findings showed that knocking down PHF23 increased autophagy and mitophagy, reduced OA-associated proteins, and improved collagen expression, indicating that PHF23 could be a significant therapeutic focus for treating OA.
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Background: Researchers initially proposed the substitution of apoptotic chondrocytes in the superficial cartilage by injecting mesenchymal stem cells (MSCs) intraarticularly. This effect was termed as bio-resurfacing. Little evidence supporting the treatment of osteoarthritis (OA) by the delivery of a MSC suspension exists.

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Objective: To evaluate the effect of chondrocyte mitochondrial dysfunction on the development of cartilage degeneration.

Methods: In the study, 10 cartilage samples of the knee joint were collected during total knee arthroplasty surgery because of OA from April to October of 2012 in Peking University First Hospital. All the tissues were taken from transmission electron microscope (TEM) observation grouped by Outerbridge classification.

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