MicroRNA-375 functions as a tumor suppressor in osteosarcoma by targeting PIK3CA.

Osteosarcoma has become one of the most common primary malignant bone tumors in childhood and adult. Numerous studies have demonstrated that aberrant microRNA (miRNA) expression is involved in human disease including cancer. To date, the potential miRNAs regulating osteosarcoma growth and progression are not fully identified yet.

Meat consumption and risk of oral cavity and oropharynx cancer: a meta-analysis of observational studies.

Purpose: High meat consumption, especially red and processed meat consumption is associated with an increased risk of several cancers, however, evidence for oral cavity and oropharynx cancer is limited. Thus, we performed this meta-analysis to determine the association between intakes of total meat, processed meat, red meat, and white meat, and the risk of oral cavity and oropharynx cancer.

Methods: Electronic search of Pubmed, Embase, and Cochrane Library Central database was conducted to select relevant studies.

[Application of epiglottis with sternohyoid muscle in the surgery for laryngeal cancer].

Objective: To explore and evaluate the application of epiglottis with sternohyoid muscle in the surgery for laryngeal cancer.

Methods: Two fifty patients with laryngeal cancer were treated by partial laryngectomy and the laryngeal defects were reconstructed by epiglottic flap and sternohyoid muscle fascia flap. The staging of tumors: T2N0M0 23 cases, T3N1M0 14 cases, T3N2M0 13 cases.

[Effects of Xianling Gubao capsules for the treatment of bone loss induced by glucocorticoid].

Objective: To study the clinical effects of Xianling Gubao capsules for the treatment of glucocorticoid-induced osteoporosis.

Methods: From 2005.6 to 2007.

[Effects of yougui drink on the osteogenic differentiation of mesenchymal stem cells in the proximal femur in steroid-induced avascular necrosis of femoral head].

Objective: To investigate the effects of Yougui drink on osteogenic differentiation of bone mesenchymal stem cells (BMSCs) in the proximal femur in steroid-induced avascular necrosis of femoral head in vitro.

Methods: The BMSCs were induced to osteoblasts in vitro with a conditional medium. The cells cultured with Yougui drink serum were compared with the ordinary one, which both were examined by microscopy, MTU method, ALP and calcium node.