Publications by authors named "Yun-jie Dan"
Article Synopsis
- - The study investigates how the androgen receptor (AR) pathway may affect chronic hepatitis B (CHB) and acute liver failure (ALF) in males, focusing on the impact of a specific genetic variation (CAG repeat) in the AR gene.
- - Researchers analyzed 378 male CHB patients with ALF and 441 asymptomatic HBV carriers, finding that higher CAG repeat numbers significantly increased the risk of ALF and that testosterone levels varied during hepatitis flare and liver failure phases.
- - The results indicate that while serum testosterone levels were higher during hepatitis flare, they dropped sharply during ALF, and that men with the CAG variant had lower testosterone levels, linking genetic factors to susceptibility to HBV-related liver
The organic anion transporting polypeptide 1B1 (OATP1B1, encoded by SLCO1B1) plays an important role in the transport of endogenous and xenobiotic compounds, such as bile acids and rifampin. In this study, the association between OATP1B1 polymorphisms and rifampin hepatotoxicity was investigated using integrated population genetic analysis and functional studies. A total of 273 unrelated patients treated with rifampin were recruited.
View Article and Find Full Text PDFObjective: To investigate the dynamic correlation between pre-S1 antigen, pre-S2 antigen and HBV DNA in the serum of chronic hepatitis B (CHB) patients undergoing nucleoside analogue therapy.
Methods: 12 CHB patients with transient virological response after lamivudine treatment, and 20 patients treated with adefovir for 5 years were recruited in this study. Serum samples were collected at four time points when HBV DNA fluctuated sharply during lamivudine treatment, and at 0, 8, 12, 28, 52, 104, 156, 208, 260 weeks following adefovir treatment.