Publications by authors named "Yun-lv Sun"
Background: Feminization of animals derived from areas polluted by endocrine disrupting chemicals (EDCs) has been observed in all classes of vertebrates. However, feminization of artificially reared offspring by feeding of specific living organisms has never been reported.
Methods: Different food (including Limnodilus spp collected from the wild) and time treatment were applied to southern catfish.
Article Synopsis
- TALENs are a powerful genome editing tool that has proven effective for inducing mutations in Nile tilapia, achieving up to 81% efficiency at targeted genes related to sex differentiation.
- Six specific genes (dmrt1, foxl2, cyp19a1a, gsdf, igf3, and nrob1b) were targeted, demonstrating that mutations in dmrt1 and foxl2 significantly affect gonadal development and hormone levels, influencing sex differentiation.
- The study highlights the complex interplay between Foxl2 and Dmrt1 in regulating sex differentiation, suggesting they have opposing roles in tilapia by affecting cyp19a1a expression and estrogen production.
Fibroblast growth factors (FGFs) have been proved to participate in a wide variety of processes, including growth, differentiation, cell proliferation, migration, sex determination and sex differentiation. The roles of FGF9/16/20 subfamily members in the gonadal development of teleost fish have not yet been reported. Three FGFs (16, 20a and 20b) of the FGF9/16/20 subfamily were cloned from the Nile tilapia by RT-PCR and RACE.
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