Osmotic demyelination syndrome after correction of severe hyponatremia associated with pituitrin.

Osmotic demyelination syndrome (ODS) may be precipitated by aggressive correction of a hypoosmolar state. We report the case of a 24-year-old woman who developed ODS during rapid correction of asymptomatic hyponatremia caused by pituitrin prescribed for hemoptysis. After hyponatremia correction by NaCl supplementation, the patient developed limb weakness, blurred vision, hand and perioral numbness, and lisp.

Efficacy and safety of thrombolysis for stroke of unknown onset time: a meta-analysis.

Current stroke treatment guidelines exclude unknown onset stroke (UOS) patients from thrombolytic therapy even though several studies have reported significant treatment efficacy and safety. We performed a meta-analysis of relevant studies retrieved by systematic searches of the PubMed, Embase, and Cochrane databases up to December 31, 2013. Dichotomized modified Rankin Scale (mRS) scores 0-1 at 90 days, mRS 0-2 at 90 days, overall mortality, and symptomatic intracranial hemorrhage (sICH) incidence were collected as primary outcome measures.

Epidemiological and clinical characteristics of 266 cases of intracerebral hemorrhage in Hangzhou, China.

Ethnicity and socioeconomic factors can influence disease susceptibility, clinical presentation, and outcome. We investigated the clinical characteristics (age, sex, seasonal variation, lesion site, symptoms, complications, prognosis, and sequelae) and risk factors for intracerebral hemorrhage (ICH) in 266 cases treated at our hospital in Hangzhou City, China, from January 2011 to December 2011. Risk of ICH increased dramatically with age; only 4.

[Metabolism-based interaction of diphenytriazol and flavone compounds].

Objective: To observe the metabolism-based interaction of diphenytriazol and flavone compounds.

Methods: Flavone compounds kaempferol, isoharmnten and Elsholtzia blanda benth extract were chosen as the substrate of glucuronidation in the phase II metabolism. The metabolism was investigated in different rat liver microsome incubates pretreated with beta-naphthoflavone (BNF), diphenytriazol and tea oil (control).

[In vitro metabolic interaction between diphenytriazol and steroid hormone drugs].

Aim: To observe the metabolic interaction between diphenytriazol and steroid hormone drugs, and provide some useful information for clinical medication.

Methods: The steroid hormone drugs which may be co-administrated with diphenytriazol were selected, such as mifepriston, estradiol, medroxyprogesterone acetate, progesterone, norethisterone and so on. Diphenytriazol was incubated with each drug in rat liver microsome.

Induction of diphenytriazol on cytochrome CYP1A.

Aim: To study the effects of diphenytriazol on cytochrome P-450 (CYP) enzymes.

Methods: SD rats were pretreated with diphenytriazol. The catalytic activities of rat liver microsomes were determined by assaying ethoxyresorufin-O-deethylase (EROD) and pentoxyresorufin-O-dealkylase.

In vitro metabolism and inductive or inhibitive effect of DL111 on rat cytochrome P4501A enzyme.

In vitro metabolism and the inductive or inhibitive effect of DL111, a non-hormonal early pregnancy-terminating agent, toward cytochrome P450 (CYP) enzymes in rat liver microsomes were studied. In vitro metabolism of DL111 was performed in different rat liver microsomes (pretreated with phenobarbital (PB), dexamethasone (Dex), beta-naphthoflavone (BNF), DL111, respectively) and the catalytic abilities of these microsomes for DL111 were compared with control group. DL111 was well metabolized in microsomes pretreated with beta-naphthoflavone and itself.

[HPLC determination of zolmitriptan and its related substances].

Objective: To develop an analytical method and quality control for determination of zolmitriptan and related substances.

Methods: Zolmitriptan and related substances were separated and determined on a shimadzu CLC-C(8) column (150 mm x 6 mm, 10 microm) with a mobile phase of acetonitrile-10 mmol/L phosphate buffer (25:75 pH 7.5) and a flow-rate of 1 ml/min; the UV-VIS detector was operated at 229 nm.

[RP-HPLC determination of diphenytriazol in rat liver microsomal incubates and its application in in vitro metabolism].

Aim: To establish a RP-HPLC method for determination of diphenytriazol (DL111-IT) in rat hepatic microsomes.

Methods: DL111-IT in rat hepatic microsomal incubates was extracted with chloroform, using diazepam as internal standard. The determination was performed on a Lichrospher ODS-C18 reversed column (25 cm x 0.