Publications by authors named "Yun-liang Zheng"
Physalin B (PB) is one of the major constituents of Physalis alkekengi var. franchetii, a well-known Chinese traditional herb. In this study, we demonstrated for the first time that PB exhibits significant antiproliferative and apoptotic activity in A549 human lung cancer cells in a concentration-dependent and time-dependent manner.
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- A new ultra-pressure LC (UPLC) method was created to evaluate the quality of Radix Linderae, a traditional Chinese medicine, using chemical fingerprint analysis at two UV wavelengths (260 and 320 nm).
- *Eleven distinct peaks were identified in the chromatograms by comparing them to reference substances and existing literature data.
- *The study revealed significant variations in quality among Radix Linderae samples from different regions in China, indicating that maintaining consistent quality remains an important challenge.
Phytochemical investigation of the root tubers of Lindera aggregata resulted in the isolation of five new sesquiterpene lactones, linderagalactones A-E (1-5), along with eight known sesquiterpenoids, 3-eudesmene-1beta,11-diol, hydroxylindestenolide, strychnistenolide, hydroxyisogermafurenolide, atractylenolide III, linderane, neolinderalactone, and linderalactone. The structures and relative configurations of 1-5 were determined by spectroscopic methods, especially HRESIMS and 2D NMR techniques. The absolute configurations of 1-4 were defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra.
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