Publications by authors named "Yun-Zhi Fa"
Signature MicroRNA expression profile is associated with lipid metabolism in African green monkey.
Lipids Health Dis
February 2019
Background: Non-human primates (NHPs) are important models of medical research on obesity and cardiovascular diseases. As two of the most commonly used NHPs, cynomolgus macaque (CM) and African green monkey (AGM) own different capacities in lipid metabolism of which the mechanism is unknown. This study investigated the expression profiles of lipid metabolism-related microRNAs (miRNAs) in CM and AGM and their possible roles in controlling lipid metabolism-related gene expression.
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- Animal models, specifically rhesus macaques, are essential for understanding Zika virus (ZIKV) and developing treatments.
- The study found that after being infected, the macaques showed symptoms like fever and high levels of ZIKV RNA in various bodily fluids.
- The infection primarily targeted organs like the intestines, spleen, and glands, allowing researchers to investigate immune responses and disease progression in a relevant model.